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What is Repaglinide
Repaglinide is a meglitinide oral hypoglycemic agent given before meals and is used as an adjunct to diet and exercise in the treatment of type 2 diabetes mellitus (DM) in adults.
Brand Name
Prandin
Indications
- type 2 diabetes mellitus
For the treatment of type 2 diabetes mellitus uncontrolled by diet and exercise alone
Side Effects
- alopecia
- anaphylactoid reactions
- angina
- arrhythmia exacerbation
- arthralgia
- back pain
- chest pain (unspecified)
- confusion
- constipation
- diarrhea
- dyspepsia
- elevated hepatic enzymes
- headache
- heart failure
- hemolytic anemia
- hepatitis
- hypertension
- hypoglycemia
- infection
- jaundice
- leukopenia
- myocardial infarction
- nausea
- pallor
- palpitations
- pancreatitis
- paresthesias
- peripheral edema
- rhinitis
- secondary failure
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- thrombocytopenia
- tremor
- vomiting
- weight gain
Monitoring Parameters
- blood glucose
- glycosylated hemoglobin A1c (HbA1c)
Contraindications
- breast-feeding
- children
- diabetic ketoacidosis
- fever
- geriatric
- hepatic disease
- hypoglycemia
- infants
- infection
- pregnancy
- surgery
- trauma
- type 1 diabetes mellitus
Interactions
- Abiraterone
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alogliptin; Metformin
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Androgens
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apalutamide
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bexarotene
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Butabarbital
- Canagliflozin; Metformin
- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carteolol
- Carvedilol
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chloroquine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chromium
- Cimetidine
- Cisapride
- Clarithromycin
- Clofarabine
- Clonidine
- Clopidogrel
- Cobicistat
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticosteroids
- Crizotinib
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Danazol
- Dapagliflozin; Metformin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Diazoxide
- Dienogest; Estradiol valerate
- Diethylpropion
- Diethylstilbestrol, DES
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enzalutamide
- Ephedrine
- Epinephrine
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esmolol
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estramustine
- Estrogens
- Estropipate
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etonogestrel
- Exenatide
- Ezetimibe; Simvastatin
- Fedratinib
- Fenofibrate
- Fenofibric Acid
- Fexofenadine; Pseudoephedrine
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluoxymesterone
- Fluphenazine
- Fosphenytoin
- Garlic, Allium sativum
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Hydantoins
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxychloroquine
- Hydroxyprogesterone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Indapamide
- Insulin Glargine; Lixisenatide
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Itraconazole
- Ivosidenib
- Ketoconazole
- Labetalol
- Lanreotide
- Ledipasvir; Sofosbuvir
- Leflunomide
- Letermovir
- Leuprolide; Norethindrone
- Levobetaxolol
- Levobunolol
- Levonorgestrel
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Lisdexamfetamine
- Lithium
- Lixisenatide
- Lomefloxacin
- Loop diuretics
- Loratadine; Pseudoephedrine
- Lorcaserin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Mecasermin rinfabate
- Mecasermin, Recombinant, rh-IGF-1
- Medroxyprogesterone
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine; Levonordefrin
- Mesoridazine
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methazolamide
- Methohexital
- Methylphenidate
- Methyltestosterone
- Metoprolol
- Metreleptin
- Metyrapone
- Midodrine
- Mifepristone
- Mitotane
- Monoamine oxidase inhibitors
- Nadolol
- Nandrolone Decanoate
- Naproxen; Pseudoephedrine
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicardipine
- Nicotine
- Norepinephrine
- Norethindrone
- Norgestrel
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Orlistat
- Oxandrolone
- Oxymetholone
- Pasireotide
- Pazopanib
- Pegvisomant
- Pemoline
- Penbutolol
- Pentamidine
- Pentobarbital
- Pentoxifylline
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenobarbital
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Pindolol
- Posaconazole
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prilocaine; Epinephrine
- Primidone
- Prochlorperazine
- Progesterone
- Progestins
- Promethazine
- Propoxyphene
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Pyrimethamine; Sulfadoxine
- Quinine
- Quinolones
- Racepinephrine
- Ranolazine
- Regular Insulin; Isophane Insulin (NPH)
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritodrine
- Salicylates
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Somatropin, rh-GH
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Sympathomimetics
- Tacrolimus
- Tegaserod
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Teriflunomide
- Testolactone
- Testosterone
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Thyroid hormones
- Timolol
- tobacco
- Tolvaptan
- Trandolapril; Verapamil
- Trifluoperazine
- Trimethoprim
- Tucatinib
- Vemurafenib
- Verapamil
- Voriconazole
- Zafirlukast
