Methylprednisolone

Methylprednisolone Brand Names

A-Methapred | Depmedalone-40 | Depmedalone-80 | Depo-Medrol | Medrol | Medrol Dosepak | Solu-Medrol

What is Methylprednisolone

Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used orally or parenterally as antiinflammatory or immunosuppressive agents.

Methylprednisolone is used in many conditions in adult and pediatric patients, including many allergic, dermatologic, and inflammatory states when systemic treatment is medically necessary.

The drug is commonly used parenterally when a patient cannot take oral prednisone.

Methylprednisolone has very little mineralocorticoid activity and is therefore not used to manage adrenal insufficiency unless a more potent mineralocorticoid is administered concomitantly.

Systemic corticosteroids may be added to other long-term maintenance medications in the management of uncontrolled severe persistent asthma.

Once stabilization of asthma is achieved, regular attempts should be made to reduce or eliminate the use of systemic corticosteroids due to the side effects associated with chronic administration.

Short courses of treatment may be used in moderate to severe exacerbations of asthma or COPD.

If long-term therapy is required, the lowest possible effective dose should be used.

Indications

  1. acute interstitial nephritis (AIN)
  2. acute lymphocytic leukemia (ALL)
  3. acute respiratory distress syndrome (ARDS)
  4. Addison’s disease
  5. adrenocortical insufficiency
  6. adrenogenital syndrome
  7. allergic conjunctivitis
  8. allergic rhinitis
  9. alopecia
  10. anaphylaxis
  11. angioedema
  12. ankylosing spondylitis
  13. anterior segment inflammation
  14. asthma
  15. atopic dermatitis
  16. berylliosis
  17. bursitis
  18. carpal tunnel syndrome
  19. chorioretinitis
  20. chronic lymphocytic leukemia (CLL)
  21. chronic obstructive pulmonary disease (COPD)
  22. Churg-Strauss syndrome
  23. congenital adrenal hyperplasia
  24. contact dermatitis
  25. corneal ulcer
  26. Crohn’s disease
  27. dermatitis herpetiformis
  28. dermatomyositis
  29. discoid lupus erythematosus
  30. eczema
  31. endophthalmitis
  32. eosinophilic pneumonia
  33. epicondylitis
  34. erythema multiforme
  35. erythroblastopenia
  36. exfoliative dermatitis
  37. fat embolism syndrome prophylaxis
  38. food allergy
  39. gouty arthritis
  40. graft-versus-host disease (GVHD)
  41. granuloma annulare
  42. Graves’ ophthalmopathy
  43. heart transplant rejection
  44. hemolytic anemia
  45. herpes zoster ocular infection
  46. Hodgkin lymphoma
  47. hypercalcemia
  48. hypoplastic anemia
  49. immune thrombocytopenic purpura (ITP)
  50. insect bites or stings
  51. iritis
  52. juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
  53. Kawasaki disease
  54. keloids
  55. keratitis
  56. kidney transplant rejection
  57. laryngotracheobronchitis (croup)
  58. lichen planus
  59. lichen simplex
  60. Loeffler’s syndrome
  61. lupus nephritis
  62. mixed connective tissue disease
  63. multiple myeloma
  64. multiple sclerosis
  65. multisystem inflammatory syndrome in children (MIS-C)
  66. myasthenia gravis
  67. mycosis fungoides
  68. necrobiosis lipoidica diabeticorum
  69. nephrotic syndrome
  70. non-Hodgkin’s lymphoma (NHL)
  71. optic neuritis
  72. osteoarthritis
  73. pemphigus
  74. perennial allergies
  75. Pneumocystis pneumonia (PCP)
  76. pneumonitis
  77. polyarteritis nodosa
  78. polychondritis
  79. polymyositis
  80. postoperative ocular inflammation
  81. proteinuria
  82. pruritus
  83. pseudogout
  84. psoriasis
  85. psoriatic arthritis
  86. pulmonary edema
  87. pulmonary fibrosis
  88. rheumatic carditis
  89. sarcoidosis
  90. seasonal allergies
  91. seborrheic dermatitis
  92. serum sickness
  93. severe acute respiratory syndrome (SARS)
  94. spinal cord injury
  95. status asthmaticus
  96. Stevens-Johnson syndrome
  97. systemic lupus erythematosus (SLE)
  98. temporal arteritis
  99. tenosynovitis
  100. thrombocytopenia
  101. thyroiditis
  102. trichinosis
  103. tuberculosis infection
  104. ulcerative colitis
  105. urticaria
  106. uveitis
  107. vernal keratoconjunctivitis
  108. Wegener’s granulomatosis

