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Prothrombin Complex Concentrate Human Brand Name– Kcentra
What is Prothrombin Complex Concentrate Human
Prothrombin complex concentrate Human (PCC) is prepared from human plasma and contains factors II, VII, IX and X, and antithrombotic proteins C and S.
The potency of PCC is defined by content of factor IX. PCC is FDA-approved for urgent reversal of vitamin K antagonist (VKA) therapy in patients with acute major bleeding or need for urgent surgery or invasive procedure.
According to the CHEST guidelines, PCC is preferred over fresh frozen plasma for the rapid reversal of anticoagulation in patients with VKA-associated major bleeding.
Both fatal and non-fatal arterial and venous thromboembolic events have been reported with PCC in clinical trials and during post marketing surveillance. PCC may not be suitable for patients with a thromboembolic event in the previous 3 months.
Kcentra was FDA approved in April 2013.
Indications
- coagulation factor replacement
For coagulation factor replacement in patients with acquired coagulation factor deficiency due to vitamin K antagonist therapy with acute major bleeding or need for urgent surgery or invasive procedure
Side Effects
- anemia
- angioedema
- anxiety
- atrial fibrillation
- bronchospasm
- disseminated intravascular coagulation (DIC)
- dyspnea
- flushing
- headache
- heart failure
- hypokalemia
- hypotension
- hypoxia
- infection
- insomnia
- myocardial infarction
- nausea
- pleural effusion
- pulmonary edema
- pulmonary embolism
- sinus tachycardia
- stroke
- tachypnea
- thromboembolism
- thrombosis
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- INR
Contraindications
- albumin hypersensitivity
- angina
- breast-feeding
- disseminated intravascular coagulation (DIC)
- heparin hypersensitivity
- heparin-induced thrombocytopenia (HIT)
- hepatitis
- infection
- labor
- myocardial infarction
- obstetric delivery
- peripheral vascular disease
- plasma protein hypersensitivity
- pregnancy
- stroke
- thromboembolic disease
- thromboembolism
Prothrombin complex concentrate is contraindicated in patients with known anaphylactic or severe systemic reactions to prothrombin complex concentrate, heparin hypersensitivity, plasma protein hypersensitivity (i.e., proteins C and S, antithrombin III), hypersensitivity to coagulation factors II, VII, IX, and X, and human albumin hypersensitivity.
Interactions
- Alteplase
- Aminocaproic Acid
- Apixaban
- Betrixaban
- Edoxaban
- Factor VIIa, Recombinant
- Fondaparinux
- Protein C Concentrate, Human
- Rivaroxaban
- Tranexamic Acid
- Warfarin
