Mogamulizumab

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Mogamulizumab Brand Name– POTELIGEO

What is Mogamulizumab

Mogamulizumab-kpkc is a CC chemokine receptor type 4 (CCR4)-directed monoclonal antibody indicated for the treatment of adult patients with relapsed or refractory mycosis fungoides or Sezary syndrome after at least 1 prior systemic therapy.

Fatal and life-threatening skin reactions and infusion-related reactions have been reported with mogamulizumab therapy.

Indications

  • cutaneous T-cell lymphoma (CTCL)
  • mycosis fungoides

For the treatment of cutaneous T-cell lymphoma (CTCL), specifically mycosis fungoides or sezary syndrome, in patients who have received at least 1 prior systemic therapy

NOTE: Mogamulizumab has been designated by the FDA as an orphan drug for the treatment of patients with CTCL.

Side Effects

  1. abdominal pain
  2. alopecia
  3. anemia
  4. anemia
  5. anorexia
  6. antibody formation
  7. atopic dermatitis
  8. atopic dermatitis
  9. back pain
  10. back pain
  11. bone pain
  12. bone pain
  13. bullous rash
  14. bullous rash
  15. candidiasis
  16. cardiomyopathy
  17. chills
  18. conjunctivitis
  19. constipation
  20. contact dermatitis
  21. contact dermatitis
  22. cough
  23. depression
  24. diarrhea
  25. dizziness
  26. dyspnea
  27. edema
  28. elevated hepatic enzymes
  29. elevated hepatic enzymes
  30. exfoliative dermatitis
  31. fatigue
  32. fever
  33. fever
  34. folliculitis
  35. graft-versus-host disease (GVHD)
  36. Guillain-Barre syndrome
  37. headache
  38. heart failure
  39. hepatitis
  40. hepatitis B exacerbation
  41. hypercalcemia
  42. hypercalcemia
  43. hyperglycemia
  44. hyperglycemia
  45. hypertension
  46. hyperuricemia
  47. hypoalbuminemia
  48. hypoalbuminemia
  49. hypocalcemia
  50. hypocalcemia
  51. hypoglycemia
  52. hypomagnesemia
  53. hypomagnesemia
  54. hypophosphatemia
  55. hypophosphatemia
  56. hypothyroidism
  57. infection
  58. infection
  59. infusion-related reactions
  60. infusion-related reactions
  61. insomnia
  62. laryngitis
  63. leukopenia
  64. lymphopenia
  65. lymphopenia
  66. maculopapular rash
  67. maculopapular rash
  68. muscle cramps
  69. musculoskeletal pain
  70. musculoskeletal pain
  71. myalgia
  72. myalgia
  73. myocardial infarction
  74. myocarditis
  75. nausea
  76. nephrotoxicity
  77. neutropenia
  78. neutropenia
  79. oral ulceration
  80. oral ulceration
  81. peripheral neuropathy
  82. pharyngitis
  83. pneumonitis
  84. psoriaform rash
  85. rash
  86. rash
  87. rhinitis
  88. sinus tachycardia
  89. sinusitis
  90. skin ulcer
  91. skin ulcer
  92. Stevens-Johnson syndrome
  93. stomatitis
  94. stomatitis
  95. thrombocytopenia
  96. toxic epidermal necrolysis
  97. tumor lysis syndrome (TLS)
  98. vomiting
  99. weight gain
  100. weight loss
  101. xerosis

Monitoring Parameters

  • pregnancy testing

Contraindications

  • allogeneic stem cell transplant
  • autoimmune disease
  • breast-feeding
  • contraception requirements
  • immune-mediated reactions
  • infection
  • infusion-related reactions
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • serious rash

Interactions

  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD

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