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What is Rucaparib
Rucaparib is an oral poly (ADP-ribose) polymerase (PARP) inhibitor.
It is indicated as monotherapy for the treatment of patients with BRCA-mutated ovarian cancer after 2 or more prior chemotherapy regimens, and for the maintenance treatment of recurrent ovarian cancer.
It is also indicated for the treatment of BRCA-mutated metastatic castration-resistant prostate cancer, in patients previously treated with androgen receptor-directed therapy and taxane-based chemotherapy.
PARP enzymes are involved in normal cellular homeostasis, including DNA transcription, cell cycle regulation, and DNA repair; increased cytotoxicity and anti-tumor activity has been noted in cell lines and mouse tumor models with deficiencies in BRCA.
The most common grade 3 or 4 adverse reactions occurring in more than 10% of patients included anemia, asthenia/fatigue, increased ALT, and neutropenia.
Brand Name
Rubraca
Indications
- ovarian cancer
- prostate cancer
Side Effects
- abdominal pain
- anemia
- anorexia
- asthenia
- bleeding
- constipation
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- exfoliative dermatitis
- fatigue
- fever
- flushing
- headache
- hypercholesterolemia
- hypertriglyceridemia
- hyponatremia
- hypophosphatemia
- infection
- leukopenia
- lymphopenia
- maculopapular rash
- nausea
- neutropenia
- new primary malignancy
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pharyngitis
- photosensitivity
- pruritus
- psoriasis
- rash
- renal failure (unspecified)
- stomatitis
- thrombocytopenia
- thromboembolism
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- CBC with differential
- pregnancy testing
Contraindications
- breast-feeding
- contraception requirements
- leukemia
- male-mediated teratogenicity
- myelodysplastic syndrome (MDS)
- pregnancy
- pregnancy testing
- reproductive risk
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Tramadol
- Alfentanil
- Alosetron
- Amlodipine; Celecoxib
- Anagrelide
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendamustine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine; Lidocaine
- Caffeine
- Caffeine; Ergotamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Carvedilol
- Celecoxib
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Citalopram
- Clomipramine
- Clopidogrel
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Cyclosporine
- Diazepam
- Diclofenac
- Diclofenac; Misoprostol
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dofetilide
- Doxorubicin
- Dronabinol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Enalapril; Felodipine
- Ergotamine
- Ethosuximide
- Fedratinib
- Felodipine
- Fentanyl
- Flibanserin
- Fluvastatin
- Fosphenytoin
- Glyburide
- Glyburide; Metformin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Oxycodone
- Indinavir
- Isradipine
- Ixabepilone
- Lemborexant
- Lidocaine
- Lidocaine; Prilocaine
- Lomitapide
- Melatonin
- Meloxicam
- Methadone
- Mexiletine
- Midazolam
- Nateglinide
- Nelfinavir
- Nimodipine
- Nisoldipine
- Ospemifene
- Oxycodone
- Phenobarbital
- Phenytoin
- Pimozide
- Pirfenidone
- Porfimer
- Primidone
- Propafenone
- Propranolol
- Quinine
- Ramelteon
- Rasagiline
- Riluzole
- Roflumilast
- Ropinirole
- Sirolimus
- Sufentanil
- Tacrolimus
- Theophylline, Aminophylline
- Tinidazole
- Tizanidine
- Tolbutamide
- Torsemide
- Tramadol
- Triazolam
- Ubrogepant
- Verteporfin
- Vinorelbine
- Voriconazole
- Warfarin
- Zolpidem
