Romiplostim

What is Romiplostim

Romiplostim is an injectable thrombopoietin receptor agonist produced by recombinant DNA technology in Escherichia coli. 

It is used for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to corticosteroids, immunoglobins, or splenectomy; it may also be used in children and adolescents with ITP for at least 6 months who have insufficient response to these treatments. 

Brand Name

Nplate

Indications

• immune thrombocytopenic purpura (ITP)

For the treatment of chronic immune thrombocytopenic purpura (ITP) in patients who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy

Side Effects

1. abdominal pain
2. angioedema
3. antibody formation
4. arthralgia
5. cough
6. diarrhea
7. dizziness
8. dyspepsia
9. fever
10. headache
11. headache
12. headache
13. infection
14. insomnia
15. myalgia
16. nausea
17. new primary malignancy
18. paresthesias
19. peripheral edema
20. purpura
21. rash
22. sinusitis
23. thrombocytopenia
24. thrombocytosis
25. thromboembolism
26. thrombosis
27. urticaria
28. vomiting

Monitoring Parameters

• CBC
• platelet count

Contraindications

• bleeding
• breast-feeding
• hepatic disease
• myelodysplastic syndrome (MDS)
• pregnancy
• thromboembolic disease

Interactions

There are no drug interactions associated with Romiplostim products.