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What is Siltuximab
Siltuximab is an interleukin-6 antagonist indicated for the treatment of adult patients with multicentric Castleman disease who are human immunodeficiency virus-negative and human herpesvirus-8-negative.
Monitor patients for signs and symptoms of infection; do not start siltuximab in patients with a severe active infection.
Severe infusion-related reactions may occur; therefore, administer siltuximab in a setting that provides resuscitation equipment, medication, and personnel trained to provide resuscitation.
Brand Name
Sylvant
Indications & Dosage
- coronavirus disease 2019 (COVID-19)
- multicentric Castleman disease
- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
INVESTIGATIONAL USE: For adjunctive use in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection†, the virus that causes coronavirus disease 2019 (COVID-19)
Side Effects
- abdominal pain
- anaphylactoid reactions
- antibody formation
- back pain
- chest pain (unspecified)
- constipation
- cytokine release syndrome
- diarrhea
- dizziness
- edema
- edema
- erythema
- flushing
- gastroesophageal reflux
- GI perforation
- headache
- hypercholesterolemia
- hypertension
- hypertriglyceridemia
- hyperuricemia
- hyperuricemia
- hypotension
- hypotension
- infection
- infection
- infusion-related reactions
- infusion-related reactions
- maculopapular rash
- maculopapular rash
- nausea
- nephrotoxicity
- neutropenia
- oral ulceration
- palpitations
- pharyngitis
- pruritus
- psoriasis
- rash
- rash
- skin hyperpigmentation
- thrombocytopenia
- thrombocytopenia
- vomiting
- weight gain
- weight gain
- xerosis
Monitoring Parameters
- CBC with differential
Contraindications
- breast-feeding
- contraception requirements
- diverticulitis
- GI perforation
- infants
- infection
- infusion-related reactions
- neonates
- neutropenia
- peptic ulcer disease
- pregnancy
- reproductive risk
- thrombocytopenia
- vaccination
Interactions
- Alfentanil
- Amlodipine; Atorvastatin
- Apixaban
- Atorvastatin
- Atorvastatin; Ezetimibe
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Caffeine; Ergotamine
- Canakinumab
- Carbamazepine
- Cisapride
- Clozapine
- Cyclosporine
- Dextromethorphan; Quinidine
- Dienogest; Estradiol valerate
- Dihydroergotamine
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Ergotamine
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Everolimus
- Ezetimibe; Simvastatin
- Fentanyl
- Fosphenytoin
- Leuprolide; Norethindrone
- Levonorgestrel
- Live Vaccines
- Lovastatin
- Lovastatin; Niacin
- Mestranol; Norethindrone
- Niacin; Simvastatin
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Phenytoin
- Pimozide
- Quinidine
- Rivaroxaban
- Segesterone Acetate; Ethinyl Estradiol
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Tacrolimus
- Theophylline, Aminophylline
- Thioridazine
- Tizanidine
- Warfarin
