Niraparib

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Niraparib Brand Name– ZEJULA

What is Niraparib

Niraparib is an oral poly (ADP-ribose) polymerase (PARP) inhibitor. PARP enzymes are involved in normal cellular homeostasis, including DNA transcription, cell cycle regulation, and DNA repair.

It is indicated as maintenance therapy in patients with platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancer, as well as monotherapy for patients with heavily pretreated, advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients with associated homologous recombination deficiency (HRD) positive status.

Niraparib has been associated with hematologic toxicity; cases of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) have also been reported. Complete blood counts should be closely monitored.

Indications

  • ovarian cancer

For the treatment of ovarian cancer

for the first-line maintenance therapy of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients who are in a complete or partial response to first-line platinum-based chemotherapy, as monotherapy

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. anaphylactoid reactions
  4. anemia
  5. anemia
  6. anorexia
  7. anorexia
  8. anxiety
  9. anxiety
  10. asthenia
  11. asthenia
  12. back pain
  13. back pain
  14. confusion
  15. conjunctivitis
  16. constipation
  17. constipation
  18. cough
  19. depression
  20. diarrhea
  21. diarrhea
  22. dizziness
  23. dysgeusia
  24. dyspepsia
  25. dyspnea
  26. dyspnea
  27. elevated hepatic enzymes
  28. elevated hepatic enzymes
  29. encephalopathy
  30. epistaxis
  31. fatigue
  32. fatigue
  33. GI obstruction
  34. GI perforation
  35. hallucinations
  36. headache
  37. headache
  38. hyperglycemia
  39. hyperglycemia
  40. hypertension
  41. hypertension
  42. hypertensive crisis
  43. hypoalbuminemia
  44. hypoalbuminemia
  45. hypokalemia
  46. hypomagnesemia
  47. hypomagnesemia
  48. hyponatremia
  49. hyponatremia
  50. impaired cognition
  51. infection
  52. infection
  53. insomnia
  54. insomnia
  55. leukemia
  56. leukopenia
  57. leukopenia
  58. lymphopenia
  59. musculoskeletal pain
  60. musculoskeletal pain
  61. nausea
  62. nausea
  63. neutropenia
  64. neutropenia
  65. new primary malignancy
  66. palpitations
  67. peripheral edema
  68. pharyngitis
  69. photosensitivity
  70. pleural effusion
  71. pneumonitis
  72. rash
  73. rash
  74. renal failure (unspecified)
  75. sinus tachycardia
  76. stomatitis
  77. stomatitis
  78. thrombocytopenia
  79. thrombocytopenia
  80. vomiting
  81. vomiting
  82. weight loss
  83. xerostomia
  84. xerostomia

Monitoring Parameters

  • blood pressure
  • CBC with differential
  • heart rate
  • pregnancy testing

Contraindications

  • anemia
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • contraception requirements
  • heart failure
  • hypertension
  • hypertensive crisis
  • infertility
  • leukemia
  • myelodysplastic syndrome (MDS)
  • neutropenia
  • new primary malignancy
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • thrombocytopenia

Interactions

There are no drug interactions associated with Niraparib products.

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What is recurrence

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