Main drugs for maintenance therapy

What are the main drugs used for maintenance therapy?

  • 1. Calcineurin inhibitors (CNI): tacrolimus, cyclosporine
  • 2. Anti-metabolites: azathioprine, mycophenolate mofetil (MMF), and mycophenolic acid (MPA)
  • 3. mTOR (mammalian target of rapamycin) inhibitors: rapamycin and everolimus
  • 4. Corticosteroids
  • 5. Selective co-stimulation blockade: belatacept

The most frequently used combination today is tacrolimus, anti-metabolite (MMF or MPA), and prednisone.

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