Selegiline

What is Selegiline

Selegiline is classified as a selective monoamine oxidase (MAO) type-B inhibitor.

Selegiline is available orally for the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa, and transdermally for the treatment of major depressive disorder. 

Brand Name

• Carbex
• Eldepryl
• EMSAM
• Zelapar

Indications

• depression
• Parkinson’s disease
• parkinsonism

Side Effects

1. abdominal pain
2. agitation
3. akinesia
4. alopecia
5. amblyopia
6. amnesia
7. anemia
8. angina
9. anorexia
10. anxiety
11. aphasia
12. arthralgia
13. arthropathy
14. ataxia
15. atopic dermatitis
16. atrial fibrillation
17. atrial flutter
18. AV block
19. back pain
20. blepharospasm
21. blurred vision
22. bone pain
23. bradycardia
24. bronchospasm
25. cardiac arrest
26. cardiomyopathy
27. cataracts
28. chest pain (unspecified)
29. chills
30. cholecystitis
31. cholelithiasis
32. colitis
33. confusion
34. conjunctivitis
35. constipation
36. contact dermatitis
37. cyanosis
38. cystitis
39. dehydration
40. depression
41. diabetes mellitus
42. diaphoresis
43. diarrhea
44. diplopia
45. dizziness
46. drowsiness
47. dysgeusia
48. dyskinesia
49. dyspepsia
50. dysphagia
51. dyspnea
52. dystonic reaction
53. ecchymosis
54. edema
55. ejaculation dysfunction
56. elevated hepatic enzymes
57. emotional lability
58. encephalopathy
59. eosinophilia
60. epididymitis
61. epistaxis
62. erythema
63. esophageal ulceration
64. esophagitis
65. fatigue
66. fever
67. flank pain
68. flatulence
69. fluid retention
70. gastritis
71. GI bleeding
72. GI obstruction
73. gingivitis
74. glossitis
75. gout
76. hallucinations
77. headache
78. hearing loss
79. heart failure
80. hematoma
81. hepatitis
82. hiccups
83. hypercholesterolemia
84. hyperglycemia
85. hyperhidrosis
86. hyperkalemia
87. hyperkinesis
88. hyperlipidemia
89. hyperphosphatemia
90. hypersalivation
91. hypertension
92. hypertensive crisis
93. hypertonia
94. hypoesthesia
95. hypoglycemia
96. hypokalemia
97. hyponatremia
98. hyporeflexia
99. hypotension
100. hypotonia
101. hypovitaminosis
102. impotence (erectile dysfunction)
103. impulse control symptoms
104. increased urinary frequency
105. infection
106. insomnia
107. involuntary movements
108. irritability
109. lethargy
110. leukocytosis
111. libido decrease
112. malaise
113. mania
114. memory impairment
115. migraine
116. muscle cramps
117. myalgia
118. myocardial infarction
119. myoclonia
120. nausea
121. nephrolithiasis
122. neuropathic pain
123. new primary malignancy
124. nightmares
125. nocturia
126. ocular hemorrhage
127. oral ulceration
128. orgasm dysfunction
129. orthostatic hypotension
130. pallor
131. palpitations
132. paranoia
133. paresthesias
134. peptic ulcer
135. peripheral edema
136. peripheral vasodilation
137. pharyngitis
138. photosensitivity
139. pleural effusion
140. pneumothorax
141. prostatic hypertrophy
142. proteinuria
143. pruritus
144. psychosis
145. pulmonary edema
146. pyrosis (heartburn)
147. rash
148. restlessness
149. retinal detachment
150. rhinitis
151. seborrhea
152. seizures
153. serotonin syndrome
154. sinus tachycardia
155. sinusitis
156. skin discoloration
157. skin irritation
158. skin ulcer
159. stomatitis
160. subdural hematoma
161. suicidal ideation
162. supraventricular tachycardia (SVT)
163. syncope
164. tardive dyskinesia
165. teeth grinding (bruxism)
166. tinnitus
167. tremor
168. urinary incontinence
169. urinary retention
170. urinary urgency
171. vertigo
172. visual impairment
173. vomiting
174. weakness
175. weight loss
176. xerophthalmia
177. xerosis
178. xerostomia

Monitoring Parameters

• blood pressure
• heart rate
• LFTs
• serum creatinine/BUN
• thyroid function tests (TFTs)

Contraindications

• abrupt discontinuation
• alcoholism
• ambient temperature increase
• behavioral changes
• bipolar disorder
• breast-feeding
• children
• driving or operating machinery
• ethanol ingestion
• geriatric
• heating pad
• hepatic disease
• hypertension
• hypertensive crisis
• hypotension
• impulse control symptoms
• mania
• MAOI therapy
• melanoma
• orthostatic hypotension
• phenylketonuria
• pheochromocytoma
• pregnancy
• psychosis
• renal failure
• renal impairment
• schizophrenia
• suicidal ideation
• sunlight (UV) exposure

