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What is Sparfloxacin
Description
NOTE: This drug is discontinued in the US.
Description: Sparfloxacin is an oral fluoroquinolone antibiotic approved for the treatment of community-acquired pneumonia and acute bacterial exacerbations of chronic bronchitis.
Sparfloxacin is less active than ciprofloxacin against Pseudomonas aeruginosa and some other gram-negative bacilli. Sparfloxacin has a longer half-life than ciprofloxacin and can be administered once daily. Unlike ciprofloxacin, sparfloxacin does not interact significantly with theophylline.
Phototoxicity is more common with sparfloxacin and lomefloxacin than with other fluoroquinolones. QT prolongation may also occur with use of sparfloxacin; therefore, its use is contraindicated in patients receiving other drugs that can prolong the QTc interval.
Sparfloxacin was granted final FDA approval for community-acquired pneumonia and chronic bronchitis on December 19, 1996.
Brand Name
Zagam
Indications & Dosage
- Acinetobacter anitratus
- Acinetobacter lwoffii
- bronchitis
- Chlamydia trachomatis
- Chlamydophila pneumoniae
- Citrobacter diversus
- community-acquired pneumonia
- Enterobacter cloacae
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Legionella pneumophila
- Moraxella catarrhalis
- Morganella morganii
- Mycobacterium leprae
- Mycobacterium tuberculosis
- Mycoplasma pneumoniae
- Neisseria gonorrhoeae
- Proteus mirabilis
- Proteus vulgaris
- Staphylococcus aureus (MSSA)
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Viridans streptococci
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anemia
- angioedema
- anxiety
- aplastic anemia
- asthenia
- azotemia
- bronchospasm
- confusion
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- fever
- flatulence
- hallucinations
- headache
- hemolytic anemia
- hepatic failure
- hepatitis
- increased intracranial pressure
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- maculopapular rash
- nausea
- nightmares
- pancytopenia
- paranoia
- photosensitivity
- pneumonitis
- pruritus
- pseudomembranous colitis
- QT prolongation
- restlessness
- seizures
- Stevens-Johnson syndrome
- suicidal ideation
- tendon rupture
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- urticaria
- vomiting
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- atrial fibrillation
- bradycardia
- breast-feeding
- cardiac disease
- cerebrovascular disease
- children
- colitis
- corticosteroid therapy
- diarrhea
- geriatric
- GI disease
- heart failure
- hypokalemia
- inflammatory bowel disease
- myasthenia gravis
- organ transplant
- pregnancy
- pseudomembranous colitis
- QT prolongation
- quinolone hypersensitivity
- renal impairment
- seizure disorder
- sunlight (UV) exposure
- tendinitis
- tendinopathy
- tendon pain
- tendon rupture
- ulcerative colitis
- viral infection
Interactions
- Abarelix
- Acetohexamide
- Alfuzosin
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apomorphine
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Bepridil
- Canagliflozin; Metformin
- Chloroprocaine
- Chlorpromazine
- Chlorpropamide
- Cisapride
- Clarithromycin
- Class IA Antiarrhythmics
- Clomipramine
- Clozapine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desipramine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Didanosine, ddI
- Disopyramide
- Dolasetron
- Doxepin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Flecainide
- Fluoxetine; Olanzapine
- Fluphenazine
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Granisetron
- Halofantrine
- Haloperidol
- Halothane
- Imipramine
- Incretin Mimetics
- Insulins
- Isoflurane
- Levomethadyl
- Linagliptin
- Linagliptin; Metformin
- Maprotiline
- Mefloquine
- Meperidine; Promethazine
- Mesoridazine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Nortriptyline
- Octreotide
- Olanzapine
- Ondansetron
- Paliperidone
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Pimozide
- Posaconazole
- Pramlintide
- Procainamide
- Procaine
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Ranolazine
- Saquinavir
- Saxagliptin
- Sevoflurane
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sulfonylureas
- Tacrolimus
- Telithromycin
- Terfenadine
- Tetrabenazine
- Tetracaine
- Thiazolidinediones
- Thiethylperazine
- Thioridazine
- Tolazamide
- Tolbutamide
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Vardenafil
- Vorinostat
- Ziprasidone
