Perphenazine and Amitriptyline

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Perphenazine and Amitriptyline Brand Names- Etrafon | Etrafon-A | Triavil

What is Perphenazine and Amitriptyline

Perphenazine and amitriptyline is an oral combination product containing a phenothiazine antipsychotic (perphenazine) and a tricyclic antidepressant (amitriptyline).

Perphenazine and amitriptyline is indicated in patients with schizophrenia and associated depressive symptoms.

This combination is also used for combined depression with moderate to severe anxiety and/or agitation.

As with all antipsychotics and antidepressants, the product label includes a boxed warning regarding an increased mortality risk in elderly patients with dementia-related psychosis receiving an antipsychotic and regarding an increased risk of suicidality in children, adolescents, and young adults in the early phase of treatment with an antidepressant. Perphenazine; amitriptyline was approved by the FDA before 1982.

Clinically, the usefulness of this product is limited by the inability to titrate the dose of the individual components and the availability of newer antipsychotics and antidepressants with a relative increase in tolerability in many patients.

Indications

  1. agitation
  2. anxiety
  3. depression
  4. schizophrenia

For the treatment of depression in patients with moderate to severe anxiety and/or agitation

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. akathisia
  4. alopecia
  5. anaphylactoid reactions
  6. anorexia
  7. anxiety
  8. aplastic anemia
  9. ataxia
  10. blurred vision
  11. breast enlargement
  12. cholestasis
  13. coma
  14. confusion
  15. constipation
  16. corneal opacification
  17. cycloplegia
  18. depression
  19. diarrhea
  20. dizziness
  21. drowsiness
  22. dysarthria
  23. dystonic reaction
  24. edema
  25. EEG changes
  26. ejaculation dysfunction
  27. eosinophilia
  28. erythema
  29. exfoliative dermatitis
  30. fatigue
  31. galactorrhea
  32. gynecomastia
  33. hallucinations
  34. headache
  35. heart failure
  36. hemolytic anemia
  37. hyperprolactinemia
  38. hyperreflexia
  39. hypertension
  40. hyperthermia
  41. hypothermia
  42. ileus
  43. impotence (erectile dysfunction)
  44. increased urinary frequency
  45. insomnia
  46. jaundice
  47. laryngeal edema
  48. leukopenia
  49. libido decrease
  50. mania
  51. mastalgia
  52. menstrual irregularity
  53. mydriasis
  54. myocardial infarction
  55. nausea
  56. neuroleptic malignant syndrome
  57. neuroleptic malignant syndrome-like symptoms
  58. neutropenia
  59. ocular hypertension
  60. orthostatic hypotension
  61. palpitations
  62. pancytopenia
  63. paresthesias
  64. peripheral neuropathy
  65. photophobia
  66. photosensitivity
  67. polydipsia
  68. PR prolongation
  69. priapism
  70. pruritus
  71. pseudoparkinsonism
  72. purpura
  73. QT prolongation
  74. rash
  75. retinopathy
  76. seizures
  77. serotonin syndrome
  78. SIADH
  79. skin hyperpigmentation
  80. stroke
  81. suicidal ideation
  82. tardive dyskinesia
  83. testicular swelling
  84. thrombocytopenia
  85. tinnitus
  86. torsade de pointes
  87. tremor
  88. urinary incontinence
  89. urinary retention
  90. urticaria
  91. vasculitis
  92. ventricular tachycardia
  93. visual impairment
  94. vomiting
  95. water intoxication
  96. weakness
  97. weight gain
  98. withdrawal
  99. xerostomia

Monitoring Parameters

  • AIMS assessment
  • blood pressure
  • CBC
  • ECG
  • heart rate
  • LFTs
  • ophthalmologic exam
  • pregnancy testing
  • serum amitriptyline concentrations
  • serum prolactin

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • agranulocytosis
  • alcoholism
  • ambient temperature increase
  • angina
  • anticholinergic medications
  • asthma
  • AV block
  • bipolar disorder
  • bone marrow suppression
  • breast cancer
  • breast-feeding
  • bundle-branch block
  • carbamazepine hypersensitivity
  • cardiac arrhythmias
  • cardiac disease
  • chemotherapy
  • children
  • closed-angle glaucoma
  • CNS depression
  • coma
  • constipation
  • contact lenses
  • dehydration
  • dementia
  • dental work
  • diabetes mellitus
  • driving or operating machinery
  • dysphagia
  • encephalopathy
  • ethanol intoxication
  • fever
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI disease
  • GI obstruction
  • head trauma
  • hematological disease
  • hepatic disease
  • hyperprolactinemia
  • hyperthermia
  • hyperthyroidism
  • hypothermia
  • hypothyroidism
  • hypovolemia
  • ileus
  • increased intraocular pressure
  • infection
  • infertility
  • intracranial mass
  • jaundice
  • labor
  • leukopenia
  • mania
  • MAOI therapy
  • neonates
  • neutropenia
  • obstetric delivery
  • ocular disease
  • orthostatic hypotension
  • Parkinson’s disease
  • phenothiazine hypersensitivity
  • pregnancy
  • pregnancy testing
  • prostatic hypertrophy
  • pulmonary disease
  • QT prolongation
  • radiographic contrast administration
  • renal failure
  • Reye’s syndrome
  • seizure disorder
  • seizures
  • strenuous exercise
  • stroke
  • suicidal ideation
  • sunlight (UV) exposure
  • surgery
  • tardive dyskinesia
  • tobacco smoking
  • tricyclic antidepressant hypersensitivity
  • urinary retention
  • vomiting

