Fluoxetine Olanzapine

Fluoxetine Olanzapine Brand Name– Symbyax

What is Fluoxetine Olanzapine

Fluoxetine olanzapine is a combination of an atypical antipsychotic, olanzapine, with a selective serotonin reuptake inhibitor (SSRI), fluoxetine.

Clinically, atypical antipsychotics have been frequently used in combination with SSRIs for a variety of psychiatric disorders.

Olanzapine, when added to an SSRI, can be used adjunctively to help patients with treatment-resistant depression, which is defined as non-response to 2 separate trials of different antidepressants of adequate dose and duration in the current episode.

Olanzapine, as a single agent, is useful for patients with a diagnosis of bipolar I disorder with manic or mixed episodes.

The addition of fluoxetine helps to alleviate bipolar depression better than the use of olanzapine alone. This drug combination was the first FDA-approved combination medication for the treatment of depressive episodes associated with bipolar I disorder.

According to a pivotal study, the combination helped to treat the symptoms of bipolar depression effectively and at a significantly faster rate than placebo; improvement occurred and was maintained during the entire 8 weeks of the trial. Additionally, the treated patients had no statistically greater risk of treatment-emergent mania than those taking placebo (induction of mania is a potential outcome of treatment with antidepressants alone).

Careful titration of dosage is recommended in bipolar patients. The combination of olanzapine; fluoxetine is approved for use in adults treatment-resistant depression.

The product is also approved for depressive episodes associated with bipolar I disorder in adults and pediatric patients 10 years of age and older.

Product labels for all antidepressants contain a boxed warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy with an antidepressant, whether treating depression or other psychiatric conditions.

As with all products containing atypical antipsychotics, there is also a boxed warning regarding increased mortality risk in elderly patients treated for dementia-related psychosis.

The initial FDA-approval of these products was granted in December 2003.

Indications

  • bipolar depression
  • depression

For acute and maintenance treatment of treatment-resistant depression

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. akathisia
  4. alopecia
  5. amenorrhea
  6. amnesia
  7. anaphylactoid reactions
  8. anemia
  9. angioedema
  10. anxiety
  11. aplastic anemia
  12. appetite stimulation
  13. arthralgia
  14. asthenia
  15. ataxia
  16. back pain
  17. bleeding
  18. blurred vision
  19. bone fractures
  20. bradycardia
  21. breast enlargement
  22. bronchospasm
  23. chills
  24. cholestasis
  25. coma
  26. constipation
  27. depression
  28. diabetes mellitus
  29. diarrhea
  30. drowsiness
  31. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  32. dysarthria
  33. dysgeusia
  34. dysmenorrhea
  35. dyspepsia
  36. dysphagia
  37. dysphemia
  38. dystonic reaction
  39. dysuria
  40. ecchymosis
  41. edema
  42. ejaculation dysfunction
  43. elevated hepatic enzymes
  44. emotional lability
  45. eosinophilic pneumonia
  46. epistaxis
  47. erythema multiforme
  48. esophageal ulceration
  49. euphoria
  50. exfoliative dermatitis
  51. fatigue
  52. fever
  53. flatulence
  54. galactorrhea
  55. gastritis
  56. GI bleeding
  57. GI obstruction
  58. gout
  59. gynecomastia
  60. headache
  61. hepatitis
  62. hyperbilirubinemia
  63. hypercholesterolemia
  64. hyperglycemia
  65. hyperhidrosis
  66. hyperkinesis
  67. hyperlipidemia
  68. hyperprolactinemia
  69. hypersalivation
  70. hypertriglyceridemia
  71. hyponatremia
  72. hypotension
  73. ileus
  74. impotence (erectile dysfunction)
  75. increased urinary frequency
  76. insomnia
  77. jaundice
  78. laryngospasm
  79. leukopenia
  80. libido decrease
  81. libido increase
  82. maculopapular rash
  83. mania
  84. mastalgia
  85. menorrhagia
  86. menstrual irregularity
  87. musculoskeletal pain
  88. myoclonia
  89. nausea
  90. neonatal abstinence syndrome
  91. neuroleptic malignant syndrome
  92. neutropenia
  93. orgasm dysfunction
  94. orthostatic hypotension
  95. osteopenia
  96. osteoporosis
  97. pancreatitis
  98. peptic ulcer
  99. peripheral vasodilation
  100. persistent pulmonary hypertension of the newborn
  101. photosensitivity
  102. platelet dysfunction
  103. polydipsia
  104. priapism
  105. pruritus
  106. pseudoparkinsonism
  107. pulmonary embolism
  108. purpura
  109. QT prolongation
  110. rash
  111. restless legs syndrome (RLS)
  112. restlessness
  113. rhabdomyolysis
  114. serotonin syndrome
  115. serum sickness
  116. SIADH
  117. sinus tachycardia
  118. sinusitis
  119. Stevens-Johnson syndrome
  120. stroke
  121. suicidal ideation
  122. syncope
  123. tardive dyskinesia
  124. teeth grinding (bruxism)
  125. thrombocytopenia
  126. thrombosis
  127. toxic epidermal necrolysis
  128. tremor
  129. urinary incontinence
  130. urinary retention
  131. urinary urgency
  132. urticaria
  133. vasculitis
  134. vomiting
  135. water intoxication
  136. weight gain
  137. weight loss
  138. withdrawal
  139. xerophthalmia
  140. xerosis
  141. xerostomia
  142. yawning

