Molindone Brand Name– Moban
What is Molindone
Molindone is an oral dihydroindolone (non-phenothiazine) antipsychotic agent used for the symptomatic management of schizophrenia.
Relative to other conventional antipsychotics, molindone has high extrapyramidal effects, low sedative effects, and low anticholinergic effects.
Molindone (Moban) was approved by the FDA in 1974.
Indications
- behavioral or psychological symptoms of dementia
- schizophrenia
For the treatment of schizophrenia
Side Effects
- agranulocytosis
- akathisia
- akinesia
- amenorrhea
- aplastic anemia
- blurred vision
- constipation
- depression
- drowsiness
- dysphagia
- dystonic reaction
- elevated hepatic enzymes
- eosinophilia
- euphoria
- fever
- galactorrhea
- gynecomastia
- hemolytic anemia
- hyperprolactinemia
- hypersalivation
- hyperthermia
- hyponatremia
- hypotension
- hypothermia
- leukocytosis
- leukopenia
- libido increase
- nausea
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- pancytopenia
- polydipsia
- priapism
- pseudoparkinsonism
- purpura
- rash
- seizures
- SIADH
- sinus tachycardia
- stroke
- syncope
- tardive dyskinesia
- thrombocytopenia
- tremor
- urinary retention
- water intoxication
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- AIMS assessment
Contraindications
- abrupt discontinuation
- agranulocytosis
- ambient temperature increase
- brain tumor
- breast cancer
- breast-feeding
- cardiac disease
- cerebrovascular disease
- chemotherapy
- children
- CNS depression
- coadministration with other CNS depressants
- coma
- dehydration
- dementia
- driving or operating machinery
- dysphagia
- ethanol ingestion
- geriatric
- GI obstruction
- hematological disease
- hyperprolactinemia
- hyperthermia
- hypotension
- hypothermia
- hypovolemia
- ileus
- infants
- infertility
- leukopenia
- neonates
- neurological disease
- neutropenia
- orthostatic hypotension
- Parkinson’s disease
- pregnancy
- pregnancy testing
- Reye’s syndrome
- seizure disorder
- seizures
- strenuous exercise
- stroke
- suicidal ideation
- sulfite hypersensitivity
- tardive dyskinesia
Interactions
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acetazolamide
- Aldesleukin, IL-2
- Alprazolam
- Amantadine
- Amifampridine
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anticholinergics
- Aripiprazole
- Asenapine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brexpiprazole
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butorphanol
- Cabergoline
- Cannabidiol
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Cariprazine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cetrorelix
- Chlordiazepoxide; Clidinium
- Chlorpromazine
- Chlorzoxazone
- Clobazam
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclobenzaprine
- Dantrolene
- Degarelix
- Demeclocycline
- Desipramine
- Deutetrabenazine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Promethazine
- Diazepam
- Dicyclomine
- dopamine agonists
- Doxepin
- Doxycycline
- Dronabinol
- Droperidol
- Entacapone
- Esketamine
- Eszopiclone
- Ethanol
- Ethosuximide
- Ethotoin
- Felbamate
- Fenfluramine
- Flavoxate
- Fluoxetine; Olanzapine
- Fluphenazine
- food
- Fosphenytoin
- Gabapentin
- Ganirelix
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Haloperidol
- Histrelin
- Homatropine; Hydrocodone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Iloperidone
- Imipramine
- Indacaterol; Glycopyrrolate
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Isosulfan Blue
- Lacosamide
- Lamotrigine
- Lasmiditan
- Leuprolide
- Leuprolide; Norethindrone
- Levetiracetam
- Levocetirizine
- Levodopa
- Lithium
- Lofexidine
- Lorazepam
- Loxapine
- Lumateperone
- Lurasidone
- Maprotiline
- Mepenzolate
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Mesoridazine
- Metaxalone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methscopolamine
- Methsuximide
- Methylphenidate
- Metoclopramide
- Metyrapone
- Metyrosine
- Minocycline
- Mirtazapine
- Nabilone
- Nafarelin
- Nalbuphine
- Non-Ionic Contrast Media
- Nortriptyline
- Olanzapine
- Omadacycline
- Opiate Agonists
- Orphenadrine
- Oxcarbazepine
- Oxybutynin
- Paliperidone
- Pemoline
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Pregabalin
- Primidone
- Prochlorperazine
- Promethazine
- Propantheline
- Protriptyline
- Quazepam
- Quetiapine
- Rasagiline
- Risperidone
- Rotigotine
- Rufinamide
- Safinamide
- Sarecycline
- Scopolamine
- Sedating H1-blockers
- Skeletal Muscle Relaxants
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Tapentadol
- Tetrabenazine
- Tetracycline
- Tetracyclines
- Thalidomide
- Thioridazine
- Thiothixene
- Tiagabine
- Tizanidine
- Tolcapone
- Topiramate
- Tramadol
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimipramine
- Triptorelin
- Valproic Acid, Divalproex Sodium
- Vigabatrin
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem
- Zonisamide
