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Mercaptopurine 6 MP Brand Names- Purinethol | PURIXAN
What is Mercaptopurine 6 MP
Mercaptopurine is a purine antimetabolite. It is indicated for the treatment of acute lymphocytic/lymphoblastic leukemia as part of a combination regimen.
Mercaptopurine tablets are not indicated for the prophylaxis or treatment of central nervous system leukemia or for the treatment of acute myelogenous leukemia, chronic lymphocytic leukemia, lymphoma, or solid tumors.
Patients with thiopurine S-methyltransferase (TPMT) or nucleotide diphosphatase (NUDT15) deficiency may be at a higher risk for developing mercaptopurine toxicity, especially severe myelosuppression.
Indications
- acute lymphocytic leukemia (ALL)
- acute myelogenous leukemia (AML)
- chronic myelogenous leukemia (CML)
- Crohn’s disease
- ulcerative colitis
For the treatment of acute lymphocytic leukemia (ALL)
Side Effects
- alopecia
- anemia
- anorexia
- ascites
- bleeding
- cholestasis
- diarrhea
- elevated hepatic enzymes
- fever
- hepatic encephalopathy
- hepatic necrosis
- hepatitis
- hepatomegaly
- hyperbilirubinemia
- hyperuricemia
- hypoglycemia
- infection
- jaundice
- lymphoma
- lymphopenia
- malaise
- nausea
- neutropenia
- new primary malignancy
- oligospermia
- oral ulceration
- pancreatitis
- photosensitivity
- pulmonary fibrosis
- rash
- skin cancer
- skin hyperpigmentation
- spontaneous fetal abortion
- thrombocytopenia
- tumor lysis syndrome (TLS)
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum creatinine/BUN
- serum uric acid
Contraindications
- anemia
- autoimmune disease
- bone marrow suppression
- breast-feeding
- children
- contraception requirements
- hepatic disease
- hepatotoxicity
- hypoglycemia
- immunosuppression
- infants
- infection
- infertility
- inflammatory bowel disease
- intrauterine fetal death
- leukopenia
- male-mediated teratogenicity
- neutropenia
- new primary malignancy
- nucleotide diphosphatase deficiency
- pregnancy
- pregnancy testing
- renal impairment
- reproductive risk
- requires an experienced clinician
- sunlight (UV) exposure
- thiopurine methyltransferase deficiency
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vaccination
Interactions
- Allopurinol
- Alpha interferons
- Antithymocyte Globulin
- Azathioprine
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Balsalazide
- Basiliximab
- Beclomethasone
- Betamethasone
- Budesonide
- Budesonide; Formoterol
- Carbamazepine
- Ciclesonide
- Clozapine
- Corticosteroids
- Cortisone
- Cyclosporine
- Deflazacort
- Dexamethasone
- Doxorubicin
- Doxorubicin Liposomal
- Echinacea
- Efalizumab
- Febuxostat
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Hydrocortisone
- Infliximab
- Influenza Virus Vaccine
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Intranasal Influenza Vaccine
- Lesinurad; Allopurinol
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Mesalamine, 5-ASA
- Methotrexate
- Methylprednisolone
- Mometasone
- Muromonab-CD3
- Natalizumab
- Olsalazine
- Palifermin
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pexidartinib
- Platelet Inhibitors
- Porfimer
- Prednisolone
- Prednisone
- Riluzole
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Tbo-Filgrastim
- Tofacitinib
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Upadacitinib
- Varicella-Zoster Virus Vaccine, Live
- Verteporfin
- Warfarin
- Yellow Fever Vaccine, Live