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. adrenocortical insufficiency
  4. alopecia
  5. amenorrhea
  6. anaphylactoid reactions
  7. angioedema
  8. anorexia
  9. anxiety
  10. appetite stimulation
  11. arrhythmia exacerbation
  12. arthralgia
  13. arthropathy
  14. avascular necrosis
  15. bone fractures
  16. bradycardia
  17. cardiac arrest
  18. cardiomyopathy
  19. cataracts
  20. constipation
  21. Cushing’s syndrome
  22. depression
  23. diabetes mellitus
  24. diaphoresis
  25. diarrhea
  26. dysmenorrhea
  27. ecchymosis
  28. edema
  29. EEG changes
  30. elevated hepatic enzymes
  31. emotional lability
  32. erythema
  33. esophageal ulceration
  34. euphoria
  35. exfoliative dermatitis
  36. exophthalmos
  37. fever
  38. fluid retention
  39. gastritis
  40. GI perforation
  41. glycosuria
  42. growth inhibition
  43. headache
  44. heart failure
  45. hepatitis
  46. hepatomegaly
  47. hiccups
  48. hirsutism
  49. hypercholesterolemia
  50. hyperglycemia
  51. hypernatremia
  52. hypertension
  53. hypertrichosis
  54. hypocalcemia
  55. hypokalemia
  56. hypotension
  57. hypothalamic-pituitary-adrenal (HPA) suppression
  58. immunosuppression
  59. impaired wound healing
  60. increased intracranial pressure
  61. infection
  62. injection site reaction
  63. insomnia
  64. lactose intolerance
  65. lethargy
  66. leukocytosis
  67. malaise
  68. menstrual irregularity
  69. metabolic alkalosis
  70. myalgia
  71. myopathy
  72. nausea
  73. neuritis
  74. ocular hypertension
  75. ocular infection
  76. optic neuritis
  77. osteoporosis
  78. palpitations
  79. pancreatitis
  80. papilledema
  81. paresthesias
  82. peptic ulcer
  83. peripheral neuropathy
  84. petechiae
  85. phlebitis
  86. physiological dependence
  87. pseudotumor cerebri
  88. psychosis
  89. pulmonary edema
  90. rash
  91. restlessness
  92. retinopathy
  93. scleroderma renal crisis
  94. seizures
  95. sinus tachycardia
  96. skin atrophy
  97. skin hyperpigmentation
  98. skin hypopigmentation
  99. sodium retention
  100. striae
  101. syncope
  102. tendon rupture
  103. thromboembolism
  104. thrombosis
  105. urinary incontinence
  106. urinary urgency
  107. urticaria
  108. vasculitis
  109. vertigo
  110. visual impairment
  111. vomiting
  112. weakness
  113. weight gain
  114. withdrawal
  115. xerosis

Monitoring Parameters

  • blood glucose
  • blood pressure
  • growth rate
  • pulmonary function tests (PFTs)
  • serum potassium
  • weight

Contraindications

  • abrupt discontinuation
  • breast-feeding
  • cataracts
  • children
  • coagulopathy
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • diverticulitis
  • epidural administration
  • fungal infection
  • geriatric
  • GI perforation
  • glaucoma
  • growth inhibition
  • head trauma
  • heart failure
  • hepatic disease
  • herpes infection
  • hypertension
  • hyperthyroidism
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • hypothyroidism
  • immune thrombocytopenic purpura (ITP)
  • immunosuppression
  • increased intracranial pressure
  • increased intraocular pressure
  • infants
  • infection
  • intrathecal administration
  • intravenous administration
  • measles
  • myasthenia gravis
  • mycobacterial infection
  • myocardial infarction
  • neonates
  • neurologic events
  • osteoporosis
  • peptic ulcer disease
  • pregnancy
  • premature neonates
  • psychosis
  • renal disease
  • scleroderma
  • seizure disorder
  • sepsis
  • surgery
  • thromboembolic disease
  • thyroid disease
  • tuberculosis
  • ulcerative colitis
  • vaccination
  • varicella
  • viral infection
  • visual disturbance

