Pertuzumab Brand Name– PERJETA
What is Pertuzumab
Pertuzumab is a humanized recombinant monoclonal antibody that blocks ligand-dependent heterodimerization of human epidermal growth factor receptor-2 (HER2) and other epidermal growth factor receptors resulting in the inhibition of intracellular signaling pathways and eventually cell growth arrest and apoptosis.
Pertuzumab also demonstrates antibody-dependent cell-mediated cytotoxicity.
It was FDA-approved in 2012 for the first-line treatment of HER2-positive metastatic breast cancer in combination with trastuzumab and docetaxel based on a significant improvement in progression-free survival compared with placebo.
Since then, the indication has been expanded to include neoadjuvant treatment of HER2-positive, locally advanced, inflammatory, or early stage breast cancer in combination with trastuzumab and docetaxel as part of a complete regimen for early breast cancer, as well as for the adjuvant treatment of HER2-positive early breast cancer at high risk of recurrence.
Indications
- breast cancer
For the treatment of HER2-positive breast cancer
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- alopecia
- anaphylactoid reactions
- anemia
- anemia
- angioedema
- anorexia
- anorexia
- antibody formation
- arthralgia
- arthralgia
- asthenia
- asthenia
- back pain
- bone pain
- bone pain
- chills
- constipation
- constipation
- cough
- cough
- cytokine release syndrome
- diarrhea
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dysgeusia
- dyspepsia
- dyspepsia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- epistaxis
- epistaxis
- fatigue
- fatigue
- fetal death
- fever
- fever
- gastroesophageal reflux
- headache
- headache
- heart failure
- hot flashes
- hot flashes
- hyperphosphatemia
- hyperuricemia
- hypokalemia
- infection
- infection
- infusion-related reactions
- infusion-related reactions
- insomnia
- insomnia
- lacrimation
- leukopenia
- leukopenia
- myalgia
- myalgia
- nausea
- nausea
- neutropenia
- neutropenia
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- paresthesias
- paresthesias
- peripheral edema
- peripheral edema
- peripheral neuropathy
- peripheral neuropathy
- pharyngitis
- pharyngitis
- pleural effusion
- pruritus
- pruritus
- radiation recall reaction
- radiation recall reaction
- rash
- rash
- renal failure (unspecified)
- stomatitis
- stomatitis
- teratogenesis
- thrombocytopenia
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vomiting
- vomiting
- xerosis
- xerosis
Monitoring Parameters
- ejection fraction
- pregnancy testing
Contraindications
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- contraception requirements
- heart failure
- hypertension
- infusion-related reactions
- intrauterine fetal death
- myocardial infarction
- pregnancy
- pregnancy testing
- radiation therapy
- reproductive risk
- tumor lysis syndrome (TLS)
- ventricular dysfunction
Interactions
- Clozapine
- Palifermin
- Penicillamine
- Tuberculin Purified Protein Derivative, PPD
