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Methenamine Sodium Acid Phosphate Methylene Blue Hyoscyamine Brand Names
Indiomin MB | Urogesic Blue | Urolet | UTA
What is Methenamine Sodium Acid Phosphate Methylene Blue Hyoscyamine
Methenamine Sodium Acid Phosphate Methylene Blue Hyoscyamine are used together in an oral preparation for suppression of the symptoms of irritative voiding, such as hypermotility and spasticity, that are associated with lower urinary tract infections or which are caused by diagnostic procedures.
Methenamine is an antiinfective agent, providing local bacteriostatic or bacteriocidal actions.
Sodium acid phosphate is used to acidify the urine. An acidic urine is required to hydrolyze methenamine to ammonia and formaldehyde, which produces the bactericidal activity.
Hyoscyamine produces an antispasmodic effect, and methylene blue possesses weak antiseptic activity.
These combination products have been available on the market since before 1962, which is when Congress passed the amended Federal Food, Drug, and Cosmetic Act requiring that the FDA establish both safety and efficacy for all subsequently approved drugs.
Thus, these products are unapproved marketed drugs that have not been formally evaluated by the FDA for clinical safety and efficacy.
Indications
- urinary acidification
- urinary tract infection (UTI)
For the relief of discomfort associated with lower urinary tract infection (UTI) or diagnostic procedures by producing urinary acidification, reducing bacteriuria, and reducing spasmodic activity
Side Effects
- agitation
- anaphylactoid reactions
- angioedema
- blurred vision
- confusion
- constipation
- dizziness
- drowsiness
- dyspnea
- flushing
- nausea
- pruritus
- rash
- sinus tachycardia
- stool discoloration
- urinary retention
- urine discoloration
- vomiting
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
- urinalysis
Contraindications
- anuria
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- children
- coronary artery disease
- dehydration
- eclampsia
- edema
- formaldehyde hypersensitivity
- geriatric
- GI obstruction
- glaucoma
- heart failure
- hepatic disease
- hypernatremia
- hyperphosphatemia
- hypertension
- ileus
- infants
- mitral stenosis
- myasthenia gravis
- neonates
- oliguria
- pregnancy
- prostatic hypertrophy
- renal failure
- renal impairment
- sodium restriction
- urinary retention
- urinary tract obstruction
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acetazolamide
- Aclidinium
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albuterol; Ipratropium
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Alosetron
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amantadine
- Ambenonium Chloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphetamines
- Antacids
- Ascorbic Acid, Vitamin C
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzphetamine
- Betamethasone
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Botulinum Toxins
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorcyclizine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cholinergic agonists
- Ciclesonide
- Cisapride
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Clemastine
- Clomipramine
- Clozapine
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Corticosteroids
- Cortisone
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Deflazacort
- Desipramine
- Desvenlafaxine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazoxide
- Dichlorphenamide
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dolasetron
- Donepezil
- Donepezil; Memantine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Duloxetine
- Edrophonium
- Eluxadoline
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Erdafitinib
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Ezogabine
- Fenfluramine
- Fentanyl
- Fludrocortisone
- Flunisolide
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Galantamine
- Glucagon
- Glycopyrronium
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Hydroxyzine
- Ibuprofen; Oxycodone
- Imipramine
- Ipratropium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Lasmiditan
- Levocetirizine
- Levodopa
- Levomilnacipran
- Levorphanol
- Linaclotide
- Linezolid
- Lisdexamfetamine
- Lithium
- Loperamide
- Loperamide; Simethicone
- Lorcaserin
- Loxapine
- Lubiprostone
- Lurasidone
- Macimorelin
- Magnesium Hydroxide
- Magnesium Salicylate
- Maprotiline
- Meclizine
- Memantine
- Meperidine
- Meperidine; Promethazine
- Methacholine
- Methadone
- Methamphetamine
- Methazolamide
- Methoxsalen
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methylphenidate
- Methylprednisolone
- Methysergide
- Metoclopramide
- Metolazone
- Milnacipran
- Mirtazapine
- Molindone
- Mometasone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Neostigmine
- Netupitant, Fosnetupitant; Palonosetron
- Nitrofurantoin
- Nortriptyline
- Olanzapine
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Orphenadrine
- Oxycodone
- Oxymorphone
- Ozanimod
- Palonosetron
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Pergolide
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Physostigmine
- Porfimer
- Potassium
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Pramlintide
- Prednisolone
- Prednisone
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Proton pump inhibitors
- Protriptyline
- Pyridostigmine
- Pyrimethamine; Sulfadoxine
- Quetiapine
- Quinidine
- Rasagiline
- Remifentanil
- Revefenacin
- Rivastigmine
- Safinamide
- Salsalate
- Secretin
- Sedating H1-blockers
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Sertraline
- Sibutramine
- Sincalide
- Sodium Bicarbonate
- Solifenacin
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Tacrine
- Tapentadol
- Tegaserod
- Thiazide diuretics
- Thioridazine
- Thiothixene
- Tiotropium
- Tiotropium; Olodaterol
- Tolterodine
- Topiramate
- Tramadol
- Tranylcypromine
- Trazodone
- Triamcinolone
- Tricyclic antidepressants
- Trientine
- Trifluoperazine
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Trospium
- Umeclidinium
- Umeclidinium; Vilanterol
- Venlafaxine
- Verteporfin
- Vilazodone
- Vortioxetine
- Zonisamide
