What is Tiotropium and Olodaterol medicine combination
Tiotropium and olodaterol is a combination inhalation containing a long-acting muscarinic antagonist (LAMA), (tiotropium) and a long-acting beta-2 adrenergic agonist (LABA), (olodaterol) that is administered once daily.
The combination is used for the maintenance treatment of airflow obstruction in adults with chronic obstructive pulmonary disease (COPD).
According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, such combinations may be used as initial therapy in patients in group D (those with a high risk of exacerbation).
Tiotropium has been shown to reduce COPD exacerbations and related hospitalizations. Long-acting beta-2 adrenergic agonists (LABAs) like olodaterol have also been associated with a reduced COPD exacerbation rate.
Combining bronchodilators with different mechanisms of action may further improve patient symptoms with a lower risk of adverse events compared to increasing the dose of a single bronchdilator.
Combination bronchodilators have a greater impact on patient reported outcomes and quality of life compared to monotherapies; however, more studies are needed to determine if combination therapy is more effective at preventing exacerbations.
Tiotropium and olodaterol is not indicated for the relief of acute deterioration of COPD, for acute bronchospasm, or for the treatment of asthma. The FDA approved tiotropium; olodaterol inhalation in 2015.
Brand Name
STIOLTO RESPIMAT
Indications
- chronic bronchitis
- chronic obstructive pulmonary disease (COPD)
- emphysema
For the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and/or emphysema
Side Effects
- abdominal pain
- anaphylactoid reactions
- angina
- angioedema
- arrhythmia exacerbation
- arthralgia
- asthma-related death
- atrial fibrillation
- back pain
- blurred vision
- bronchospasm
- candidiasis
- chest pain (unspecified)
- constipation
- cough
- dehydration
- depression
- dizziness
- dyspepsia
- dysphagia
- dysphonia
- dysuria
- epistaxis
- fever
- gastroesophageal reflux
- GI obstruction
- gingivitis
- glossitis
- headache
- hypercholesterolemia
- hyperglycemia
- hypertension
- hypokalemia
- ileus
- infection
- insomnia
- laryngitis
- musculoskeletal pain
- myalgia
- ocular hypertension
- ocular irritation
- ocular pain
- palpitations
- paresthesias
- peripheral edema
- pharyngitis
- pruritus
- QT prolongation
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- skin ulcer
- ST-T wave changes
- stomatitis
- supraventricular tachycardia (SVT)
- urinary retention
- urticaria
- visual impairment
- vomiting
- wheezing
- xerosis
- xerostomia
Monitoring Parameters
- pulmonary function tests (PFTs)
Contraindications
- acute bronchospasm
- alcoholism
- anticholinergic medications
- asthma
- asthma-related death
- bladder obstruction
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- closed-angle glaucoma
- contact lenses
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- infants
- labor
- long QT syndrome
- malnutrition
- MAOI therapy
- monotherapy treatment of asthma
- myocardial infarction
- neonates
- ocular exposure
- ophthalmic administration
- paradoxical bronchospasm
- pheochromocytoma
- pregnancy
- prostatic hypertrophy
- QT prolongation
- renal impairment
- seizure disorder
- seizures
- thyroid disease
- thyrotoxicosis
- urinary retention
- urinary tract obstruction
Interactions
- Abarelix
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Aclidinium
- Aclidinium; Formoterol
- Alfuzosin
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Anticholinergics
- Apomorphine
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azithromycin
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Beta-adrenergic blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brimonidine; Timolol
- Budesonide; Formoterol
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Caffeine
- Caffeine; Ergotamine
- Carteolol
- Carvedilol
- Ceritinib
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clozapine
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crizotinib
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Desipramine
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dicyclomine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxepin
- Dronedarone
- Droperidol
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esmolol
- Ethacrynic Acid
- Ezogabine
- Fingolimod
- Flavoxate
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Furosemide
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Halofantrine
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibutilide
- Iloperidone
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Isocarboxazid
- Isoflurane
- Ivosidenib
- Ketoconazole
- Labetalol
- Lapatinib
- Lefamulin
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levobetaxolol
- Levobunolol
- Levofloxacin
- Levomethadyl
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linezolid
- Liothyronine
- Lithium
- Lofexidine
- Lomefloxacin
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Macimorelin
- Maprotiline
- Mefloquine
- Mepenzolate
- Meperidine; Promethazine
- Mesoridazine
- Methacholine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Metoprolol
- Metronidazole
- Midostaurin
- Mifepristone
- Mirtazapine
- Monoamine oxidase inhibitors
- Moxifloxacin
- Nadolol
- Nebivolol
- Nebivolol; Valsartan
- Nilotinib
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxybutynin
- Ozanimod
- Paliperidone
- Panobinostat
- Pasireotide
- Pazopanib
- Penbutolol
- Pentamidine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pindolol
- Pitolisant
- Posaconazole
- Primaquine
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propantheline
- Propranolol
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Racepinephrine
- Ranolazine
- Rasagiline
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Ritonavir
- Romidepsin
- Saquinavir
- Scopolamine
- Selegiline
- Selpercatinib
- Sertraline
- Sevoflurane
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telavancin
- Telithromycin
- Tetrabenazine
- Theophylline, Aminophylline
- Thiazide diuretics
- Thioridazine
- Thyroid hormones
- Timolol
- Tolterodine
- Toremifene
- Torsemide
- Tranylcypromine
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimipramine
- Triptorelin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Ziprasidone
