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What is Rapacuronium
NOTE: This drug is discontinued in the US.
Rapacuronium is a short-acting, nondepolarizing, neuromuscular blocking agent.
It was originally approved for use as an adjunct to general anesthesia, for endotracheal intubation, and for neuromuscular blockade during short surgical procedures.
Brand Name
Raplon
Indications & Dosage
- endotracheal intubation
- neuromuscular blockade
Side Effects
- anaphylactoid reactions
- angioedema
- apnea
- atrial fibrillation
- bradycardia
- bronchospasm
- dyspnea
- erythema
- flushing
- hypertension
- hypotension
- increased intracranial pressure
- malignant hyperthermia
- muscle paralysis
- nausea
- pruritus
- rash
- respiratory depression
- sinus tachycardia
- urticaria
- ventricular fibrillation
- ventricular tachycardia
- vomiting
Monitoring Parameters
- arterial blood gases (ABGs)
- peripheral nerve stimulation
- serum electrolytes
- serum magnesium
Contraindications
- acid/base imbalance
- asthma
- breast-feeding
- bromide hypersensitivity
- burns
- cardiac disease
- cerebral palsy
- children
- chronic obstructive pulmonary disease (COPD)
- corticosteroid therapy
- dehydration
- electrolyte imbalance
- geriatric
- head trauma
- hepatic disease
- hypermagnesemia
- hypocalcemia
- hypokalemia
- hyponatremia
- increased intracranial pressure
- infants
- lung cancer
- malignant hyperthermia
- metabolic alkalosis
- myasthenia gravis
- myopathy
- neonates
- neuromuscular blocking agent hypersensitivity
- neuromuscular disease
- obesity
- pregnancy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- respiratory acidosis
- respiratory depression
- surgery
- trauma
Interactions
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Amide local anesthetics
- Aminoglycosides
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Apomorphine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Bacitracin
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzonatate
- Beta-blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Botulinum Toxins
- Brimonidine; Timolol
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium-channel blockers
- Calcium; Vitamin D
- Capreomycin
- Carbamazepine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carteolol
- Carvedilol
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chromium
- Clevidipine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colistimethate, Colistin, Polymyxin E
- Corticosteroids
- Cyclosporine
- Demeclocycline
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dorzolamide; Timolol
- Doxycycline
- Enalapril; Felodipine
- Esmolol
- Ester local anesthetics
- Felodipine
- Fentanyl
- Fosphenytoin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Hetastarch; Dextrose; Electrolytes
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Indapamide
- Isradipine
- Labetalol
- Levobetaxolol
- Levobunolol
- Levomethadyl
- Levorphanol
- Lincosamides
- Lithium
- Loop diuretics
- Magnesium
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Methadone
- Methohexital
- Metoprolol
- Minocycline
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nalbuphine
- Nebivolol
- Nebivolol; Valsartan
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Omadacycline
- Oxycodone
- Oxymorphone
- Penbutolol
- Perindopril; Amlodipine
- Phenylephrine; Promethazine
- Phenytoin
- Pindolol
- Polymyxin B
- Polymyxins
- Procainamide
- Promethazine
- Propoxyphene
- Propranolol
- Quinidine
- Quinine
- Remifentanil
- Sarecycline
- Sedating H1-blockers
- Skeletal Muscle Relaxants
- Sotalol
- Sufentanil
- Tapentadol
- Tetracycline
- Tetracyclines
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiopental
- Timolol
- Trandolapril; Verapamil
- Vancomycin
- Verapamil
