Phenazopyridine

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Phenazopyridine Brand Names

AZO | Azo-100 | Azo-Gesic | Azo-Septic | Azo-Standard | Phenazo | Prodium | Pyridium | Urinary Analgesic | Uristat | Uristat Ultra

What is Phenazopyridine

Phenazopyridine is an oral urinary tract analgesic. It is used for the symptomatic relief of pain, burning, urgency, frequency, and other discomforts resulting from irritation of the lower urinary tract mucosa, including symptomatic relief of urinary tract infection (UTI) symptoms.

Phenazopyridine is an azo dye that is excreted in the urine; thus, the urine is discolored orange or red during use.

The use of phenazopyridine for the relief of urinary symptoms should not delay definitive diagnosis and treatment of causative conditions; prompt appropriate treatment of the cause of pain must be instituted.

Phenazopyridine may be used with antibacterial therapy and can help to relieve pain and discomfort during the interval before antibacterial therapy controls the UTI.

Treatment of the symptoms of a UTI with phenazopyridine should not exceed 2 days because there is a lack of evidence that the combined administration with an antibacterial provides greater benefit than administration of the antibacterial alone after 2 days.

Phenazopyridine is available in prescription and non-prescription dosage forms and has been used clinically for decades.

Rare cases of methemoglobinemia and hemolytic anemia have been reported with use of phenazopyridine; patients with G6PD deficiency or with renal insufficiency should not take phenazopyridine.

Indications

  • dysuria
  • urinary urgency

For the symptomatic relief of dysuria, urinary urgency, irritation, and other discomforts of the lower urinary tract caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters

Side Effects

  1. anaphylactoid reactions
  2. aseptic meningitis
  3. contact lens discoloration
  4. elevated hepatic enzymes
  5. eosinophilia
  6. fever
  7. headache
  8. hemolytic anemia
  9. hepatitis
  10. jaundice
  11. methemoglobinemia
  12. pruritus
  13. rash
  14. renal tubular necrosis
  15. urine discoloration

Monitoring Parameters

  • glucose-6-phosphate dehydrogenase (G6PD) activity
  • urinalysis

Contraindications

  • breast-feeding
  • contact lenses
  • G6PD deficiency
  • geriatric
  • laboratory test interference
  • pregnancy
  • pregnancy testing
  • renal disease
  • renal failure
  • renal impairment

Phenazopyridine should not be used in patients who have previously exhibited previous phenazopyridine hypersensitivity

Interactions

There are no drug interactions associated with Phenazopyridine products.

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