Sodium Stibogluconate

What is Sodium Stibogluconate

Sodium stibogluconate is a parenteral heavy metal pentavalent antimony (Sb5+ or Sbv) indicated for the treatment of leishmaniasis.

Indications & Dosage

  • Leishmania aethiopica
  • Leishmania braziliensis
  • Leishmania guyanensis
  • Leishmania infantum
  • Leishmania major
  • Leishmania panamensis
  • Leishmania peruviana
  • Leishmania tropica
  • leishmaniasis
  • leishmaniasis prophylaxis

This drug may also have activity against the following microorganismsLeishmania aethiopicaLeishmania braziliensisLeishmania guyanensisLeishmania infantumLeishmania majorLeishmania panamensisLeishmania peruvianaLeishmania tropica

Side Effects

Transient cough immediately after injection has been reported with sodium stibogluconate during clinical trials. In the unlikely event of infusion-related reactions, including coughing, vomiting, or substernal pain, discontinue administration immediately, and take care if sodium stibogluconate is readministered intravenously.

Intravenous injection of sodium stibogluconate may also cause an injection site reaction, specifically transient pain along the course of the vein and eventually thrombosis of that vein. Filter sodium stibogluconate immediately before use and administer intravenously very slowly to reduce the risk of local thrombosis.

Monitoring Parameters

  • ECG


  • alcoholism
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • coronary artery disease
  • diabetes mellitus
  • females
  • geriatric
  • heart failure
  • hepatic disease
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • long QT syndrome
  • malnutrition
  • myocardial infarction
  • pregnancy
  • QT prolongation
  • renal failure
  • renal impairment
  • thyroid disease
  • ventricular arrhythmias


No information is available regarding drug interactions associated with Sodium Stibogluconate


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