Neomycin and Polymyxin B Brand Name– Neosporin GU
What is Neomycin and Polymyxin B
Neomycin and Polymyxin B irrigant solution (Neosporin® GU) is a concentrated, sterile antibiotic solution that is diluted for continuous urinary bladder irrigation.
Each ml contains a combination of 40 mg of neomycin base and 200,000 units of polymyxin B sulfate.
Neomycin and Polymyxin B GU irrigant solution is indicated for short-term (i.e., up to 10 days) use in abacteriuric patients for the prevention of infections associated with the use of indwelling catheters.
Polymyxin B is a polypeptide antibiotic derived from Bacillus polymyxa. Neomycin, an aminoglycoside, is derived from cultures of Streptomyces fradiae.
Neosporin® GU irrigant solution was approved by the FDA prior to 1982.
Indications
- bacteremia prophylaxis
- Enterobacter sp.
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella sp.
- Neisseria sp.
- Pseudomonas aeruginosa
- Staphylococcus aureus (MSSA)
Side Effects
- candidiasis
- pruritus
- superinfection
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- aminoglycoside hypersensitivity
- botulism
- breast-feeding
- children
- colitis
- dehydration
- diarrhea
- geriatric
- GI disease
- hearing impairment
- infants
- inflammatory bowel disease
- myasthenia gravis
- neomycin hypersensitivity
- neonates
- neuromuscular disease
- parkinsonism
- polymyxin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal impairment
- respiratory insufficiency
- surgery
- ulcerative colitis
Interactions
There are no drug interactions associated with Neomycin and Polymyxin B products.
