Sacituzumab Govitecan

What is Sacituzumab Govitecan

Sacituzumab govitecan is an antibody-drug conjugate composed of a humanized monoclonal antibody (sacituzumab) which binds to the trophoblast cell-surface antigen-2 (Trop-2) covalently linked to SN-38, a topoisomerase I inhibitor.

It is approved for the treatment of patients with metastatic triple-negative breast cancer who have received at least 2 prior therapies for metastatic disease.

Brand Name

TRODELVY

Indications

  • breast cancer

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. acneiform rash
  4. alopecia
  5. anemia
  6. anemia
  7. anorexia
  8. anorexia
  9. antibody formation
  10. arthralgia
  11. asthenia
  12. back pain
  13. bone marrow suppression
  14. colitis
  15. constipation
  16. constipation
  17. cough
  18. dehydration
  19. dehydration
  20. diarrhea
  21. diarrhea
  22. dizziness
  23. dysgeusia
  24. dyspnea
  25. dyspnea
  26. edema
  27. elevated hepatic enzymes
  28. elevated hepatic enzymes
  29. esophagitis
  30. exfoliative dermatitis
  31. fatigue
  32. fatigue
  33. fever
  34. headache
  35. headache
  36. hyperglycemia
  37. hyperglycemia
  38. hypermagnesemia
  39. hypoalbuminemia
  40. hypoalbuminemia
  41. hypocalcemia
  42. hypoesthesia
  43. hypoglycemia
  44. hypokalemia
  45. hypokalemia
  46. hypomagnesemia
  47. hypomagnesemia
  48. hyponatremia
  49. hypophosphatemia
  50. hypophosphatemia
  51. infection
  52. infection
  53. influenza
  54. infusion-related reactions
  55. insomnia
  56. leukopenia
  57. maculopapular rash
  58. nausea
  59. nausea
  60. neutropenia
  61. neutropenia
  62. paresthesias
  63. peripheral edema
  64. peripheral neuropathy
  65. pleural effusion
  66. prolonged bleeding time
  67. prolonged bleeding time
  68. pruritus
  69. rash
  70. rash
  71. stomatitis
  72. thrombocytopenia
  73. thrombocytopenia
  74. vomiting
  75. vomiting
  76. weakness
  77. xerosis

Monitoring Parameters

  • CBC with differential
  • LFTs
  • pregnancy testing

Contraindications

  • bone marrow suppression
  • breast-feeding
  • chemotherapy-induced nausea/vomiting
  • contraception requirements
  • diarrhea
  • infertility
  • infusion-related reactions
  • male-mediated teratogenicity
  • neutropenia
  • poor metabolizers
  • pregnancy
  • pregnancy testing
  • reproductive risk

Interactions

  • Atazanavir
  • Atazanavir; Cobicistat
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Etravirine
  • Gemfibrozil
  • Glecaprevir; Pibrentasvir
  • Indinavir
  • Lopinavir; Ritonavir
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ritonavir