Tafamidis

What is Tafamidis

Tafamidis, a selective transthyretin (TTR) stabilizer, is indicated for the treatment of the cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.

A significant reduction in all-cause mortality and cardiovascular-related hospitalization occurred with tafamidis therapy (20 mg once daily and 80 mg once daily) compared to placebo in a randomized, multicenter, international study that enrolled 441 patients with wild type or hereditary transthyretin-mediated amyloid cardiomyopathy (p = 0.0006).

Tafamidis was associated with a 30% relative reduction in the risk of death and a 32% decrease in risk of cardiovascular-related hospitalization compared to placebo. Incidence of adverse effects was similar between tafamidis and placebo.

Brand Names

• Vyndamax
• Vyndaqel

Indications

• transthyretin amyloid cardiomyopathy

For the treatment of wild type or hereditary transthyretin amyloid cardiomyopathy in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization

Side Effects

In a clinical trial involving 441 patients with transthyretin amyloid cardiomyopathy, the incidences of adverse reactions and adverse reaction-related study discontinuation were similar between patients that received tafamidis 20 mg once daily, tafamidis 80 mg (four 20 mg capsules), and placebo.

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• breast-feeding
• contraception requirements
• pregnancy

Interactions

• Abacavir; Dolutegravir; Lamivudine
• Alpelisib
• Bictegravir; Emtricitabine; Tenofovir Alafenamide
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Dolutegravir
• Dolutegravir; Lamivudine
• Dolutegravir; Rilpivirine
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir alafenamide
• Emtricitabine; Tenofovir disoproxil fumarate
• Glecaprevir; Pibrentasvir
• Glyburide
• Glyburide; Metformin
• Imatinib
• Irinotecan
• Irinotecan Liposomal
• Lamivudine; Tenofovir Disoproxil Fumarate
• Ledipasvir; Sofosbuvir
• Methotrexate
• Ombitasvir; Paritaprevir; Ritonavir
• Ozanimod
• Pazopanib
• Prazosin
• Rimegepant
• Rosuvastatin
• Sofosbuvir
• Sofosbuvir; Velpatasvir
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Sulfasalazine
• Talazoparib
• Tenofovir Alafenamide
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Topotecan
• Ubrogepant
• Vemurafenib