Nisoldipine Brand Name– Sular
What is Nisoldipine
Nisoldipine is a long-acting, oral, dihydropyridine calcium-channel blocker that is structurally related to nifedipine. In comparison with nifedipine, nisoldipine has greater affinity and selectivity for vascular smooth muscle, produces 5—10 times greater peripheral vasodilation, and has a longer elimination half-life.
In comparative studies of mild to moderate hypertension, nisoldipine 10 mg once daily was as effective as amlodipine 5 mg once daily.
In chronic stable angina, nisoldipine 20—40 mg once daily was as effective as amlodipine 5—10 mg once daily or immediate release diltiazem 80 mg three times daily.
Nisoldipine was initially FDA-approved for the treatment of hypertension on February 2, 1995 and was available in the US as an extended-release tablet formulation (Sular®), which allowed for once daily dosing for the treatment of hypertension or angina.
In March 2008, the traditional strengths of Sular® extended-release tablets (10, 20, 30, and 40 mg) were commercially replaced with new, lower-strength, bioequivalent formulations (8.5, 17, 25.5, 34 mg) utilizing Geomatrix™ technology.
Indications
- hypertension
- variant angina
Side Effects
- acne vulgaris
- alopecia
- anemia
- angioedema
- arthralgia
- asthenia
- atrial fibrillation
- AV block
- azotemia
- chest pain (unspecified)
- diaphoresis
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- exfoliative dermatitis
- fatigue
- flushing
- gingival hyperplasia
- gynecomastia
- headache
- heart failure
- hepatomegaly
- hypokalemia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- leukopenia
- maculopapular rash
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- orthostatic hypotension
- palpitations
- paresthesias
- peripheral edema
- peripheral vasodilation
- pharyngitis
- pruritus
- rash
- sinus tachycardia
- sinusitis
- skin discoloration
- skin irritation
- skin ulcer
- stroke
- supraventricular tachycardia (SVT)
- syncope
- tinnitus
- urticaria
- visual impairment
- xerosis
Monitoring Parameters
- blood pressure
- heart rate
Contraindications
- acute myocardial infarction
- aortic stenosis
- bradycardia
- breast-feeding
- cardiogenic shock
- children
- coronary artery disease
- dihydropyridine hypersensitivity
- gastroesophageal reflux disease (GERD)
- geriatric
- heart failure
- hepatic disease
- hiatal hernia
- hypotension
- pregnancy
- ventricular dysfunction
Interactions
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alfuzosin
- Alprostadil
- Amifostine
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzonatate
- Benzphetamine
- Betaxolol
- Bexarotene
- Bicalutamide
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Brigatinib
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Butabarbital
- Cabergoline
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clobazam
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Dalfopristin; Quinupristin
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- Darunavir
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- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dorzolamide; Timolol
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
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- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Encorafenib
- Enflurane
- Enzalutamide
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Ergonovine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esmolol
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Etomidate
- Etravirine
- Everolimus
- Famotidine; Ibuprofen
- Fedratinib
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Fostamatinib
- General anesthetics
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- grapefruit juice
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Indinavir
- Indomethacin
- Intravenous Lipid Emulsions
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Istradefylline
- Itraconazole
- Ivacaftor
- Ivosidenib
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lanreotide
- Lansoprazole; Naproxen
- Lapatinib
- Larotrectinib
- Lasmiditan
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levodopa
- Lisdexamfetamine
- Lithium
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorlatinib
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Meclofenamate Sodium
- Mefenamic Acid
- Melatonin
- Meloxicam
- Mephobarbital
- Mestranol; Norethindrone
- Methamphetamine
- Methohexital
- Methoxsalen
- Methylphenidate
- Methysergide
- Metoprolol
- Mifepristone
- Milrinone
- Mitotane
- Modafinil
- Nabumetone
- Nadolol
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nilotinib
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osilodrostat
- Oxaprozin
- Oxcarbazepine
- Oxymetazoline
- Palbociclib
- Paliperidone
- Pasireotide
- Pazopanib
- Penbutolol
- Pentobarbital
- Pentoxifylline
- Pexidartinib
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pindolol
- Piroxicam
- Posaconazole
- Prazosin
- Primidone
- Procainamide
- Procaine
- Propofol
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinidine
- Quinine
- Ranolazine
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rofecoxib
- Rucaparib
- Saquinavir
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selpercatinib
- Sevoflurane
- Silodosin
- Simeprevir
- Sincalide
- Sotalol
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sufentanil
- Sulindac
- Tamsulosin
- Tazemetostat
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiopental
- Thiothixene
- Ticagrelor
- Timolol
- Tipranavir
- Tolmetin
- Topiramate
- Tranylcypromine
- Trazodone
- Tucatinib
- Valdecoxib
- Vemurafenib
- Verteporfin
- Voriconazole
- Yohimbine
- Zafirlukast
- Zanubrutinib
- Ziprasidone
