What are p38 kinase inhibitors?
The p38 mitogen-activated protein kinases are responsive to stress stimuli, such as cytokines, resulting in inflammation. Inhibition of these kinases is antiinflammatory. They have potential utility in autoimmune disease and inflammatory states; however, clinical trials to date have not been successful. Inhibition may result in prolonged QTc interval and will be contraindicated in patients at risk for arrhythmias.