Interactions

  • Abatacept
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetazolamide
  • Acetohexamide
  • Adalimumab
  • Albiglutide
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Altretamine
  • Ambenonium Chloride
  • Amifampridine
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amiodarone
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Aprepitant, Fosaprepitant
  • Argatroban
  • Arsenic Trioxide
  • Asparaginase Erwinia chrysanthemi
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azathioprine
  • Azilsartan; Chlorthalidone
  • Basiliximab
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bepridil
  • Bexarotene
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bivalirudin
  • Boceprevir
  • Bortezomib
  • Bosentan
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Bupropion
  • Bupropion; Naltrexone
  • Butabarbital
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Phenylephrine
  • Carmustine, BCNU
  • Ceritinib
  • Certolizumab pegol
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chlorambucil
  • Chlorothiazide
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Cimetidine
  • Cisatracurium
  • Citalopram
  • Clarithromycin
  • Clindamycin
  • Clofarabine
  • Cobicistat
  • Codeine; Phenylephrine; Promethazine
  • Conivaptan
  • Cyclosporine
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Denileukin Diftitox
  • Denosumab
  • Desmopressin
  • Dextran
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Digoxin
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dofetilide
  • Doxacurium
  • Dronedarone
  • Droperidol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dulaglutide
  • Echinacea
  • Econazole
  • Efalizumab
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Erlotinib
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Estramustine
  • Estrogens
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Etravirine
  • Exenatide
  • Fluconazole
  • Fluoxymesterone
  • Fosamprenavir
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gallium Ga 68 Dotatate
  • Gemcitabine
  • Gentamicin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycerol Phenylbutyrate
  • Golimumab
  • grapefruit juice
  • Guaifenesin; Phenylephrine
  • Halofantrine
  • Haloperidol
  • Hemin
  • Heparin
  • Hetastarch
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Phenylephrine
  • Hydroxyurea
  • Hylan G-F 20
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Idelalisib
  • Incretin Mimetics
  • Indapamide
  • Inebilizumab
  • Infliximab
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Iohexol
  • Iopamidol
  • Isavuconazonium
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Isotretinoin
  • Itraconazole
  • Ketoconazole
  • L-Asparaginase Escherichia coli
  • Letermovir
  • Levetiracetam
  • Levomefolate
  • Levomethadyl
  • Linagliptin; Metformin
  • Liraglutide
  • Live Vaccines
  • Lixisenatide
  • Lomustine, CCNU
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Macimorelin
  • Magnesium Salicylate
  • Mannitol
  • Mecasermin rinfabate
  • Mecasermin, Recombinant, rh-IGF-1
  • Meglitinides
  • Melphalan
  • Mepenzolate
  • Mephobarbital
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methacholine
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methoxsalen
  • Methyclothiazide
  • Metolazone
  • Metyrapone
  • Micafungin
  • Mifepristone
  • Mitotane
  • Mitoxantrone
  • Mivacurium
  • Moxifloxacin
  • Muromonab-CD3
  • Natalizumab
  • Nateglinide
  • Nefazodone
  • Nelarabine
  • Neostigmine
  • Neuromuscular blockers
  • Nicardipine
  • Nonsteroidal antiinflammatory drugs
  • Ocrelizumab
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Oxymetholone
  • Ozanimod
  • Pancuronium
  • Pazopanib
  • Pegaspargase
  • Peginterferon Alfa-2a
  • Penicillamine
  • Phenobarbital
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Physostigmine
  • Pimozide
  • Posaconazole
  • Potassium
  • Potassium Chloride
  • Potassium Phosphate; Sodium Phosphate
  • Potassium-sparing diuretics
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Primidone
  • Propranolol
  • Propylthiouracil, PTU
  • Purine analogs
  • Pyridostigmine
  • Quetiapine
  • Quinolones
  • Rapacuronium
  • Regular Insulin
  • Repaglinide
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Rilonacept
  • Ritodrine
  • Ritonavir
  • Rituximab
  • Rituximab; Hyaluronidase
  • Rocuronium
  • Salicylates
  • Salsalate
  • Saquinavir
  • Sargramostim, GM-CSF
  • Semaglutide
  • SGLT2 Inhibitors
  • Siponimod
  • Sipuleucel-T
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium Chloride
  • Sodium Phenylbutyrate
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Somatropin, rh-GH
  • Succinylcholine
  • Sulfonylureas
  • Tacrolimus
  • Telaprevir
  • Telbivudine
  • Telithromycin
  • Telotristat Ethyl
  • Testosterone
  • Thiazide diuretics
  • Thiazolidinediones
  • Thyroid hormones
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tositumomab
  • Trandolapril; Verapamil
  • Tranexamic Acid
  • Tretinoin, ATRA
  • Tuberculin Purified Protein Derivative, PPD
  • Tubocurarine
  • Tucatinib
  • Vancomycin
  • Vecuronium
  • Verapamil
  • Vigabatrin
  • Vincristine Liposomal
  • Voriconazole
  • Vorinostat
  • Warfarin
  • Zafirlukast
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