Methamphetamine

Methamphetamine Brand Name– Desoxyn

What is Methamphetamine

Methamphetamine is an oral, centrally-acting stimulant used to treat attention-deficit hyperactivity disorder (ADHD) and for the short-term treatment (i.e., a few weeks) of exogenous obesity in conjunction with lifestyle modifications.

However, treatment guidelines do not support the use of methamphetamine for ADHD.

Other stimulants, such as amphetamine and methylphenidate, are highly effective in the treatment of ADHD and are considered first-line therapies.

According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines and other guidelines for obesity, short-term pharmacotherapy, such as with the amphetamine anorectics, has not been shown to produce longer-term health benefits in obese and overweight patients and cannot be generally recommended.

Amphetamines should not be used for long-term weight management; tolerance to the anorectic effect usually develops within a few weeks.

The most common adverse effects associated with use of amphetamines include anorexia, abdominal pain, irritability, restlessness, insomnia, emotional lability, and tachycardia.

Stimulants can induce or exacerbate psychiatric symptoms and close monitoring is recommended in patients with pre-existing psychosis or bipolar disorder. Amphetamines have a high potential for abuse and addiction and are contraindicated in patients with a history of substance abuse.

Stimulants have also been associated with sudden death in patients with structural cardiac abnormalities; patients with structural heart defects, cardiomyopathy, or heart-rhythm disturbances may be at risk for adverse cardiac events.

Methamphetamine was approved by the FDA in 1943.

Indications

  • attention-deficit hyperactivity disorder (ADHD)
  • narcolepsy
  • obesity

For treatment of attention-deficit hyperactivity disorder (ADHD) characterized by moderate to severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity

Side Effects

  1. abdominal pain
  2. agitation
  3. alopecia
  4. anaphylactoid reactions
  5. angina
  6. angioedema
  7. anorexia
  8. anxiety
  9. blurred vision
  10. cardiac arrest
  11. chest pain (unspecified)
  12. coma
  13. constipation
  14. delirium
  15. diaphoresis
  16. diarrhea
  17. dizziness
  18. dysgeusia
  19. dysphoria
  20. euphoria
  21. flushing
  22. growth inhibition
  23. hallucinations
  24. headache
  25. hyperhidrosis
  26. hypertension
  27. hyperthermia
  28. impotence (erectile dysfunction)
  29. insomnia
  30. irritability
  31. libido decrease
  32. libido increase
  33. mania
  34. mydriasis
  35. myocardial infarction
  36. nausea
  37. ocular hypertension
  38. palpitations
  39. paranoia
  40. peripheral vasoconstriction
  41. photosensitivity
  42. physiological dependence
  43. priapism
  44. psychological dependence
  45. psychosis
  46. rash
  47. respiratory arrest
  48. restlessness
  49. rhabdomyolysis
  50. seizures
  51. serotonin syndrome
  52. sinus tachycardia
  53. skin ulcer
  54. Stevens-Johnson syndrome
  55. stroke
  56. syncope
  57. tachypnea
  58. tolerance
  59. Tourette’s syndrome
  60. toxic epidermal necrolysis
  61. tremor
  62. urticaria
  63. vomiting
  64. weight loss
  65. withdrawal
  66. xerostomia

Monitoring Parameters

  • blood pressure
  • growth rate
  • heart rate
  • weight

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • alcoholism
  • anorexia nervosa
  • aortic stenosis
  • arteriosclerosis
  • bipolar disorder
  • breast-feeding
  • bulimia nervosa
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • congenital heart disease
  • coronary artery disease
  • depression
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • glaucoma
  • growth inhibition
  • heart failure
  • hypercortisolism
  • hypertension
  • hyperthyroidism
  • infants
  • lactase deficiency
  • mania
  • MAOI therapy
  • myocardial infarction
  • neonates
  • obesity treatment
  • peripheral vascular disease
  • pregnancy
  • prosthetic heart valves
  • psychosis
  • radiographic contrast administration
  • Raynaud’s phenomenon
  • schizophrenia
  • seizure disorder
  • seizures
  • stroke
  • substance abuse
  • suicidal ideation
  • surgery
  • tachycardia
  • thyrotoxicosis
  • tics
  • Tourette’s syndrome
  • valvular heart disease
  • ventricular arrhythmias
  • ventricular dysfunction
  • visual disturbance

