Methocarbamol Brand Name– Robaxin
What is Methocarbamol
Methocarbamol is an oral and parenteral, central nervous system depressant with sedative and musculoskeletal relaxant properties.
Methocarbamol is used as adjunct therapy for acute, painful musculoskeletal conditions and in the management of tetanus; it is not indicated for spasticity.
This drug was first marketed in the U.S. in 1957. Despite decades of use, there are little published data of sufficient quality to demonstrate efficacy of methocarbamol vs. placebo or comparator drugs for musculoskeletal conditions.
Indications
- musculoskeletal pain
- tetanus
For use as an adjunct to rest, physical therapy, and other measures for the relief of musculoskeletal pain associated with acute, painful musculoskeletal conditions
Side Effects
- amnesia
- anaphylactoid reactions
- angioedema
- blurred vision
- bradycardia
- confusion
- conjunctivitis
- diplopia
- dizziness
- drowsiness
- dyspepsia
- fever
- flushing
- headache
- hemolysis
- hypotension
- injection site reaction
- insomnia
- jaundice
- leukopenia
- metallic taste
- nasal congestion
- nausea
- nystagmus
- phlebitis
- pruritus
- rash
- seizures
- syncope
- urine discoloration
- urticaria
- vertigo
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- children
- coadministration with other CNS depressants
- driving or operating machinery
- ethanol ingestion
- extravasation
- geriatric
- hepatic disease
- history of angioedema
- hypotension
- infants
- laboratory test interference
- neonates
- pregnancy
- renal disease
- renal failure
- renal impairment
- seizure disorder
Methocarbamol is contraindicated for use by patients hypersensitive to methocarbamol or to any component of the formulation, such as a history of angioedema or anaphylactic reaction to methocarbamol.
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Alfentanil
- Alprazolam
- Ambenonium Chloride
- Amitriptyline; Chlordiazepoxide
- Amobarbital
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Butabarbital
- Butorphanol
- Cannabidiol
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cenobamate
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Cholinesterase inhibitors
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Deutetrabenazine
- Dexmedetomidine
- Dextromethorphan; Promethazine
- Diazepam
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Donepezil
- Donepezil; Memantine
- Dronabinol
- Droperidol
- Edrophonium
- Esketamine
- Estazolam
- Ethanol
- Fenfluramine
- Fentanyl
- Fluphenazine
- Flurazepam
- Gabapentin
- Galantamine
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibuprofen; Oxycodone
- Ketamine
- Lasmiditan
- Lemborexant
- Levorphanol
- Lofexidine
- Lorazepam
- Lumateperone
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mesoridazine
- Methadone
- Methohexital
- Methscopolamine
- Metyrapone
- Midazolam
- Molindone
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Neostigmine
- Oxazepam
- Oxycodone
- Oxymorphone
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Physostigmine
- Pregabalin
- Primidone
- Prochlorperazine
- Promethazine
- Pyridostigmine
- Quazepam
- Remifentanil
- Rivastigmine
- Secobarbital
- Sedating H1-blockers
- Sufentanil
- Tacrine
- Tapentadol
- Temazepam
- Thalidomide
- Thiethylperazine
- Thiopental
- Thioridazine
- Tramadol
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Ziconotide
- Ziprasidone
