Methazolamide

Methazolamide Brand Names- Glauctabs | Neptazane

What is Methazolamide

Methazolamide is an oral carbonic anhydrase inhibitor. It is used in the treatment of glaucoma to rapidly reduce intraocular pressure.

Methazolamide works by decreasing the production of aqueous humor. The drug is used off-label for the treatment of benign familial tremor and has also been used in prevention of altitude sickness.

A topical ophthalmic formulation of methazolamide complexed in cyclodextrin is being investigated for ocular hypertension.

Oral methazolamide (Neptazane®) was approved by the FDA in 1959.

Indications

  • altitude sickness
  • benign familial tremor
  • glaucoma
  • tremor

For the adjunctive treatment of open-angle glaucoma, for the treatment of secondary glaucoma, and for use pre-operatively for acute angle-closure glaucoma

Side Effects

  1. agranulocytosis
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. anorexia
  5. aplastic anemia
  6. asthenia
  7. confusion
  8. crystalluria
  9. diarrhea
  10. drowsiness
  11. dysgeusia
  12. dysuria
  13. erythema multiforme
  14. fatigue
  15. fever
  16. glycosuria
  17. hearing loss
  18. hematuria
  19. hemolysis
  20. hemolytic anemia
  21. hepatic encephalopathy
  22. hepatic necrosis
  23. hyperchloremia
  24. hyperglycemia
  25. hyperuricemia
  26. hypokalemia
  27. impotence (erectile dysfunction)
  28. increased urinary frequency
  29. leukopenia
  30. libido decrease
  31. malaise
  32. melena
  33. metabolic acidosis
  34. myalgia
  35. myopia
  36. nausea
  37. nephrolithiasis
  38. oliguria
  39. pancytopenia
  40. paresthesias
  41. photosensitivity
  42. pruritus
  43. rash
  44. renal tubular obstruction
  45. seizures
  46. Stevens-Johnson syndrome
  47. thrombocytopenia
  48. thrombotic thrombocytopenic purpura (TTP)
  49. tinnitus
  50. toxic epidermal necrolysis
  51. urticaria
  52. vertigo
  53. vomiting
  54. weakness
  55. weight loss
  56. xerostomia

Monitoring Parameters

  • CBC with differential
  • serum electrolytes

Contraindications

  • acid/base imbalance
  • acidemia
  • adrenal insufficiency
  • agranulocytosis
  • anuria
  • breast-feeding
  • bronchitis
  • carbonic anhydrase inhibitor hypersensitivity
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • diabetes mellitus
  • dialysis
  • driving or operating machinery
  • edema
  • electrolyte imbalance
  • emphysema
  • geriatric
  • hematological disease
  • hepatic disease
  • hyperchloremia
  • hypokalemia
  • hyponatremia
  • infants
  • metabolic acidosis
  • nephrolithiasis
  • pregnancy
  • pulmonary disease
  • renal disease
  • renal failure
  • renal impairment
  • sulfonamide hypersensitivity
  • sunlight (UV) exposure

Interactions

  • Acarbose
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Pseudoephedrine
  • Acetazolamide
  • Acetohexamide
  • Acrivastine; Pseudoephedrine
  • Albuterol
  • Albuterol; Ipratropium
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Ammonium Chloride
  • Amobarbital
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Arsenic Trioxide
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atenolol; Chlorthalidone
  • Atracurium
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azilsartan; Chlorthalidone
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Bepridil
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Butabarbital
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Phosphate, Supersaturated
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Central-acting adrenergic agents
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlorothiazide
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Choline Salicylate; Magnesium Salicylate
  • Ciprofloxacin
  • Cisapride
  • Cisatracurium
  • Citalopram
  • Clozapine
  • Corticosteroids
  • Cyclosporine
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextroamphetamine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Quinidine
  • Dichlorphenamide
  • Diflunisal
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Donepezil; Memantine
  • Doxacurium
  • Droperidol
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Ephedrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Ethotoin
  • Fexofenadine; Pseudoephedrine
  • Flecainide
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Gallium Ga 68 Dotatate
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Halofantrine
  • Haloperidol
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Pseudoephedrine
  • Iloprost
  • Inamrinone
  • Incretin Mimetics
  • Indapamide
  • Insulins
  • Isocarboxazid
  • Levalbuterol
  • Levomethadyl
  • Linagliptin
  • Linagliptin; Metformin
  • Lisdexamfetamine
  • Lithium
  • Loop diuretics
  • Loratadine; Pseudoephedrine
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Magnesium Salts
  • Mannitol
  • Mecamylamine
  • Mefloquine
  • Memantine
  • Mephobarbital
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methenamine
  • Methenamine; Sodium Acid Phosphate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyclothiazide
  • Metolazone
  • Mexiletine
  • Miglitol
  • Mivacurium
  • Monoamine oxidase inhibitors
  • Naproxen; Pseudoephedrine
  • Nateglinide
  • Nifedipine
  • Nitrates
  • Norfloxacin
  • Octreotide
  • Pancuronium
  • Pentobarbital
  • Phenelzine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenytoin
  • Pimozide
  • Potassium-sparing diuretics
  • Pramlintide
  • Primidone
  • Pseudoephedrine
  • Quetiapine
  • Quinidine
  • Quinine
  • Repaglinide
  • Reserpine
  • Rocuronium
  • Salicylates
  • Salsalate
  • Saxagliptin
  • Secobarbital
  • SGLT2 Inhibitors
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sotalol
  • Succinylcholine
  • Sulfonylureas
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Tolazamide
  • Tolbutamide
  • Tolterodine
  • Topiramate
  • Tranylcypromine
  • Tubocurarine
  • Urea
  • Vecuronium
  • Vorinostat
  • Zonisamide
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