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What is Succimer
Succimer is an oral chelating agent used to treat lead toxicity. Succimer works by forming water-soluble chelates with lead, which are excreted in the urine.
Succimer may have efficacy for lead encephalopathy and for other heavy metal poisoning such as mercury or arsenic poisoning; data are limited. Succimer was approved by the FDA in January 1991.
Brand Name
Chemet
Indications
- lead toxicity
Side Effects
- abdominal pain
- angioedema
- anorexia
- arrhythmia exacerbation
- back pain
- chills
- cough
- diarrhea
- dizziness
- drowsiness
- dysuria
- elevated hepatic enzymes
- eosinophilia
- fatigue
- fever
- flank pain
- headache
- hemorrhoids
- hypercholesterolemia
- infection
- irritability
- lacrimation
- maculopapular rash
- metallic taste
- nasal congestion
- nausea
- neutropenia
- oral ulceration
- paresthesias
- peripheral neuropathy
- proteinuria
- pruritus
- rash
- rhinorrhea
- throat irritation
- thrombocytosis
- urinary retention
- urticaria
- vesicular rash
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- platelet count
- serum creatinine/BUN
Contraindications
- breast-feeding
- dehydration
- dialysis
- hepatic disease
- hypovolemia
- infants
- neonates
- neutropenia
- pregnancy
- renal failure
- renal impairment
Interactions
- Dimercaprol
- Edetate Calcium Disodium, Calcium EDTA
- Edetate Disodium, Disodium EDTA
