Neomycin Polymyxin B Prednisolone

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Neomycin Polymyxin B Prednisolone Brand Name– Poly Pred

What is Neomycin Polymyxin B Prednisolone

Neomycin polymyxin B prednisolone are used together in an ophthalmic suspension to treat ocular inflammation where there is a risk of infection.

Neomycin is an aminoglycoside antibiotic derived from cultures of Streptomyces fradiae. Polymyxin B is a polypeptide antibiotic derived from a strain of Bacillus polymyxa.

Both of these antibiotics affect primarily gram-negative, aerobic bacteria, but are also effective against Staphylococcus aureus (methicillin-sensitive).

Prednisolone is a glucocorticoid antiinflammatory agent. Prolonged use of topical corticosteroids can lead to systemic absorption.

Poly-Pred® was approved by the FDA in May 1963.


  1. bacterial conjunctivitis
  2. Enterobacter sp.
  3. Escherichia coli
  4. Haemophilus influenzae (beta-lactamase negative)
  5. Haemophilus influenzae (beta-lactamase positive)
  6. Klebsiella sp.
  7. Neisseria sp.
  8. ocular inflammation
  9. ophthalmic infection
  10. Pseudomonas aeruginosa
  11. Staphylococcus aureus (MSSA)
  12. uveitis

Side Effects

  1. blurred vision
  2. cataracts
  3. erythema
  4. ocular hypertension
  5. ocular irritation
  6. ocular pruritus
  7. pruritus
  8. superinfection

Monitoring Parameters

  • laboratory monitoring not necessary


  • aminoglycoside hypersensitivity
  • breast-feeding
  • contact lenses
  • fungal infection
  • glaucoma
  • herpes infection
  • neomycin hypersensitivity
  • pregnancy
  • surgery
  • varicella
  • viral infection


There are no drug interactions associated with Neomycin Polymyxin B Prednisolone products.

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