Pertuzumab

Sharing is caring!

Pertuzumab Brand Name– PERJETA

What is Pertuzumab

Pertuzumab is a humanized recombinant monoclonal antibody that blocks ligand-dependent heterodimerization of human epidermal growth factor receptor-2 (HER2) and other epidermal growth factor receptors resulting in the inhibition of intracellular signaling pathways and eventually cell growth arrest and apoptosis.

Pertuzumab also demonstrates antibody-dependent cell-mediated cytotoxicity.

It was FDA-approved in 2012 for the first-line treatment of HER2-positive metastatic breast cancer in combination with trastuzumab and docetaxel based on a significant improvement in progression-free survival compared with placebo.

Since then, the indication has been expanded to include neoadjuvant treatment of HER2-positive, locally advanced, inflammatory, or early stage breast cancer in combination with trastuzumab and docetaxel as part of a complete regimen for early breast cancer, as well as for the adjuvant treatment of HER2-positive early breast cancer at high risk of recurrence.

Indications

  • breast cancer

For the treatment of HER2-positive breast cancer

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. alopecia
  4. alopecia
  5. anaphylactoid reactions
  6. anemia
  7. anemia
  8. angioedema
  9. anorexia
  10. anorexia
  11. antibody formation
  12. arthralgia
  13. arthralgia
  14. asthenia
  15. asthenia
  16. back pain
  17. bone pain
  18. bone pain
  19. chills
  20. constipation
  21. constipation
  22. cough
  23. cough
  24. cytokine release syndrome
  25. diarrhea
  26. diarrhea
  27. dizziness
  28. dizziness
  29. dysgeusia
  30. dysgeusia
  31. dyspepsia
  32. dyspepsia
  33. dyspnea
  34. dyspnea
  35. elevated hepatic enzymes
  36. elevated hepatic enzymes
  37. epistaxis
  38. epistaxis
  39. fatigue
  40. fatigue
  41. fetal death
  42. fever
  43. fever
  44. gastroesophageal reflux
  45. headache
  46. headache
  47. heart failure
  48. hot flashes
  49. hot flashes
  50. hyperphosphatemia
  51. hyperuricemia
  52. hypokalemia
  53. infection
  54. infection
  55. infusion-related reactions
  56. infusion-related reactions
  57. insomnia
  58. insomnia
  59. lacrimation
  60. leukopenia
  61. leukopenia
  62. myalgia
  63. myalgia
  64. nausea
  65. nausea
  66. neutropenia
  67. neutropenia
  68. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  69. palmar-plantar erythrodysesthesia (hand and foot syndrome)
  70. paresthesias
  71. paresthesias
  72. peripheral edema
  73. peripheral edema
  74. peripheral neuropathy
  75. peripheral neuropathy
  76. pharyngitis
  77. pharyngitis
  78. pleural effusion
  79. pruritus
  80. pruritus
  81. radiation recall reaction
  82. radiation recall reaction
  83. rash
  84. rash
  85. renal failure (unspecified)
  86. stomatitis
  87. stomatitis
  88. teratogenesis
  89. thrombocytopenia
  90. thrombocytopenia
  91. tumor lysis syndrome (TLS)
  92. vomiting
  93. vomiting
  94. xerosis
  95. xerosis

Monitoring Parameters

  • ejection fraction
  • pregnancy testing

Contraindications

  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • contraception requirements
  • heart failure
  • hypertension
  • infusion-related reactions
  • intrauterine fetal death
  • myocardial infarction
  • pregnancy
  • pregnancy testing
  • radiation therapy
  • reproductive risk
  • tumor lysis syndrome (TLS)
  • ventricular dysfunction

Interactions

  • Clozapine
  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD

Sharing is caring!

What is recurrence

What is recurrence?  Recurrence refers to an initial reduction in...

You cannot copy content of this page

shares
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top