Protein C Concentrate Human

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Protein C Concentrate Human Brand Name– Ceprotin

What is Protein C Concentrate Human

Protein C Concentrate Human (Ceprotin), is a plasma-derived concentrate of protein C and is the first product approved for the prevention and treatment of venous thrombosis and purpura fulminans in adult and pediatric patients with severe, congenital protein C deficiency.

Protein C is a natural anticoagulant that when deficient leaves patients hypercoagulable and at risk for thrombotic events, including deep vein thrombosis and pulmonary embolism.

In patients with severe deficiency, more severe thrombotic events, such as purpura fulminans, are possible.

Patients with severe protein C deficiency who are undergoing acute thrombotic episodes can also be administered fresh frozen plasma to replace endogenous protein C.

However, large volumes of plasma are typically needed, which can lead to fluid overload.

Indications

  1. deep venous thrombosis (DVT)
  2. deep venous thrombosis (DVT) prophylaxis
  3. pulmonary embolism
  4. pulmonary embolism prophylaxis
  5. purpura fulminans
  6. thrombosis prophylaxis

For thrombosis prophylaxis and treatment, including treatment of deep venous thrombosis (DVT) and pulmonary embolism (PE), deep venous thrombosis (DVT) prophylaxis, and pulmonary embolism prophylaxis, in patients with severe congenital protein C deficiency

Side Effects

  1. bleeding
  2. dizziness
  3. hyperhidrosis
  4. injection site reaction
  5. pruritus
  6. rash
  7. restlessness

Monitoring Parameters

  • protein C concentrations

Contraindications

  • breast-feeding
  • heart failure
  • heparin hypersensitivity
  • heparin-induced thrombocytopenia (HIT)
  • hypertension
  • murine protein hypersensitivity
  • pregnancy
  • renal impairment
  • viral infection

Interactions

  • Alteplase
  • Factor X
  • Prothrombin Complex Concentrate, Human
  • Warfarin

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