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alkalinizing Agents
  • Almotriptan
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Ambrisentan
  • Amifampridine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Ammonium Chloride
  • Amoxapine
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Antacids
  • Arformoterol
  • Armodafinil
  • Ascorbic Acid, Vitamin C
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Beta-blockers
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Dextromethorphan; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide; Formoterol
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorcyclizine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cinacalcet
  • Citalopram
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Citric Acid; Sodium Citrate
  • Clemastine
  • Clevidipine
  • Clobazam
  • Clonidine
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • Cyclizine
  • Cyproheptadine
  • Dacomitinib
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desvenlafaxine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Quinidine
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Dulaglutide
  • Duloxetine
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Eletriptan
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Escitalopram
  • Esketamine
  • Eslicarbazepine
  • Esmolol
  • Ethacrynic Acid
  • Etomidate
  • Exenatide
  • Ezogabine
  • Felodipine
  • Fenfluramine
  • Fentanyl
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • food
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Frovatriptan
  • Furosemide
  • Gabapentin
  • General anesthetics
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Halothane
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibritumomab Tiuxetan
  • Ibuprofen; Oxycodone
  • Iloprost
  • Imatinib
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Irbesartan
  • Isocarboxazid
  • Isoflurane
  • Isosulfan Blue
  • Isradipine
  • Ketamine
  • Labetalol
  • Lacosamide
  • Lamotrigine
  • Lasmiditan
  • Levalbuterol
  • Levetiracetam
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Levomilnacipran
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lisinopril
  • Lithium
  • Lixisenatide
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Lorcaserin
  • Losartan
  • Loxapine
  • Lurasidone
  • Macitentan
  • Magnesium Hydroxide
  • Maprotiline
  • Mecamylamine
  • Meclizine
  • Meglitinides
  • Meperidine
  • Meperidine; Promethazine
  • Metaproterenol
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methazolamide
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylergonovine
  • Methysergide
  • Metolazone
  • Metoprolol
  • Miglitol
  • Milnacipran
  • Mirtazapine
  • Modafinil
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nalbuphine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Non-Ionic Contrast Media
  • Olmesartan
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Sodium Bicarbonate
  • Oritavancin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paroxetine
  • Peginterferon Alfa-2b
  • Penbutolol
  • Perampanel
  • Pergolide
  • Perindopril
  • Perindopril; Amlodipine
  • Phenelzine
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium-sparing diuretics
  • Pramlintide
  • Prazosin
  • Pregabalin
  • Procarbazine
  • Propafenone
  • Propofol
  • Propoxyphene
  • Propranolol
  • Quinapril
  • Quinidine
  • Quinine
  • Racepinephrine
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Riociguat
  • Ritonavir
  • Rizatriptan
  • Rosiglitazone
  • Rufinamide
  • Sacubitril; Valsartan
  • Safinamide
  • Salmeterol
  • Sedating H1-blockers
  • Selegiline
  • Selexipag
  • Semaglutide
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sodium Bicarbonate
  • Sodium Lactate
  • Sodium Oxybate
  • Solriamfetol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Tapentadol
  • Tedizolid
  • Telmisartan
  • Terazosin
  • Terbinafine
  • Terbutaline
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiothixene
  • Thyroid hormones
  • Tiagabine
  • Timolol
  • Tipranavir
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triamterene
  • Tricyclic antidepressants
  • Triprolidine
  • Tromethamine
  • Umeclidinium; Vilanterol
  • Valproic Acid, Divalproex Sodium
  • Valsartan
  • Vasodilators
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Vortioxetine
  • Yohimbine
  • Ziprasidone
  • Zolmitriptan
  • Zonisamide
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