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Olanzapine Brand Names
Zyprexa | Zyprexa Intramuscular | Zyprexa Relprevv | Zyprexa Zydis
What is Olanzapine
Olanzapine is an atypical antipsychotic similar in chemical structure and mechanism of action to clozapine, but with a lower incidence of side effects, including neutropenia.
Atypical antipsychotics (excluding clozapine) are deemed to be the standard of care for schizophrenia and related disorders. Clinically, olanzapine is effective for the positive and negative symptoms of schizophrenia and for mood stabilization in patients with bipolar I disorder.
The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study evaluated the effectiveness of selected atypical antipsychotics and perphenazine in schizophrenic patients.
The primary outcome measure was discontinuation of treatment for any cause, with secondary outcomes evaluating drug efficacy (determined via the PANSS and CGI scale), adverse event profiles, and reasons for drug discontinuation. For the primary outcome measure, 74% of patients discontinued study medication before 18 months.
The olanzapine group demonstrated a slightly longer time to discontinuation of treatment for any cause compared to the quetiapine or risperidone groups. Secondarily, the duration of successful treatment was significantly longer in the olanzapine and risperidone groups, compared to other atypicals antipsychotics or perphenazine.
The PANSS and CGI scores improved and were similar in all groups. Rates of hospitalizations were lowest in the olanzapine group (11%) vs. other treatment groups (15% to 20%).
However, discontinuation of treatment due to adverse events was greater in the olanzapine group, primarily due to weight gain and metabolic effects.
Compared to haloperidol or lithium, olanzapine is equally effective in achieving remission in bipolar mania.
Olanzapine has been shown to be superior to valproate in a 3-week study of acute bipolar adult patients with mixed or manic episodes, but the decrease in the Hamilton Depression scores were similar.
Olanzapine is FDA-approved for the treatment of schizophrenia and for manic or mixed episodes associated with bipolar I disorder (as monotherapy or in combination with lithium or valproate) in both adults and adolescents, and can be used for the maintenance treatment of bipolar I disorder as monotherapy.
In adults, olanzapine is an effective adjunct to fluoxetine for treatment-refractory depression or for depressive episodes of bipolar I disorder.
An intramuscular injection solution formulation (Zyprexa IntraMuscular) treats acute agitation associated with schizophrenia and bipolar disorder.
An extended-release intramuscular depot formulation (Zyprexa Relprevv) is used for the maintenance treatment of schizophrenia in adults and is administered every 2 to 4 weeks.
Indications
- agitation
- behavioral or psychological symptoms of dementia
- bipolar depression
- bipolar disorder
- chemotherapy-induced nausea/vomiting prophylaxis
- depression
- mania
- schizophrenia
Side Effects
- abdominal pain
- acne vulgaris
- agranulocytosis
- akathisia
- alopecia
- amblyopia
- amenorrhea
- amnesia
- anaphylactoid reactions
- angioedema
- appetite stimulation
- arthralgia
- asthenia
- ataxia
- back pain
- breast discharge
- breast enlargement
- chest pain (unspecified)
- chills
- choreoathetosis
- coma
- confusion
- constipation
- dental caries
- dental pain
- depression
- diabetes mellitus
- diabetic ketoacidosis
- diarrhea
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysarthria
- dyskinesia
- dyspepsia
- dysphagia
- dysphemia
- dyspnea
- dystonic reaction
- ecchymosis
- edema
- ejaculation dysfunction
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- euphoria
- fatigue
- fever
- flatulence
- galactorrhea
- GI obstruction
- gynecomastia
- hallucinations
- headache
- hepatitis
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hyperhidrosis
- hyperlipidemia
- hyperprolactinemia
- hypersalivation
- hypertension
- hypertonia
- hypertriglyceridemia
- hyponatremia
- hypotension
- ileus
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- injection site reaction
- insomnia
- jaundice
- leukopenia
- libido decrease
- lymphadenopathy
- mastalgia
- menorrhagia
- menstrual irregularity
- muscle cramps
- musculoskeletal pain
- mydriasis
- myoclonia
- nasal congestion
- nausea
- neuroleptic malignant syndrome
- neutropenia
- oligomenorrhea
- orgasm dysfunction
- orthostatic hypotension
- osteoporosis
- otalgia
- pancreatitis
- paresthesias
- peripheral edema
- peripheral vasodilation
- pharyngitis
- photosensitivity
- polydipsia
- polyuria
- post-injection delirium/sedation syndrome
- priapism
- pruritus
- pseudoparkinsonism
- pulmonary edema
- pulmonary embolism
- QT prolongation
- restless legs syndrome (RLS)
- restlessness
- rhabdomyolysis
- rhinitis
- seizures
- serotonin syndrome
- SIADH
- sinus tachycardia
- sinusitis
- sneezing
- stroke
- suicidal ideation
- syncope
- tardive dyskinesia
- thrombocytopenia
- thrombosis
- torticollis
- tremor
- urinary incontinence
- urinary retention
- urinary urgency
- urticaria
- vaginal discharge
- vaginitis
- visual impairment
- vomiting
- water intoxication
- weight gain
- withdrawal
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- AIMS assessment
- blood glucose
- blood pressure
- CBC
- glycosylated hemoglobin A1c (HbA1c)
- heart rate
- LFTs
- neurologic function
- pregnancy testing
- serum creatinine
- serum electrolytes
- serum lipid profile
- serum prolactin
- thyroid function tests (TFTs)
- weight
Contraindications
- abrupt discontinuation
- agranulocytosis
- ambient temperature increase
- anticholinergic medications
- apheresis
- Asian patients
- AV block
- bradycardia
- breast cancer
- breast-feeding
- cardiomyopathy
- celiac disease
- cerebrovascular disease
- children
- closed-angle glaucoma
