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Methscopolamine Brand Names- Pamine | Pamine Forte
What is Methscopolamine
Methscopolamine is an oral muscarinic-receptor antagonist structurally similar to scopolamine.
Historically, methscopolamine and other similar anticholinergics were often used, along with antacids, to decrease gastric acid secretion in patients with peptic ulcer disease.
More effective agents are currently available (H2-receptor blockers, proton-pump inhibitors) to manage peptic ulcer disease, including the use of antimicrobials and gastric acid suppression to eradicate Helicobacter pylori.
Although methscopolamine is FDA-approved as adjunctive therapy in the management of peptic ulcer disease, its efficacy in healing peptic ulcers, decreasing recurrence rate, or preventing complications has never been demonstrated.
Currently, methscopolamine has limited use in the treatment of peptic ulcer disease. Due to its anticholinergic effects on bronchial receptors, methscopolamine is also an ingredient in some combination products for the temporary relief of symptoms of allergic rhinitis, sinusitis, and the common cold.
Methscopolamine was approved by the FDA in 1952.
A lactose-free formulation of Pamine® was approved during June, 2001.
Indications
- duodenal ulcer
- gastric ulcer
For use as adjunctive therapy in the treatment of duodenal ulcer or gastric ulcer
Side Effects
- anaphylactic shock
- anaphylactoid reactions
- anhidrosis
- blurred vision
- confusion
- constipation
- cycloplegia
- dizziness
- drowsiness
- fever
- headache
- hyperthermia
- impotence (erectile dysfunction)
- insomnia
- lactation suppression
- mydriasis
- nausea
- ocular hypertension
- palpitations
- sinus tachycardia
- urinary retention
- urticaria
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticholinergic medications
- autonomic neuropathy
- bladder obstruction
- breast-feeding
- bromide hypersensitivity
- cardiac arrhythmias
- cardiac disease
- children
- chronic obstructive pulmonary disease (COPD)
- contact lenses
- coronary artery disease
- dehydration
- dementia
- driving or operating machinery
- esophagitis
- ethanol intoxication
- gastroesophageal reflux disease (GERD)
- geriatric
- GI obstruction
- glaucoma
- heart failure
- hemorrhagic shock
- hepatic disease
- hiatal hernia
- hypertension
- hyperthyroidism
- ileus
- infants
- myasthenia gravis
- neonates
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- pyloric stenosis
- renal disease
- sunlight (UV) exposure
- tachycardia
- toxic megacolon
- ulcerative colitis
- urinary retention
- urinary tract obstruction
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Aclidinium
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albuterol; Ipratropium
- Alfentanil
- Alosetron
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amantadine
- Ambenonium Chloride
- Amobarbital
- Amoxapine
- Antacids
- Anxiolytics; Sedatives; and Hypnotics
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Atomoxetine
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Botulinum Toxins
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carisoprodol
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cholinergic agonists
- Cisapride
- Clemastine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dantrolene
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Edrophonium
- Eluxadoline
- Erythromycin
- Erythromycin; Sulfisoxazole
- Ethanol
- Ezogabine
- Fentanyl
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone; Umeclidinium; Vilanterol
- Galantamine
- Glucagon
- Glycopyrronium
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Ipratropium
- Itraconazole
- Levocetirizine
- Levodopa
- Levorphanol
- Linaclotide
- Loperamide
- Loperamide; Simethicone
- Loxapine
- Lubiprostone
- Lurasidone
- Macimorelin
- Magnesium Hydroxide
- Maprotiline
- Meclizine
- Memantine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Metaxalone
- Methacholine
- Methadone
- Methocarbamol
- Methohexital
- Metoclopramide
- Mirtazapine
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nitrofurantoin
- Olanzapine
- Omeprazole; Sodium Bicarbonate
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Potassium
- Pramlintide
- Primidone
- Procainamide
- Prochlorperazine
- Promethazine
- Proton pump inhibitors
- Pyridostigmine
- Quetiapine
- Quinidine
- Rasagiline
- Remifentanil
- Revefenacin
- Rivastigmine
- Secobarbital
- Secretin
- Sedating H1-blockers
- Sincalide
- Sodium Bicarbonate
- Solifenacin
- Sufentanil
- Tacrine
- Tapentadol
- Tegaserod
- Thiazide diuretics
- Thiopental
- Thioridazine
- Thiothixene
- Tiotropium
- Tiotropium; Olodaterol
- Tizanidine
- Tolterodine
- Topiramate
- Tramadol
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Triprolidine
- Trospium
- Umeclidinium
- Umeclidinium; Vilanterol
- Zonisamide
