Methazolamide Brand Names- Glauctabs | Neptazane
What is Methazolamide
Methazolamide is an oral carbonic anhydrase inhibitor. It is used in the treatment of glaucoma to rapidly reduce intraocular pressure.
Methazolamide works by decreasing the production of aqueous humor. The drug is used off-label for the treatment of benign familial tremor and has also been used in prevention of altitude sickness.
A topical ophthalmic formulation of methazolamide complexed in cyclodextrin is being investigated for ocular hypertension.
Oral methazolamide (Neptazane®) was approved by the FDA in 1959.
Indications
- altitude sickness
- benign familial tremor
- glaucoma
- tremor
For the adjunctive treatment of open-angle glaucoma, for the treatment of secondary glaucoma, and for use pre-operatively for acute angle-closure glaucoma
Side Effects
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anorexia
- aplastic anemia
- asthenia
- confusion
- crystalluria
- diarrhea
- drowsiness
- dysgeusia
- dysuria
- erythema multiforme
- fatigue
- fever
- glycosuria
- hearing loss
- hematuria
- hemolysis
- hemolytic anemia
- hepatic encephalopathy
- hepatic necrosis
- hyperchloremia
- hyperglycemia
- hyperuricemia
- hypokalemia
- impotence (erectile dysfunction)
- increased urinary frequency
- leukopenia
- libido decrease
- malaise
- melena
- metabolic acidosis
- myalgia
- myopia
- nausea
- nephrolithiasis
- oliguria
- pancytopenia
- paresthesias
- photosensitivity
- pruritus
- rash
- renal tubular obstruction
- seizures
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- toxic epidermal necrolysis
- urticaria
- vertigo
- vomiting
- weakness
- weight loss
- xerostomia
Monitoring Parameters
- CBC with differential
- serum electrolytes
Contraindications
- acid/base imbalance
- acidemia
- adrenal insufficiency
- agranulocytosis
- anuria
- breast-feeding
- bronchitis
- carbonic anhydrase inhibitor hypersensitivity
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- diabetes mellitus
- dialysis
- driving or operating machinery
- edema
- electrolyte imbalance
- emphysema
- geriatric
- hematological disease
- hepatic disease
- hyperchloremia
- hypokalemia
- hyponatremia
- infants
- metabolic acidosis
- nephrolithiasis
- pregnancy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- sulfonamide hypersensitivity
- sunlight (UV) exposure
Interactions
- Acarbose
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acetohexamide
- Acrivastine; Pseudoephedrine
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminosalicylate sodium, Aminosalicylic acid
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Ammonium Chloride
- Amobarbital
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Arsenic Trioxide
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atracurium
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Bepridil
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Butabarbital
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Central-acting adrenergic agents
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlorothiazide
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Ciprofloxacin
- Cisapride
- Cisatracurium
- Citalopram
- Clozapine
- Corticosteroids
- Cyclosporine
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextroamphetamine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Dichlorphenamide
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Donepezil; Memantine
- Doxacurium
- Droperidol
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Hydrochlorothiazide, HCTZ
- Ephedrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Ethotoin
- Fexofenadine; Pseudoephedrine
- Flecainide
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Gallium Ga 68 Dotatate
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Halofantrine
- Haloperidol
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Iloprost
- Inamrinone
- Incretin Mimetics
- Indapamide
- Insulins
- Isocarboxazid
- Levalbuterol
- Levomethadyl
- Linagliptin
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Loop diuretics
- Loratadine; Pseudoephedrine
- Magnesium Hydroxide
- Magnesium Salicylate
- Magnesium Salts
- Mannitol
- Mecamylamine
- Mefloquine
- Memantine
- Mephobarbital
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methenamine
- Methenamine; Sodium Acid Phosphate
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methyclothiazide
- Metolazone
- Mexiletine
- Miglitol
- Mivacurium
- Monoamine oxidase inhibitors
- Naproxen; Pseudoephedrine
- Nateglinide
- Nifedipine
- Nitrates
- Norfloxacin
- Octreotide
- Pancuronium
- Pentobarbital
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenytoin
- Pimozide
- Potassium-sparing diuretics
- Pramlintide
- Primidone
- Pseudoephedrine
- Quetiapine
- Quinidine
- Quinine
- Repaglinide
- Reserpine
- Rocuronium
- Salicylates
- Salsalate
- Saxagliptin
- Secobarbital
- SGLT2 Inhibitors
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sotalol
- Succinylcholine
- Sulfonylureas
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Tolazamide
- Tolbutamide
- Tolterodine
- Topiramate
- Tranylcypromine
- Tubocurarine
- Urea
- Vecuronium
- Vorinostat
- Zonisamide
