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What is Tadalafil
Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor similar to sildenafil and vardenafil.
It is administered orally for the treatment of pulmonary arterial hypertension (PAH), male erectile dysfunction (ED), benign prostatic hypertrophy (BPH), or the concurrent treatment of ED and BPH.
Tadalafil does not inhibit prostaglandins as do some agents for treating impotence (e.g., alprostadil).
Unlike sildenafil, visual disturbances have not been reported with tadalafil, which is more selective for PDE5 than for PDE6 present in the retina.
The duration of action of tadalafil for the treatment of ED (up to 36 hours) appears to be longer than that of sildenafil and vardenafil. Because PDE inhibitors promote erection only in the presence of sexual stimulation, the longer duration of action of tadalafil allows for more spontaneity in sexual activity.
Indications
- altitude sickness prophylaxis
- benign prostatic hyperplasia (BPH)
- erectile dysfunction (ED)
- pulmonary hypertension
- sexual dysfunction
Monitoring Parameters
- blood pressure
Contraindications
- angina
- breast-feeding
- cardiac arrhythmias
- coronary artery disease
- dialysis
- gastroesophageal reflux disease (GERD)
- heart failure
- hematological disease
- hepatic disease
- hiatal hernia
- hypertension
- hypotension
- leukemia
- multiple myeloma
- myocardial infarction
- nitrate/nitrite therapy
- non-arteritic anterior ischemic optic neuropathy
- penile structural abnormality
- peptic ulcer disease
- polycythemia
- pregnancy
- priapism
- prostate cancer
- renal failure
- renal impairment
- retinitis pigmentosa
- sexually transmitted disease
- sickle cell disease
- stroke
- veno-occlusive disease (VOD)
- visual disturbance
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Guaifenesin; Phenylephrine
- Alfuzosin
- Alpha-blockers
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Amyl Nitrite
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Boceprevir
- Bosentan
- Brompheniramine; Carbetapentane; Phenylephrine
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Phenylephrine
- Cariprazine
- Ceritinib
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Phenylephrine
- Clarithromycin
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Crizotinib
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Quinidine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Doxazosin
- Dronedarone
- Duloxetine
- Dutasteride; Tamsulosin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethanol
- Etravirine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Guaifenesin; Phenylephrine
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrocodone; Phenylephrine
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketoconazole
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Lopinavir; Ritonavir
- Lorcaserin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Mifepristone
- Mitotane
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nifedipine
- Nilotinib
- Nitrates
- Nitroglycerin
- Nitroprusside
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Pazopanib
- Phenobarbital
- Phenoxybenzamine
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Posaconazole
- Prazosin
- Primidone
- Quinidine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Riociguat
- Ritonavir
- Sapropterin
- Saquinavir
- Silodosin
- Simeprevir
- St. John’s Wort, Hypericum perforatum
- Tamsulosin
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Terazosin
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Vardenafil
- Vemurafenib
- Verapamil
- Vigabatrin
- Voriconazole
- Zafirlukast
- Zileuton
