Mebendazole

Mebendazole Brand Names- Emverm | Vermox

What is Mebendazole

Mebendazole is an oral, broad-spectrum, synthetic anthelmintic agent that is structurally similar to thiabendazole.

Mebendazole is particularly effective against susceptible gastrointestinal nematodes, such as roundworms, whipworms, pinworms, and hookworms.

Along with pyrantel pamoate, mebendazole is considered the drug of choice in treating infections caused by these nematodes

Indications

  1. Ancylostoma duodenale
  2. Angiostrongylus costaricensis
  3. ascariasis
  4. Ascaris lumbricoides
  5. Capillaria philippinensis
  6. capillariasis
  7. Echinococcus granulosus
  8. enterobiasis (pinworm infection)
  9. Enterobius vermicularis
  10. Giardia lamblia
  11. Gnathostoma spinigerum
  12. hookworm infection
  13. hydatid cyst disease
  14. Hymenolepis nana
  15. Mansonella perstans
  16. Necator americanus
  17. Onchocerca volvulus
  18. Strongyloides stercoralis
  19. Taenia saginata
  20. Taenia solium
  21. toxocariasis
  22. Trichinella spiralis
  23. trichinosis
  24. trichuriasis
  25. Trichuris trichiura

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. alopecia
  4. anaphylactoid reactions
  5. angioedema
  6. anorexia
  7. diarrhea
  8. dizziness
  9. elevated hepatic enzymes
  10. flatulence
  11. glomerulonephritis
  12. hepatitis
  13. nausea
  14. neutropenia
  15. rash
  16. seizures
  17. Stevens-Johnson syndrome
  18. toxic epidermal necrolysis
  19. urticaria
  20. vomiting

Monitoring Parameters

  • CBC
  • LFTs

Contraindications

  • agranulocytosis
  • breast-feeding
  • hepatic disease
  • infants
  • neonates
  • neutropenia
  • pregnancy

Interactions

  • Barbiturates
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Carbamazepine
  • Cimetidine
  • Fosphenytoin
  • Metronidazole
  • Phenytoin
  • Rifamycins
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