Olodaterol Brand Name– Striverdi Respimat
What is Olodaterol
Olodaterol is an inhaled long-acting beta-2 adrenergic agonist (LABA) that is given once daily.
It is indicated for the maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (COPD).
According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for COPD, LABAs may be used as initial monotherapy in patients in Groups A and B. In Group C patients, long-acting muscarinic antagonists (LAMA) are preferred as initial therapy over LABAs due to effectiveness in preventing exacerbations. In Group D patients, LABAs are used as initial therapy in combination with inhaled corticosteroids (ICS) or LAMAs.
At follow-up, if the patient is still experiencing dyspnea, consider switching inhaler device and investigate for other causes of dyspnea. If the patient has exacerbations, consider triple therapy with a LAMA, a LABA, and ICS.
Olodaterol is not indicated for the treatment of asthma and should not be used for acute bronchospasm.
The FDA first approved olodaterol in 2014.
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
- emphysema
For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema
Side Effects
- arrhythmia exacerbation
- arthralgia
- asthma-related death
- atrial fibrillation
- back pain
- bronchospasm
- constipation
- cough
- diarrhea
- dizziness
- fever
- hyperglycemia
- hypokalemia
- infection
- new primary malignancy
- pharyngitis
- QT prolongation
- rash
- ST-T wave changes
- wheezing
Monitoring Parameters
- pulmonary function tests (PFTs)
Contraindications
- acute bronchospasm
- apheresis
- asthma
- asthma-related death
- AV block
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiomyopathy
- celiac disease
- children
- diabetes mellitus
- females
- fever
- geriatric
- heart failure
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypertension
- hyperthyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- infants
- labor
- long QT syndrome
- MAOI therapy
- monotherapy treatment of asthma
- myocardial infarction
- paradoxical bronchospasm
- pheochromocytoma
- pregnancy
- QT prolongation
- rheumatoid arthritis
- seizure disorder
- seizures
- sickle cell disease
- sleep deprivation
- stroke
- systemic lupus erythematosus (SLE)
- thyrotoxicosis
Interactions
- Abarelix
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Aclidinium; Formoterol
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Apomorphine
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Azithromycin
- Bedaquiline
- Bendroflumethiazide; Nadolol
- Beta-adrenergic blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brimonidine; Timolol
- Budesonide; Formoterol
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Caffeine
- Caffeine; Ergotamine
- Carteolol
- Carvedilol
- Ceritinib
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- Clarithromycin
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- Clozapine
- Cocaine
- Codeine; Phenylephrine; Promethazine
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- Dasatinib
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- Deutetrabenazine
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- Donepezil
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- Dorzolamide; Timolol
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- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Ethacrynic Acid
- Ezogabine
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
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- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Furosemide
- Gemifloxacin
- Gemtuzumab Ozogamicin
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- Halofantrine
- Haloperidol
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- Histrelin
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Isocarboxazid
- Isoflurane
- Ivosidenib
- Ketoconazole
- Labetalol
- Lapatinib
- Lefamulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levobetaxolol
- Levobunolol
- Levofloxacin
- Levomethadyl
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linezolid
- Liothyronine
- Lithium
- Lofexidine
- Lomefloxacin
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
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- Metronidazole
- Midostaurin
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- Monoamine oxidase inhibitors
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- Pazopanib
- Penbutolol
- Pentamidine
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- Pitolisant
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- Procainamide
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- Quetiapine
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