Rh0 Immune Globulin

What is Rh0 Immune Globulin

Rh₀ [D] immune globulin is a parenteral immune globulin used to prevent isoimmunization in Rh₀ [D]-negative women exposed to Rh₀ [D]-positive blood and thus, prevent the risk of erythroblastosis fetalis in current or subsequent pregnancies.

Rh₀ [D] immune globulin is a solution containing IgG antibodies against erythrocyte antigen Rh₀ [D]. 

Indications & Dosage

• erythroblastosis fetalis prophylaxis
• immune thrombocytopenic purpura (ITP)
• Rh isoimmunization prophylaxis

For Rh isoimmunization prophylaxis in Rh₀ [D]-negative patient and to ensure subsequent erythroblastosis fetalis prophylaxis in females with present and future pregnancies

Side Effects

1. abdominal pain
2. acute respiratory distress syndrome (ARDS)
3. anaphylactic shock
4. anaphylactoid reactions
5. anemia
6. anuria
7. arthralgia
8. asthenia
9. back pain
10. cardiac arrest
11. chest pain (unspecified)
12. chills
13. diaphoresis
14. diarrhea
15. disseminated intravascular coagulation (DIC)
16. dizziness
17. drowsiness
18. dyspnea
19. ecchymosis
20. edema
21. erythema
22. fever
23. headache
24. heart failure
25. hematuria
26. hemolysis
27. hemolytic-uremic syndrome
28. hyperbilirubinemia
29. hyperhidrosis
30. hyperkinesis
31. hypertension
32. hypotension
33. hypoxia
34. infection
35. injection site reaction
36. jaundice
37. muscle cramps
38. myalgia
39. myocardial infarction
40. nausea
41. oliguria
42. pallor
43. peripheral vasodilation
44. prolonged bleeding time
45. pruritus
46. pulmonary edema
47. rash
48. renal failure (unspecified)
49. sinus tachycardia
50. urticaria
51. vomiting
52. weakness
53. weight gain
54. wheezing

Monitoring Parameters

• hemoglobin/hematocrit
• platelet count
• red blood cell count (RBC)
• reticulocyte count
• Rh serology
• urinalysis

Contraindications

• agammaglobulinemia
• anemia
• anticoagulant therapy
• breast-feeding
• children
• coagulopathy
• diabetes mellitus
• geriatric
• hemolysis
• hemolytic anemia
• hemophilia
• hepatitis
• hypogammaglobulinemia
• IgA deficiency
• infants
• infection
• intramuscular administration
• intravenous administration
• leukemia
• lymphoma
• neonates
• pregnancy
• renal impairment
• requires a specialized care setting
• systemic lupus erythematosus (SLE)
• thrombocytopenia
• vitamin K deficiency

Interactions

• Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
• Measles/Mumps/Rubella Vaccines, MMR
• Rotavirus Vaccine
• Rubella Virus Vaccine Live
• Tetanus Toxoid
• Varicella-Zoster Virus Vaccine, Live