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What is Ruxolitinib
Ruxolitinib is a kinase inhibitor that inhibits Janus Associated Kinases (JAKs), JAK1 and JAK2.
It is indicated for the treatment of adults with intermediate- or high-risk myelofibrosis (e.g., primary myelofibrosis, post-polycythemia vera myelofibrosis, and post-essential thrombocythemia myelofibrosis), adults with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea, and patients 12 years and older with steroid-refractory acute graft-versus-host disease.
Hematologic toxicity and infection have been reported with ruxolitinib therapy.
Brand Name
Jakafi
Indications
- coronavirus disease 2019 (COVID-19)
- graft-versus-host disease (GVHD)
- myelofibrosis
- polycythemia vera
- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
INVESTIGATIONAL USE: For adjunctive use in the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the virus that causes coronavirus disease 2019 (COVID-19)
Side Effects
- abdominal pain
- abdominal pain
- anemia
- anemia
- arthralgia
- asthenia
- bleeding
- constipation
- cough
- cystitis
- diarrhea
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- dizziness
- dyspnea
- dyspnea
- ecchymosis
- ecchymosis
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- fatigue
- fatigue
- fever
- flatulence
- headache
- headache
- hematoma
- hematoma
- hypercholesterolemia
- hypercholesterolemia
- hypertension
- hypertension
- hypertriglyceridemia
- hypertriglyceridemia
- hypotension
- infection
- infection
- leukoencephalopathy
- nausea
- neutropenia
- neutropenia
- new primary malignancy
- peripheral edema
- petechiae
- pharyngitis
- pruritus
- pruritus
- purpura
- pyuria
- pyuria
- rash
- respiratory depression
- thrombocytopenia
- thrombocytopenia
- thrombosis
- vertigo
- vertigo
- weight gain
- weight gain
Monitoring Parameters
- CBC with differential
- LFTs
- platelet count
- serum creatinine/BUN
- serum lipid profile
- serum triglycerides
- skin cancer screening exam
Contraindications
- abrupt discontinuation
- anemia
- bleeding
- breast-feeding
- fungal infection
- hepatic disease
- hepatitis
- hypercholesterolemia
- hypertriglyceridemia
- infection
- mycobacterial infection
- neutropenia
- new primary malignancy
- pregnancy
- progressive multifocal leukoencephalopathy
- renal disease
- renal impairment
- skin cancer
- thrombocytopenia
- tuberculosis
- viral infection
Interactions
- Aldesleukin, IL-2
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apalutamide
- Aprepitant, Fosaprepitant
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Cimetidine
- Clarithromycin
- Clozapine
- Cobicistat
- Conivaptan
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etravirine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Letermovir
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Ritonavir
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- St. John’s Wort, Hypericum perforatum
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Upadacitinib
- Verapamil
- Voriconazole
- Zafirlukast
