Omeprazole Amoxicillin Rifabutin Brand Name– TALICIA
What is Omeprazole Amoxicillin Rifabutin
Omeprazole Amoxicillin Rifabutin is an oral 3-drug combination of a proton pump inhibitor (PPI), a penicillin antibacterial, and a rifamycin antibacterial indicated for the eradication of H. pylori infection in adults.
H. pylori testing is recommended for patients with active peptic ulcer disease (PUD) and those with defined risk factors. Combination eradication therapy is recommended for patients found to be H. pylori positive.
Eradication of H. pylori may decrease symptoms and reduce the risk of further disease development, including gastric cancer.
Omeprazole and almost all antibacterial agents, including amoxicillin and rifabutin, have been associated with pseudomembranous colitis or C. difficile-associated diarrhea (CDAD) which may range in severity from mild to life-threatening.
Treatment with proton pump inhibitors (PPIs) and antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.
Also, treatment with PPIs may lead to a slightly increased risk of gastrointestinal infections due to other pathogens such as Salmonella sp. and Campylobacter sp.
Indications
- Helicobacter pylori
- Helicobacter pylori (H. pylori) eradication
Side Effects
- abdominal pain
- abnormal dreams
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anxiety
- arthralgia
- asthenia
- back pain
- blurred vision
- bone fractures
- bradycardia
- candidiasis
- chest pain (unspecified)
- cholestasis
- colitis
- confusion
- constipation
- contact lens discoloration
- cough
- crystalluria
- depression
- diarrhea
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dyspnea
- eosinophilia
- epistaxis
- eructation
- erythema multiforme
- exfoliative dermatitis
- fever
- flatulence
- gastric polyps
- gastroesophageal reflux
- glycosuria
- gynecomastia
- hallucinations
- headache
- hematuria
- hemolysis
- hemolytic anemia
- hepatic encephalopathy
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperactivity
- hyperhidrosis
- hypertension
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- increased urinary frequency
- infection
- insomnia
- interstitial nephritis
- jaundice
- leukocytosis
- leukopenia
- lupus-like symptoms
- lymphopenia
- maculopapular rash
- migraine
- muscle cramps
- myalgia
- nausea
- neutropenia
- ocular irritation
- optic atrophy
- optic neuritis
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peripheral edema
- petechiae
- photosensitivity
- proteinuria
- pruritus
- pseudomembranous colitis
- purpura
- pyuria
- rash
- seizures
- serum sickness
- sinus tachycardia
- skin discoloration
- Stevens-Johnson syndrome
- stomatitis
- stool discoloration
- superinfection
- testicular pain
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- toxic epidermal necrolysis
- tremor
- urine discoloration
- urticaria
- uveitis
- vaginal discharge
- vasculitis
- vertigo
- vomiting
- weakness
- weight gain
- xerosis
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- Asian patients
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- contact lenses
- diarrhea
- geriatric
- hepatic disease
- infertility
- laboratory test interference
- mononucleosis
- osteopenia
- osteoporosis
- penicillin hypersensitivity
- poor metabolizers
- pregnancy
- proton pump inhibitors (PPIs) hypersensitivity
- pseudomembranous colitis
- renal failure
- renal impairment
- reproductive risk
- rifamycin hypersensitivity
- systemic lupus erythematosus (SLE)
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
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- Abiraterone
- Acalabrutinib
- Acetaminophen
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- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
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