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What is Mezlocillin
NOTE: This drug is discontinued in the US.
Mezlocillin is a parenteral, semisynthetic, extended-spectrum acylureidopenicillin.
Clinically, mezlocillin is used in the treatment of intra-abdominal infections, respiratory and urinary tract infections, skin and soft-tissue infections, and other infections caused by susceptible bacteria.
Mezlocillin is often used in combination with an aminoglycoside to treat systemic Pseudomonas infections.
It is not effective against staphylococcus.
Mezlocillin was approved by the FDA in 1981.
Indications
- Acinetobacter sp.
- Actinomyces sp.
- Bacillus anthracis
- bacteremia
- Bacteroides fragilis
- Bacteroides sp.
- Bifidobacterium sp.
- bone and joint infections
- Brevundimonas vesicularis
- cellulitis
- cholangitis
- cholecystitis
- Citrobacter sp.
- Clostridium perfringens
- Clostridium sp.
- diabetic foot ulcer
- Eikenella corrodens
- endometritis
- Enterobacter sp.
- Enterococcus faecalis
- Escherichia coli
- Eubacterium sp.
- febrile neutropenia
- Flavobacterium sp.
- Fusobacterium sp.
- gonorrhea
- gynecologic infections
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus parainfluenzae
- hepatic abscess
- intraabdominal abscess
- intraabdominal infections
- Klebsiella pneumoniae
- Klebsiella sp.
- Lactobacillus sp.
- lower respiratory tract infections
- lung abscess
- meningitis
- Moraxella sp.
- Morganella morganii
- Neisseria meningitidis
- Pasteurella multocida
- pelvic cellulitis
- pelvic inflammatory disease (PID)
- Peptococcus sp.
- Peptostreptococcus sp.
- peritonitis
- pneumonia
- Propionibacterium sp.
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- Pseudomonas stutzeri
- Salmonella sp.
- Serratia sp.
- Shigella sp.
- skin and skin structure infections
- Streptococcus agalactiae (group B streptococci)
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- surgical infection prophylaxis
- urinary tract infection (UTI)
- Veillonella sp.
- Viridans streptococci
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- arthralgia
- bullous rash
- candidiasis
- chills
- diarrhea
- dysgeusia
- elevated hepatic enzymes
- eosinophilia
- erythema nodosum
- exfoliative dermatitis
- fever
- hypokalemia
- injection site reaction
- interstitial nephritis
- leukopenia
- maculopapular rash
- malaise
- myalgia
- nausea
- nephrotic syndrome
- neutropenia
- phlebitis
- platelet dysfunction
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- purpura
- renal tubular necrosis
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- thrombosis
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum potassium
Contraindications
- asthma
- biliary obstruction
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- colitis
- cystic fibrosis
- diabetes mellitus
- diarrhea
- eczema
- electrolyte imbalance
- GI disease
- hypokalemia
- penicillin hypersensitivity
- pregnancy
- renal disease
- renal failure
- renal impairment
- sexually transmitted disease
- sodium restriction
Interactions
No information is available regarding drug interactions associated with Mezlocillin
