Quinapril

What is Quinapril

Quinapril is an oral angiotensin-converting enzyme (ACE) inhibitor used in the treatment of hypertension and heart failure.

Similar to ramipril, quinapril is a prodrug that requires deesterification to the active metabolite quinaprilat. Quinaprilat is threefold more potent than the parent compound.

Quinapril may be dosed once or twice daily when used for hypertension, and is given twice daily for the treatment of heart failure. Quinapril does not contain a sulfhydryl group, which has implications regarding the drug’s adverse reaction profile.

Quinapril has been investigated in patients with angina, and found to have neutral effects.

During a 27 month study in 1,750 patients with ischemic heart disease and preserved left ventricular function, quinapril was well-tolerated, but had no benefit in reducing the occurrence of ischemic events or progression of coronary atherosclerosis.

Quinapril was initially approved by the FDA in November 1991.

Brand Name

Accupril

Indications

• heart failure
• hypertension

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. amblyopia
5. anaphylactoid reactions
6. angina
7. angioedema
8. anxiety
9. arthralgia
10. azotemia
11. back pain
12. chest pain (unspecified)
13. cholestasis
14. constipation
15. cough
16. depression
17. diaphoresis
18. diarrhea
19. dizziness
20. drowsiness
21. dyspepsia
22. dyspnea
23. edema
24. elevated hepatic enzymes
25. exfoliative dermatitis
26. fatigue
27. flatulence
28. flushing
29. GI bleeding
30. headache
31. heart failure
32. hemolytic anemia
33. hepatic failure
34. hepatic necrosis
35. hepatitis
36. hyperkalemia
37. hypertensive crisis
38. hyponatremia
39. hypotension
40. impotence (erectile dysfunction)
41. infection
42. insomnia
43. jaundice
44. malaise
45. myalgia
46. myocardial infarction
47. nausea
48. neutropenia
49. oliguria
50. orthostatic hypotension
51. palpitations
52. pancreatitis
53. paresthesias
54. pemphigus
55. pharyngitis
56. photosensitivity
57. pneumonitis
58. pruritus
59. rash
60. renal failure (unspecified)
61. sinus tachycardia
62. stroke
63. syncope
64. teratogenesis
65. thrombocytopenia
66. vertigo
67. vomiting
68. xerostomia

Monitoring Parameters

• blood pressure
• serum creatinine/BUN
• serum potassium
• serum sodium

Contraindications

• ACE-inhibitor induced angioedema
• angioedema
• Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
• aortic stenosis
• autoimmune disease
• Black patients
• bone marrow suppression
• breast-feeding
• cardiomyopathy
• cerebrovascular disease
• children
• collagen-vascular disease
• coronary artery disease
• dialysis
• geriatric
• heart failure
• hepatic disease
• hereditary angioedema
• hymenoptera venom (insect sting) allergy desensitization
• hyperkalemia
• hyponatremia
• hypotension
• hypovolemia
• immunosuppression
• low-density lipoprotein apheresis
• pregnancy
• renal artery stenosis
• renal disease
• renal failure
• renal impairment
• scleroderma
• systemic lupus erythematosus (SLE)

Interactions

• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Pseudoephedrine
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alemtuzumab
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alogliptin; Metformin
• Alpha-glucosidase Inhibitors
• Alprostadil
• Amifostine
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amphetamine; Dextroamphetamine Salts
• Amyl Nitrite
• Angiotensin II
• Angiotensin II receptor antagonists
• Apomorphine
• Apraclonidine
• Aprotinin
• Aripiprazole
• Asenapine
• Azathioprine
• Azilsartan
• Azilsartan; Chlorthalidone
• Baclofen
• Benzphetamine
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bosentan
• Brexpiprazole
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Cabergoline
• Calcium Phosphate, Supersaturated
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carvedilol
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloroprocaine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Ciprofloxacin
• Clozapine
• Co-Enzyme Q10, Ubiquinone
• Cocaine
• Codeine; Phenylephrine; Promethazine
• Conivaptan
• Cyclophosphamide
• Cyclosporine
• Dapagliflozin; Metformin
• Delafloxacin
• Demeclocycline
• Desloratadine; Pseudoephedrine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Quinidine
• Diazoxide
• Diethylpropion
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Doxycycline
• Drospirenone
• Drospirenone; Estradiol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enflurane
• Entecavir
• Ephedrine
• Eplerenone
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ertugliflozin; Metformin
• Estradiol
• Estradiol Cypionate; Medroxyprogesterone
• Etomidate
• Everolimus
• Fexofenadine; Pseudoephedrine
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Fluorescein
• Fluoxetine; Olanzapine
• Fospropofol
• Gemifloxacin
• General anesthetics
• Glipizide; Metformin
• Glyburide; Metformin
• Gold
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Pseudoephedrine
• Haloperidol
• Halothane
• Heparin
• Hydralazine; Isosorbide Dinitrate, ISDN
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Ibuprofen; Pseudoephedrine
• Icatibant
• Iloperidone
• Iloprost
• Incretin Mimetics
• Indapamide
• Insulins
• Intravenous Lipid Emulsions
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Irbesartan
• Iron Dextran
• Isocarboxazid
• Isoflurane
• Isoproterenol
• Isosorbide Dinitrate, ISDN
• Isosorbide Mononitrate
• Isosulfan Blue
• Kanamycin
• Ketamine
• Lanthanum Carbonate
• Levodopa
• Levofloxacin
• Linagliptin; Metformin
• Lisdexamfetamine
• Lithium
• Loop diuretics
• Loratadine; Pseudoephedrine
• Losartan
• Lovastatin; Niacin
• Lurasidone
• Magnesium Salts
• Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
• Meglitinides
• Mestranol; Norethindrone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methamphetamine
• Methohexital
• Methylphenidate
• Milrinone
• Minocycline
• Moxifloxacin
• Naproxen; Pseudoephedrine
• Nateglinide
• Nebivolol; Valsartan
• Nefazodone
• Nesiritide, BNP
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nitrates
• Nitroglycerin
• Nitroprusside
• Non-Ionic Contrast Media
• Nonsteroidal antiinflammatory drugs
• Norfloxacin
• Ofloxacin
• Olanzapine
• Olmesartan
• Omadacycline
• Oxymetazoline
• Paliperidone
• Pentoxifylline
• Phenelzine
• Phenylephrine
• Phenylephrine; Promethazine
• Polyethylene Glycol; Electrolytes
• Polyethylene Glycol; Electrolytes; Ascorbic Acid
• Potassium
• Pramlintide
• Prazosin
• Pregabalin
• Procainamide
• Procaine
• Propofol
• Pseudoephedrine
• Quinidine
• Rasagiline
• Repaglinide
• Risperidone
• Sacubitril; Valsartan
• Salicylates
• Sarecycline
• Selegiline
• Sevoflurane
• SGLT2 Inhibitors
• Silodosin
• Sirolimus
• Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Spironolactone
• Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
• Sulfonylureas
• Tacrolimus
• Telavancin
• Telbivudine
• Telmisartan
• Temsirolimus
• Tetrabenazine
• Tetracaine
• Tetracycline
• Tetracyclines
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thiothixene
• Tizanidine
• Tolvaptan
• Tranylcypromine
• Trazodone
• Triamterene
• Trimethoprim
• Valsartan
• Yohimbine
• Ziprasidone