Interactions

  • Abarelix
  • Abiraterone
  • Acarbose
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Acetylcholine Chloride
  • Acrivastine; Pseudoephedrine
  • Albendazole
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amantadine
  • Ambenonium Chloride
  • Amifampridine
  • Amikacin
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminoglycosides
  • Aminolevulinic Acid
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Anagrelide
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Apraclonidine
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Azithromycin
  • Baclofen
  • Barbiturates
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Bepridil
  • Beta-agonists
  • Bethanechol
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Brexpiprazole
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brivaracetam
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cabergoline
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cenobamate
  • Central-acting adrenergic agents
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Cetrorelix
  • Cevimeline
  • Charcoal
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cholinergic agonists
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clindamycin; Tretinoin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Crizotinib
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dacomitinib
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Desflurane
  • Desipramine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Dienogest; Estradiol valerate
  • Diethylpropion
  • Diethylstilbestrol, DES
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxepin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Edrophonium
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encainide
  • Encorafenib
  • Enflurane
  • Entacapone
  • Entrectinib
  • Ephedrine
  • Epinephrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eribulin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Eslicarbazepine
  • Estazolam
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estrogens
  • Estropipate
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Ethotoin
  • Etomidate
  • Everolimus
  • Ezogabine
  • Fedratinib
  • Felbamate
  • Fenfluramine
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fingolimod
  • Flavoxate
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Flucytosine
  • Flumazenil
  • Fluocinolone; Hydroquinone; Tretinoin
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • food
  • Fosamprenavir
  • Foscarnet
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Fospropofol
  • Fostemsavir
  • Gabapentin
  • Galantamine
  • Ganirelix
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gentamicin
  • Gilteritinib
  • Givosiran
  • Glasdegib
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Goserelin
  • Granisetron
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Guanidine
  • Guselkumab
  • Halobetasol; Tazarotene
  • Halofantrine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Ibutilide
  • Idelalisib
  • Iloperidone
  • Imatinib
  • Imipramine
  • Incretin Mimetics
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Inotuzumab Ozogamicin
  • Insulins
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  • Iohexol
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  • Iopromide
  • Ioversol
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  • Isavuconazonium
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  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isosulfan Blue
  • Itraconazole
  • Ivosidenib
  • Ixabepilone
  • Kanamycin
  • Ketamine
  • Ketoconazole
  • Labetalol
  • Lacosamide
  • Lamotrigine
  • Lanthanum Carbonate
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levetiracetam
  • Levocetirizine
  • Levodopa
  • Levofloxacin
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Lisdexamfetamine
  • Lithium
  • Lofexidine
  • Lomefloxacin
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Lorcaserin
  • Loxapine
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Mefloquine
  • Meglitinides
  • Melatonin
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Meprobamate
  • Mequinol; Tretinoin
  • Mesoridazine
  • Mestranol; Norethindrone
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methohexital
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  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylphenidate
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Metronidazole
  • Metyrapone
  • Metyrosine
  • Mexiletine
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Miglitol
  • Milnacipran
  • Minocycline
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Naltrexone
  • Naproxen; Pseudoephedrine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Neostigmine
  • Nicotine
  • Nilotinib
  • Nitroglycerin
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxazepam
  • Oxcarbazepine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Paromomycin
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pemoline
  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Photosensitizing agents (topical)
  • Physostigmine
  • Pilocarpine
  • Pimavanserin
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Pitolisant
  • Plazomicin
  • Porfimer
  • Posaconazole
  • Pralidoxime
  • Pramipexole
  • Pramlintide
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primaquine
  • Primidone
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propofol
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Pseudoephedrine
  • Pyridostigmine
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Racepinephrine
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Rivastigmine
  • Rolapitant
  • Romidepsin
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Rufinamide
  • Safinamide
  • Saquinavir
  • Saxagliptin
  • Scopolamine
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Selpercatinib
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Short-acting beta-agonists
  • Sibutramine
  • Simeprevir
  • Simvastatin; Sitagliptin
  • Siponimod
  • Sitagliptin
  • Sodium Oxybate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • St. John’s Wort, Hypericum perforatum
  • Streptomycin
  • Sufentanil
  • Sulfonylureas
  • Sunitinib
  • Suvorexant
  • Tacrine
  • Tacrolimus
  • Tamoxifen
  • Tamsulosin
  • Tapentadol
  • Tazarotene
  • Tedizolid
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Terbinafine
  • Terfenadine
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Tiagabine
  • Timolol
  • tobacco
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tolcapone
  • Tolterodine
  • Topiramate
  • Toremifene
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Tretinoin, ATRA
  • Triazolam
  • Triclabendazole
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Triptorelin
  • Trospium
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vandetanib
  • Vardenafil
  • Vasopressin, ADH
  • Vemurafenib
  • Venlafaxine
  • Verteporfin
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vorinostat
  • Vortioxetine
  • Yohimbine
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
  • Zonisamide

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