Pexidartinib Brand Name– Turalio
What is Pexidartinib
Pexidartinib is a colony-stimulating factor-1 receptor inhibitor used for the treatment of adult patients with symptomatic tenosynovial giant cell tumor associated with severe morbidity or functional limitations and not amenable to improvement with surgery.
Due to the risk of hepatotoxicity, all prescribers, pharmacies, and patients must be certified or enrolled in the TURALIO REMS program to prescribe, dispense, or receive pexidartinib.
Routine liver function monitoring is required. Information about the drug and the program can be found at www.turalioREMS.com or by calling 1-833-887-2546
Indications
- tenosynovial giant cell tumor
For the treatment of tenosynovial giant cell tumor
NOTE: The FDA has designated pexidartinib as an orphan drug for the treatment of giant cell tumor of the tendon sheath.
Side Effects
- acneiform rash
- alopecia
- amnesia
- anemia
- anorexia
- asthenia
- blepharedema
- blurred vision
- cholangitis
- cholestasis
- confusion
- constipation
- contact dermatitis
- diplopia
- dysgeusia
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- fatigue
- fever
- hair discoloration
- hepatotoxicity
- hyperactivity
- hyperbilirubinemia
- hyperbilirubinemia
- hypercholesterolemia
- hypercholesterolemia
- hypertension
- hypertension
- hypoesthesia
- hypophosphatemia
- hypophosphatemia
- lymphopenia
- lymphopenia
- maculopapular rash
- malaise
- memory impairment
- neutropenia
- neutropenia
- oral ulceration
- papilledema
- paresthesias
- peripheral edema
- peripheral neuropathy
- photophobia
- pruritus
- rash
- rash
- skin hyperpigmentation
- skin hypopigmentation
- stomatitis
- thrombocytopenia
- urticaria
- visual impairment
- vomiting
- vomiting
- xerostomia
Monitoring Parameters
- LFTs
- pregnancy testing
- serum creatinine/BUN
Contraindications
- breast-feeding
- contraception requirements
- hepatic disease
- hepatotoxicity
- infertility
- male-mediated teratogenicity
- pregnancy
- pregnancy testing
- renal impairment
- reproductive risk
Interactions
- Abemaciclib
- Alfentanil
- Allopurinol
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amlodipine; Atorvastatin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Auranofin
- Avanafil
- Avapritinib
- Azathioprine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Buspirone
- Busulfan
- Calcium Carbonate; Magnesium Hydroxide
- Cannabidiol
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Chlorpromazine
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Cobimetinib
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Danazol
- Dantrolene
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dextromethorphan; Quinidine
- Diclofenac
- Diclofenac; Misoprostol
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Diphenhydramine; Ibuprofen
- Disulfiram
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Entrectinib
- Enzalutamide
- Erlotinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole
- Esomeprazole; Naproxen
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Ezetimibe; Simvastatin
- Famotidine
- Famotidine; Ibuprofen
- Fentanyl
- Floxuridine
- Fluconazole
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Gemfibrozil
- Glecaprevir; Pibrentasvir
- grapefruit juice
- H2-blockers
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Indinavir
- Infliximab
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Interferon Beta-1a
- Interferon Beta-1b
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lansoprazole
- Lansoprazole; Naproxen
- Lesinurad; Allopurinol
- Letermovir
- Leuprolide; Norethindrone
- Levonorgestrel
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Magnesium Hydroxide
- Mercaptopurine, 6-MP
- Mestranol; Norethindrone
- Methotrexate
- Methyldopa
- Mifepristone
- Minocycline
- Mitotane
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nilotinib
- Nisoldipine
- Nitrofurantoin
- Nizatidine
- Non-oral combination contraceptives
- Norethindrone
- Norgestrel
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oral Contraceptives
- Pantoprazole
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Peginterferon beta-1a
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Probenecid
- Propylthiouracil, PTU
- Pyrazinamide, PZA
- Quinidine
- Rabeprazole
- Ranitidine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Riluzole
- Ritonavir
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Sildenafil
- Simvastatin
- Simvastatin; Sitagliptin
- Sirolimus
- Sorafenib
- St. John’s Wort, Hypericum perforatum
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulindac
- Tacrolimus
- Telithromycin
- Testosterone
- Thioguanine, 6-TG
- Ticlopidine
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Valproic Acid, Divalproex Sodium
- Venetoclax
- Verapamil
- Voriconazole
