Prothrombin Complex Concentrate Human

Prothrombin Complex Concentrate Human Brand Name– Kcentra

What is Prothrombin Complex Concentrate Human

Prothrombin complex concentrate Human (PCC) is prepared from human plasma and contains factors II, VII, IX and X, and antithrombotic proteins C and S.

The potency of PCC is defined by content of factor IX. PCC is FDA-approved for urgent reversal of vitamin K antagonist (VKA) therapy in patients with acute major bleeding or need for urgent surgery or invasive procedure.

According to the CHEST guidelines, PCC is preferred over fresh frozen plasma for the rapid reversal of anticoagulation in patients with VKA-associated major bleeding.

Both fatal and non-fatal arterial and venous thromboembolic events have been reported with PCC in clinical trials and during post marketing surveillance. PCC may not be suitable for patients with a thromboembolic event in the previous 3 months.

Kcentra was FDA approved in April 2013.


  • coagulation factor replacement

For coagulation factor replacement in patients with acquired coagulation factor deficiency due to vitamin K antagonist therapy with acute major bleeding or need for urgent surgery or invasive procedure

Side Effects

  1. anemia
  2. angioedema
  3. anxiety
  4. atrial fibrillation
  5. bronchospasm
  6. disseminated intravascular coagulation (DIC)
  7. dyspnea
  8. flushing
  9. headache
  10. heart failure
  11. hypokalemia
  12. hypotension
  13. hypoxia
  14. infection
  15. insomnia
  16. myocardial infarction
  17. nausea
  18. pleural effusion
  19. pulmonary edema
  20. pulmonary embolism
  21. sinus tachycardia
  22. stroke
  23. tachypnea
  24. thromboembolism
  25. thrombosis
  26. urticaria
  27. vomiting
  28. wheezing

Monitoring Parameters

  • INR


  • albumin hypersensitivity
  • angina
  • breast-feeding
  • disseminated intravascular coagulation (DIC)
  • heparin hypersensitivity
  • heparin-induced thrombocytopenia (HIT)
  • hepatitis
  • infection
  • labor
  • myocardial infarction
  • obstetric delivery
  • peripheral vascular disease
  • plasma protein hypersensitivity
  • pregnancy
  • stroke
  • thromboembolic disease
  • thromboembolism

Prothrombin complex concentrate is contraindicated in patients with known anaphylactic or severe systemic reactions to prothrombin complex concentrate, heparin hypersensitivityplasma protein hypersensitivity (i.e., proteins C and S, antithrombin III), hypersensitivity to coagulation factors II, VII, IX, and X, and human albumin hypersensitivity.


  • Alteplase
  • Aminocaproic Acid
  • Apixaban
  • Betrixaban
  • Edoxaban
  • Factor VIIa, Recombinant
  • Fondaparinux
  • Protein C Concentrate, Human
  • Rivaroxaban
  • Tranexamic Acid
  • Warfarin

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