Methyltestosterone

Methyltestosterone Brand Names

Android | Methitest | Testred | Virilon

What is Methyltestosterone

Methyltestosterone was developed synthetically in the search for an androgen that could be given orally, without loss of bioavailability.

Mehyltestosterone is structurally similar to testosterone, except it is methylated at 17 position, which is associated with less hepatic metabolism following oral administration when compared to testosterone.

Methyltestosterone is used in the management of congenital or acquired hypogonadism.

Methyltestosterone may be considered appropriate therapy for pathological, delayed puberty, and it is effective as palliative treatment for carcinoma of the breast in postmenopausal women, acting as an antiestrogen.

Anabolic steroids have been the subject of drug misuse and abuse, often producing adverse effects such as changes in libido, hepatotoxicity, increased risk of cardiovascular disease, and antisocial behavior.

Some of the masculinizing effects in women can be irreversible.

Methyltestosterone was first approved as a topical ointment (which has been withdrawn from the market) by the FDA in 1939.

Oral forms became available beginning in 1940 and became a controlled substance in 1991.

Indications

  1. andropause
  2. cryptorchidism
  3. delayed puberty
  4. erectile dysfunction (ED)
  5. hypogonadism
  6. palliative treatment of breast cancer

For androgen replacement therapy, including symptoms consistent with andropause, erectile dysfunction (ED), or hypogonadism

Side Effects

  1. acne vulgaris
  2. alopecia
  3. amenorrhea
  4. anaphylactoid reactions
  5. anxiety
  6. bleeding
  7. clitoromegaly
  8. depression
  9. dysphonia
  10. elevated hepatic enzymes
  11. epididymitis
  12. epiphyseal closure
  13. erythrocytosis
  14. feminization
  15. fluid retention
  16. gynecomastia
  17. headache
  18. hepatitis
  19. hirsutism
  20. hypercalcemia
  21. hypercholesterolemia
  22. jaundice
  23. libido decrease
  24. libido increase
  25. nausea
  26. new primary malignancy
  27. oligomenorrhea
  28. paresthesias
  29. peliosis hepatis
  30. peripheral edema
  31. polycythemia
  32. priapism
  33. prostatic hypertrophy
  34. pulmonary embolism
  35. thromboembolism
  36. thrombosis
  37. virilization
  38. vomiting
  39. weight gain

Monitoring Parameters

  • LFTs

Contraindications

  • breast cancer
  • breast-feeding
  • cardiac disease
  • children
  • coronary artery disease
  • diabetes mellitus
  • geriatric
  • heart failure
  • hepatic disease
  • hypercalcemia
  • myocardial infarction
  • pregnancy
  • prostate cancer
  • prostatic hypertrophy
  • renal disease

Interactions

  • Abarelix
  • Acarbose
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Anticoagulants
  • Antithrombin III
  • Apixaban
  • Argatroban
  • Betrixaban
  • Bivalirudin
  • Canagliflozin
  • Canagliflozin; Metformin
  • Cyclosporine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darbepoetin Alfa
  • Degarelix
  • Desirudin
  • Dipeptidyl Peptidase-4 Inhibitors
  • Edoxaban
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enoxaparin
  • Epoetin Alfa
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Fondaparinux
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Goserelin
  • Heparin
  • Histrelin
  • Imipramine
  • Incretin Mimetics
  • Insulins
  • Lepirudin
  • Leuprolide
  • Leuprolide; Norethindrone
  • Linagliptin
  • Linagliptin; Metformin
  • Meglitinides
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methotrexate
  • Methoxy polyethylene glycol-epoetin beta
  • Miglitol
  • Nafarelin
  • Pentosan
  • Pramlintide
  • Rivaroxaban
  • Saw Palmetto, Serenoa repens
  • Saxagliptin
  • SGLT2 Inhibitors
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sulfonylureas
  • Thiazolidinediones
  • Tinzaparin
  • Triptorelin
  • Warfarin