Oxybutynin

Oxybutynin Brand Names

ANTUROL | Ditropan | Ditropan XL | Gelnique | Oxytrol | Oxytrol for Women

What is Oxybutynin

Oxybutynin is an oral and transdermal, synthetic drug with chemical and pharmacological properties similar to some anticholinergic, antispasmodic, local anesthetic and antihistaminic compounds.

Oxybutynin is regularly used for patients with neurogenic bladder.

The efficacy of oxybutynin in clinical trials has been demonstrated primarily in outpatient adults, as evidenced by reductions in urge incontinence episodes and total number of voids.

However, one study of elderly nursing home residents revealed that oxybutynin was no better than placebo for reducing the frequency of incontinent episodes, although daytime urinary frequency was reduced.

Oxybutynin (Ditropan) was approved by the FDA in 1975. A sustained-release dosage form (Ditropan XL) was approved in 1999.

A transdermal formulation (Oxytrol) was approved February 2003, a 10% topical gel formulation (Gelnique) was approved January 2009, and a 3% topical gel (Anturol) was approved December 2011.

In January 2013, the transdermal formulation (Oxytrol), was approved for non-prescription use (over-the-counter) treatment of overactive bladder in women >= 18 years; the product will continue to be available for men by prescription only.

Indications

• neurogenic bladder
• overactive bladder (OAB)
• urinary incontinence

For the treatment of an overactive bladder (OAB) with symptoms of urinary frequency, urinary urgency, or urinary incontinence due to involuntary detrusor muscle contractions (includes neurogenic bladder)

Side Effects

1. abdominal pain
2. agitation
3. anaphylactoid reactions
4. angioedema
5. anhidrosis
6. anorexia
7. arrhythmia exacerbation
8. arthralgia
9. asthenia
10. ataxia
11. back pain
12. blurred vision
13. bronchospasm
14. chest pain (unspecified)
15. confusion
16. constipation
17. contact dermatitis
18. cough
19. cycloplegia
20. cystitis
21. delirium
22. diarrhea
23. dizziness
24. drowsiness
25. dysgeusia
26. dyspepsia
27. dysphagia
28. dysphonia
29. dysuria
30. edema
31. eructation
32. erythema
33. fatigue
34. fever
35. flank pain
36. flatulence
37. fluid retention
38. flushing
39. gastroesophageal reflux
40. hallucinations
41. headache
42. hoarseness
43. hyperglycemia
44. hypertension
45. impotence (erectile dysfunction)
46. increased urinary frequency
47. infection
48. insomnia
49. keratoconjunctivitis
50. lactation suppression
51. maculopapular rash
52. memory impairment
53. mydriasis
54. nasal congestion
55. nasal dryness
56. nausea
57. nystagmus
58. ocular hypertension
59. ocular irritation
60. ocular pain
61. palpitations
62. peripheral edema
63. pharyngitis
64. polydipsia
65. pruritus
66. psychosis
67. QT prolongation
68. rash
69. rhinitis
70. seizures
71. sinus tachycardia
72. skin irritation
73. urinary retention
74. urticaria
75. vesicular rash
76. visual impairment
77. vomiting
78. xerophthalmia
79. xerosis
80. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• accidental exposure
• ambient temperature increase
• angioedema
• anticholinergic medications
• autonomic neuropathy
• breast-feeding
• closed-angle glaucoma
• contact lenses
• dementia
• driving or operating machinery
• esophageal stricture
• ethanol ingestion
• gastroesophageal reflux disease (GERD)
• gastroparesis
• geriatric
• GI obstruction
• hepatic disease
• hiatal hernia
• ileus
• infants
• myasthenia gravis
• Parkinson’s disease
• pregnancy
• prostatic hypertrophy
• pyloric stenosis
• tobacco smoking
• toxic megacolon
• ulcerative colitis
• urinary retention
• urinary tract obstruction

Interactions

• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Tramadol
• Aclidinium
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albuterol; Ipratropium
• Alfentanil
• Alosetron
• Alprazolam
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Ambenonium Chloride
• Amitriptyline; Chlordiazepoxide
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amprenavir
• Antacids
• Antidiarrheals
• Anxiolytics; Sedatives; and Hypnotics
• Aprepitant, Fosaprepitant
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Boceprevir
• Bosentan
• Botulinum Toxins
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Dextromethorphan; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chloral Hydrate
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Cholinergic agonists
• Cisapride
• Clarithromycin
• Clemastine
• Clonazepam
• Clorazepate
• Clozapine
• Cobicistat
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Crizotinib
• Crofelemer
• Cyclizine
• Cyclobenzaprine
• Cyproheptadine
• Danazol
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Desmopressin
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Edrophonium
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elbasvir; Grazoprevir
• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Erythromycin
• Erythromycin; Sulfisoxazole
• Estazolam
• Eszopiclone
• Ethanol
• Ethotoin
• Ezogabine
• Fedratinib
• Fentanyl
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluticasone; Umeclidinium; Vilanterol
• Fluvoxamine
• Fosamprenavir
• Fosphenytoin
• Galantamine
• Glucagon
• Glycopyrronium
• grapefruit juice
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Homatropine; Hydrocodone
• Hydantoins
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroquinone
• Hydroxyzine
• Ibuprofen; Oxycodone
• Idelalisib
• Imatinib
• Indinavir
• Ipratropium
• Isavuconazonium
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Itraconazole
• Ketoconazole
• Lefamulin
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Levocetirizine
• Levodopa
• Levorphanol
• Linaclotide
• Loop diuretics
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorazepam
• Loxapine
• Lubiprostone
• Luliconazole
• Lumacaftor; Ivacaftor
• Lurasidone
• Macimorelin
• Magnesium Hydroxide
• Maprotiline
• Meclizine
• Memantine
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Methacholine
• Methadone
• Methohexital
• Metoclopramide
• Midazolam
• Mifepristone
• Mirabegron
• Mirtazapine
• Mitotane
• Molindone
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nalbuphine
• Nefazodone
• Nelfinavir
• Neostigmine
• Nitrofurantoin
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Ondansetron
• Oritavancin
• Orphenadrine
• Oxazepam
• Oxycodone
• Oxymorphone
• Paroxetine
• Pazopanib
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perphenazine
• Perphenazine; Amitriptyline
• Phenobarbital
• Phentermine; Topiramate
• Phenylephrine; Promethazine
• Phenytoin
• Physostigmine
• Posaconazole
• Potassium
• Potassium-sparing diuretics
• Pramlintide
• Primidone
• Procainamide
• Prochlorperazine
• Promethazine
• Protease inhibitors
• Proton pump inhibitors
• Pyridostigmine
• Quazepam
• Quetiapine
• Quinidine
• Rasagiline
• Remifentanil
• Revefenacin
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifamycins
• Rifapentine
• Ritonavir
• Rivastigmine
• Saquinavir
• Secobarbital
• Secretin
• Sedating H1-blockers
• Simeprevir
• Sincalide
• Sodium Bicarbonate
• Solifenacin
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sunscreens
• Tacrine
• Tapentadol
• Tegaserod
• Telaprevir
• Telithromycin
• Telotristat Ethyl
• Temazepam
• Thiazide diuretics
• Thiopental
• Thioridazine
• Thiothixene
• Tiotropium
• Tiotropium; Olodaterol
• Tipranavir
• Tolterodine
• Topiramate
• Tramadol
• Trandolapril; Verapamil
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium
• Umeclidinium; Vilanterol
• Vemurafenib
• Verapamil
• Voriconazole
• Zafirlukast
• Zaleplon
• Zileuton
• Zolpidem
• Zonisamide