Monitoring Parameters

  • AIMS assessment
  • blood glucose
  • CBC
  • glycosylated hemoglobin A1c (HbA1c)
  • LFTs
  • neurologic function
  • pregnancy testing
  • serum creatinine
  • serum electrolytes
  • serum lipid profile
  • serum prolactin
  • thyroid function tests (TFTs)
  • weight

Contraindications

  • abrupt discontinuation
  • agranulocytosis
  • ambient temperature increase
  • anorexia nervosa
  • anticholinergic medications
  • anticoagulant therapy
  • bleeding
  • bone fractures
  • bradycardia
  • breast cancer
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • children
  • closed-angle glaucoma
  • CNS depression
  • coma
  • constipation
  • dehydration
  • dementia
  • diabetes mellitus
  • driving or operating machinery
  • dysphagia
  • electroconvulsive therapy (ECT)
  • electrolyte imbalance
  • ethanol ingestion
  • fever
  • geriatric
  • GI obstruction
  • heart failure
  • hematological disease
  • hepatic disease
  • hepatitis
  • hyperprolactinemia
  • hyperthermia
  • hypokalemia
  • hypomagnesemia
  • hyponatremia
  • hypothermia
  • hypovolemia
  • ileus
  • increased intraocular pressure
  • infertility
  • jaundice
  • leukopenia
  • mania
  • MAOI therapy
  • myocardial infarction
  • neonates
  • neurological disease
  • neutropenia
  • obesity
  • orthostatic hypotension
  • osteoporosis
  • Parkinson’s disease
  • poor metabolizers
  • pregnancy
  • pregnancy testing
  • prostatic hypertrophy
  • QT prolongation
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • strenuous exercise
  • stroke
  • suicidal ideation
  • surgery
  • syncope
  • tachycardia
  • tardive dyskinesia
  • thrombolytic therapy
  • tobacco smoking
  • urinary retention
  • ventricular arrhythmias

