Should ACE inhibitors be used prophylactically in patients with SSc to prevent SRC?
There is no data to support prophylactic ACE inhibitor therapy in patients with Systemic Sclerosis. In addition, some data suggests that patients on an ACE inhibitor at the time of diagnosis of SRC may have a worse prognosis. Routine use of ACE inhibitors may prevent early identification of SRC in some patients by modulating hypertension as an early sign of SRC. These patients may present in renal failure without an elevated blood pressure, losing the potential warning sign of impending SRC.
