C1 Inhibitor Human

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C1 Inhibitor Human Brand Names

Berinert | Cinryze | HAEGARDA

What is C1 Inhibitor Human

C1 inhibitor human is plasma-derived concentrate of C1 esterase inhibitor indicated for the prevention of angioedema attacks in adolescents and adults with hereditary angioedema (HAE) and for the treatment of acute abdominal, facial, or laryngeal attacks of HAE in children, adolescents, and adults.

Hereditary angioedema is a rare genetic disorder that presents as acute, recurrent attacks of soft tissue skin swelling, abdominal pain, and potentially life-threatening upper airway obstruction.

Patients with HAE have low concentrations of endogenous or functional C1 inhibitor, which is a plasma protein that maintains the natural regulation of the contact, complement, and fibrinolytic systems.

Of importance, C1 inhibitor therapy will likely not be effective for patients with autoantibody-mediated acquired C1 inhibitor deficiency and high titer monoclonal anti-C1 inhibitor antibody concentrations.

Indications

  • angioedema prophylaxis
  • hereditary angioedema

For routine angioedema prophylaxis in patients with hereditary angioedema

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. antibody formation
  4. chills
  5. dizziness
  6. dysgeusia
  7. erythema
  8. fever
  9. headache
  10. infection
  11. influenza
  12. injection site reaction
  13. myocardial infarction
  14. nausea
  15. pharyngitis
  16. pruritus
  17. pulmonary embolism
  18. rash
  19. stroke
  20. thrombosis
  21. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • central venous catheter placement
  • obesity
  • pregnancy
  • thromboembolic disease
  • viral infection

Interactions

There are no drug interactions associated with C1 Inhibitor Human products.

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