- CNS depression
- coadministration with other CNS depressants
- coma
- constipation
- dehydration
- dementia
- diabetes mellitus
- diabetic ketoacidosis
- driving or operating machinery
- dysphagia
- ethanol ingestion
- females
- fever
- geriatric
- GI obstruction
- heart failure
- hematological disease
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hyperparathyroidism
- hyperprolactinemia
- hyperthermia
- hypertriglyceridemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- hypovolemia
- ileus
- infants
- infertility
- intravenous administration
- leukopenia
- long QT syndrome
- myocardial infarction
- neonates
- neurological disease
- neutropenia
- obesity
- orthostatic hypotension
- Parkinson’s disease
- phenylketonuria
- pheochromocytoma
- post-injection delirium/sedation syndrome
- pregnancy
- pregnancy testing
- prostatic hypertrophy
- QT prolongation
- reproductive risk
- rheumatoid arthritis
- seizure disorder
- seizures
- serious hypersensitivity reactions or anaphylaxis
- serious rash
- sickle cell disease
- sleep deprivation
- strenuous exercise
- stroke
- subcutaneous administration
- suicidal ideation
- systemic lupus erythematosus (SLE)
- tardive dyskinesia
- tobacco smoking
- urinary retention
Interactions
- Abarelix
- Acarbose
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Albendazole
- Albiglutide
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren; Valsartan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amantadine
- Ambenonium Chloride
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Benazepril
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan
- Azilsartan; Chlorthalidone
- Azithromycin
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bepridil
- Beta-adrenergic blockers
- Betaxolol
- Bethanechol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brexpiprazole
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Cabergoline
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Cenobamate
- Central-acting adrenergic agents
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Charcoal
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cimetidine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clemastine
- Clobazam
- Clofazimine
- Clonazepam
- Clorazepate
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Crizotinib
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxazosin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Dulaglutide
- Duloxetine
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Entacapone
- Entrectinib
- Epinephrine
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eribulin
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Esmolol
- Estazolam
- Eszopiclone
- Ethanol
- Ethotoin
- Exenatide
- Ezogabine
- Fenfluramine
- Fenofibric Acid
- Fentanyl
- Fesoterodine
- Fingolimod
- Flavoxate
- Flecainide
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Gabapentin
- Galantamine
- Ganirelix
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Glasdegib
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibutilide
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Irbesartan
- Isocarboxazid
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Labetalol
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levodopa
- Levofloxacin
- Levomethadyl
- Levorphanol
- Linagliptin
- Linagliptin; Metformin
- Liraglutide
- Lisinopril
- Lithium
- Lixisenatide
- Lofexidine
- Long-acting beta-agonists
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorazepam
- Losartan
- Loxapine
- Lumateperone
- Lurasidone
- Macimorelin
- Maprotiline
- Mecamylamine
- Meclizine
- Mefloquine
- Meglitinides
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methscopolamine
- Methylphenidate
- Metoclopramide
- Metoprolol
- Metronidazole
- Mexiletine
- Midazolam
- Midostaurin
- Mifepristone
- Miglitol
- Mirabegron
- Mirtazapine
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nadolol
- Nafarelin
- Nalbuphine
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Non-Ionic Contrast Media
- Norfloxacin
- Obeticholic Acid
- Octreotide
- Ofloxacin
- Olmesartan
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Penbutolol
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phenoxybenzamine
- Phenylephrine; Promethazine
- Phenytoin
- Pimavanserin
- Pimozide
- Pindolol
- Pioglitazone
- Pitolisant
- Posaconazole
- Potassium-sparing diuretics
- Pramipexole
- Pramlintide
- Pregabalin
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Propafenone
- Propantheline
- Propoxyphene
- Propranolol
- Quazepam
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Ramelteon
- Ramipril
- Ranolazine
- Rasagiline
- Remifentanil
- Repaglinide
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rilpivirine
- Risperidone
- Ritonavir
- Rivastigmine
- Rolapitant
- Romidepsin
- Ropinirole
- Rosiglitazone
- Rotigotine
- Sacubitril; Valsartan
- Safinamide
- Salmeterol
- Saquinavir
- Saxagliptin
- Scopolamine
- Secobarbital
- Selegiline
- Selpercatinib
- Semaglutide
- Sertraline
- SGLT2 Inhibitors
- Short-acting beta-agonists
- Sibutramine
- Simeprevir
- Simvastatin; Sitagliptin
- Siponimod
- Sitagliptin
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfonylureas
- Sunitinib
- Suvorexant
- Tacrine
- Tacrolimus
- Tamoxifen
- Tapentadol
- Telavancin
- Telithromycin
- Telmisartan
- Temazepam
- Terazosin
- Tetrabenazine
- Thiabendazole
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Timolol
- Tiotropium; Olodaterol
- tobacco
- Tolcapone
- Tolterodine
- Toremifene
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Triamterene
- Triazolam
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Triprolidine
- Triptorelin
- Trospium
- Umeclidinium; Vilanterol
- Valsartan
- Vandetanib
- Vardenafil
- Vasodilators
- Vemurafenib
- Venlafaxine
- Voriconazole
- Vorinostat
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
- Zonisamide