Interactions

  • Abarelix
  • Abciximab
  • Abemaciclib
  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Albendazole
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Alteplase
  • Amantadine
  • Ambenonium Chloride
  • Amifampridine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamines
  • Anagrelide
  • Angiotensin II receptor antagonists
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  • Armodafinil
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Azithromycin
  • Barbiturates
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Bepridil
  • Beta-adrenergic blockers
  • Betaxolol
  • Bethanechol
  • Betrixaban
  • Bicalutamide
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Boceprevir
  • Bortezomib
  • Bosentan
  • Brexpiprazole
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cabergoline
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cangrelor
  • Cannabidiol
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Central-acting adrenergic agents
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Cetrorelix
  • Cevimeline
  • Charcoal
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clobazam
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  • Clonazepam
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  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Crizotinib
  • Cyclobenzaprine
  • Cyclosporine
  • Cyproheptadine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darifenacin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dasatinib
  • Degarelix
  • Delavirdine
  • Desflurane
  • Desipramine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Dienogest; Estradiol valerate
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
  • Disopyramide
  • Diuretics
  • Docetaxel
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxepin
  • Doxercalciferol
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dulaglutide
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Edoxaban
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eletriptan
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encainide
  • Encorafenib
  • Enflurane
  • Enoxaparin
  • Entacapone
  • Entrectinib
  • Epinephrine
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Eribulin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Esmolol
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
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  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estropipate
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethotoin
  • Everolimus
  • Exenatide
  • Ezogabine
  • Fedratinib
  • Felodipine
  • Fenfluramine
  • Fenofibric Acid
  • Fentanyl
  • Fesoterodine
  • Fingolimod
  • Flavoxate
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Fluphenazine
  • Flurazepam
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvastatin
  • Fluvoxamine
  • Fondaparinux
  • food
  • Formoterol
  • Formoterol; Mometasone
  • Foscarnet
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
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  • Gefitinib
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  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Goserelin
  • Granisetron
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halofantrine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibutilide
  • Ifosfamide
  • Iloperidone
  • Iloprost
  • Imatinib
  • Imipramine
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
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  • Insulins
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  • Isavuconazonium
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  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isradipine
  • Itraconazole
  • Ivabradine
  • Ivacaftor
  • Ivosidenib
  • Ixabepilone
  • Ketoconazole
  • Labetalol
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  • Leuprolide
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  • Levalbuterol
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  • Levobunolol
  • Levocetirizine
  • Levodopa
  • Levofloxacin
  • Levomefolate
  • Levomethadyl
  • Levomilnacipran
  • Levorphanol
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin
  • Linagliptin; Metformin
  • Linezolid
  • Liraglutide
  • Lisinopril
  • Lithium
  • Lixisenatide
  • Lofexidine
  • Lomitapide
  • Long-acting beta-agonists
  • Loop diuretics
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorazepam
  • Lorcaserin
  • Losartan
  • Low Molecular Weight Heparins
  • Loxapine
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Salicylate
  • Maprotiline
  • Maraviroc
  • Mecamylamine
  • Meclizine
  • Mefloquine
  • Meglitinides
  • Melatonin
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mesoridazine
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methscopolamine
  • Methyclothiazide
  • Methylene Blue
  • Methylergonovine
  • Methylphenidate
  • Methysergide
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Metronidazole
  • Mexiletine
  • Midazolam
  • Midostaurin
  • Mifepristone
  • Miglitol
  • Milnacipran
  • Mirabegron
  • Mirtazapine
  • Modafinil
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Nanoparticle Albumin-Bound Paclitaxel
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nateglinide
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Netupitant, Fosnetupitant; Palonosetron
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nisoldipine
  • Nitroglycerin
  • Non-Ionic Contrast Media
  • Nonsteroidal antiinflammatory drugs
  • Norfloxacin
  • Nortriptyline
  • Obeticholic Acid
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Olmesartan
  • Olodaterol
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paclitaxel
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Paricalcitol
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Penbutolol
  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Pentosan
  • Perampanel
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pimavanserin
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Pitolisant
  • Posaconazole
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Prasugrel
  • Pregabalin
  • Prilocaine; Epinephrine
  • Primaquine
  • Primidone
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinapril
  • Quinidine
  • Quinine
  • Ramelteon
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Repaglinide
  • Reserpine
  • Reteplase, r-PA
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Rivaroxaban
  • Rivastigmine
  • Rizatriptan
  • Rolapitant
  • Romidepsin
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Ruxolitinib
  • Sacubitril; Valsartan
  • Safinamide
  • Salmeterol
  • Salsalate
  • Saquinavir
  • Saxagliptin
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Selpercatinib
  • Semaglutide
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Short-acting beta-agonists
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Simvastatin; Sitagliptin
  • Siponimod
  • Sirolimus
  • Sitagliptin
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptokinase
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Sunitinib
  • Suvorexant
  • Tacrine
  • Tacrolimus
  • Tadalafil
  • Tamoxifen
  • Tamsulosin
  • Tapentadol
  • Tedizolid
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Telmisartan
  • Temazepam
  • Tenecteplase
  • Terazosin
  • Terbinafine
  • Terbutaline
  • Tetrabenazine
  • Tezacaftor; Ivacaftor
  • Thiabendazole
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thrombin Inhibitors
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Timolol
  • Tinzaparin
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tirofiban
  • tobacco
  • Tofacitinib
  • Tolcapone
  • Tolterodine
  • Tolvaptan
  • Topiramate
  • Toremifene
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Triclabendazole
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimipramine
  • Triprolidine
  • Triptorelin
  • Trospium
  • Ubrogepant
  • Ulipristal
  • Umeclidinium; Vilanterol
  • Urokinase
  • Valbenazine
  • Valerian, Valeriana officinalis
  • Valsartan
  • Vandetanib
  • Vardenafil
  • Vasodilators
  • Vasopressin, ADH
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vinblastine
  • Vinorelbine
  • Vorapaxar
  • Voriconazole
  • Vorinostat
  • Vortioxetine
  • Warfarin
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zonisamide
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