Interactions

• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Almotriptan
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Alprazolam
• Altretamine
• Ambrisentan
• Amide local anesthetics
• Amifampridine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Anagrelide
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anxiolytics; Sedatives; and Hypnotics
• Apalutamide
• Apraclonidine
• Aprepitant, Fosaprepitant
• Armodafinil
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• atypical antipsychotic
• Azilsartan
• Azilsartan; Chlorthalidone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzonatate
• Beta-adrenergic blockers
• Beta-agonists
• Betaxolol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Boceprevir
• Bretylium
• Brimonidine
• Brimonidine; Brinzolamide
• Brimonidine; Timolol
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carteolol
• Carvedilol
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Clevidipine
• Clomipramine
• Clonazepam
• Clonidine
• Clorazepate
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Cyclobenzaprine
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Desflurane
• Desipramine
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Diazoxide
• Dienogest; Estradiol valerate
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Diphenhydramine; Hydrocodone; Phenylephrine
• Dolasetron
• Dorzolamide; Timolol
• Doxazosin
• Doxepin
• Dronabinol
• Dronedarone
• Droperidol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Elbasvir; Grazoprevir
• Eletriptan
• Elvitegravir
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Enzalutamide
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esketamine
• Eslicarbazepine
• Esmolol
• Estazolam
• Ester local anesthetics
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Ethacrynic Acid
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Etomidate
• Felbamate
• Felodipine
• Fenoldopam
• Fentanyl
• Fluphenazine
• Flurazepam
• food
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Frovatriptan
• Furosemide
• Gabapentin
• Gallium Ga 68 Dotatate
• General anesthetics
• Ginseng, Panax ginseng
• Glipizide; Metformin
• Glyburide; Metformin
• Granisetron
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanabenz
• Guanfacine
• Halothane
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
• Iloprost
• Imipramine
• Incretin Mimetics
• Indapamide
• Insulins
• Iobenguane I 131
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Irbesartan
• Isavuconazonium
• Isoflurane
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Isradipine
• Ketamine
• Labetalol
• Lamotrigine
• Lasmiditan
• Lemborexant
• Levetiracetam
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levodopa
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Lisinopril
• Lithium
• Loop diuretics
• Lopinavir; Ritonavir
• Lorazepam
• Lorcaserin
• Losartan
• Loxapine
• Lumacaftor; Ivacaftor
• Lumacaftor; Ivacaftor
• Magnesium Salts
• Mannitol
• Maprotiline
• Mecamylamine
• Meglitinides
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Mesoridazine
• Mestranol; Norethindrone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methazolamide
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Metoclopramide
• Metolazone
• Metoprolol
• Midazolam
• Milnacipran
• Minoxidil
• Mirabegron
• Mirtazapine
• Mitotane
• Modafinil
• Moexipril
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nalbuphine
• Naproxen; Sumatriptan
• Naratriptan
• Nateglinide
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Netupitant, Fosnetupitant; Palonosetron
• Nicardipine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Nortriptyline
• Olmesartan
• Ombitasvir; Paritaprevir; Ritonavir
• Ondansetron
• Oritavancin
• Oxazepam
• Oxcarbazepine
• Oxycodone
• Oxymetazoline
• Oxymorphone
• Ozanimod
• Palonosetron
• Pazopanib
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phenoxybenzamine
• Phentolamine
• Phenylephrine; Promethazine
• Pindolol
• Posaconazole
• Potassium-sparing diuretics
• Pramlintide
• Prazosin
• Pregabalin
• Primidone
• Procaine
• Procarbazine
• Prochlorperazine
• Promethazine
• Propofol
• Propoxyphene
• Propranolol
• Protriptyline
• Quazepam
• Quinapril
• Ramelteon
• Ramipril
• Rasagiline
• Remifentanil
• Repaglinide
• Reserpine
• Ritonavir
• Rizatriptan
• Sacubitril; Valsartan
• Safinamide
• Saxagliptin
• Secobarbital
• Sedating H1-blockers
• Segesterone Acetate; Ethinyl Estradiol
• Selective norepinephrine reuptake inhibitors
• Selective serotonin reuptake inhibitors
• Serotonin norepinephrine reuptake inhibitors
• Sevoflurane
• Sibutramine
• Sildenafil
• Simvastatin; Sitagliptin
• Sitagliptin
• Sodium Oxybate
• Solriamfetol
• Sotalol
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Succinimides
• Sufentanil
• Sulfonylureas
• Sumatriptan
• Sympathomimetics
• Tapentadol
• Tedizolid
• Telaprevir
• Telmisartan
• Telotristat Ethyl
• Temazepam
• Terazosin
• Teriflunomide
• Tetrabenazine
• Tetracaine
• Tetrahydrozoline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiotepa
• Thiothixene
• Tiagabine
• Timolol
• Torsemide
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Trazodone
• Treprostinil
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trimipramine
• Valbenazine
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Valsartan
• Vasodilators
• Venlafaxine
• Verapamil
• Vilazodone
• Vortioxetine
• Yohimbine
• Zolmitriptan
• Zonisamide