Mecamylamine

Mecamylamine Brand Names- Inversine | Vecamyl

What is Mecamylamine

Mecamylamine is an oral, potent ganglion blocker originally marketed as an antihypertensive agent. It was approved by the FDA for the treatment of moderately severe to severe hypertension and uncomplicated malignant hypertension.

Mecamylamine is no longer used for hypertension because of the availability of safer and more effective antihypertensive agents.

If treatment with mecamylamine is required, carefully evaluate patients for medical conditions that can be exacerbated by drug-induced orthostatic hypotension or anticholinergic effects.

The FDA designated mecamylamine as an orphan drug for the treatment of Tourette’s syndrome in 1998; however, the drug is not recommended for this indication due to evidence of ineffectiveness during clinical trials.

Indications

  • hypertension

For the treatment of moderately-severe to severe essential hypertension or uncomplicated malignant hypertension

Side Effects

  1. anorexia
  2. blurred vision
  3. constipation
  4. dizziness
  5. drowsiness
  6. fatigue
  7. glossitis
  8. ileus
  9. impotence (erectile dysfunction)
  10. interstitial lung disease
  11. libido decrease
  12. mydriasis
  13. nausea
  14. orthostatic hypotension
  15. paresthesias
  16. pulmonary edema
  17. pulmonary fibrosis
  18. seizures
  19. syncope
  20. tremor
  21. urinary retention
  22. vomiting
  23. weakness
  24. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate
  • serum creatinine/BUN

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • arteriosclerosis
  • bladder obstruction
  • bleeding
  • breast-feeding
  • cardiac disease
  • cerebrovascular disease
  • children
  • coronary artery disease
  • ethanol ingestion
  • glaucoma
  • heart failure
  • hypertension
  • hyponatremia
  • hypovolemia
  • ileus
  • infants
  • infection
  • myocardial infarction
  • orthostatic hypotension
  • pregnancy
  • prostatic hypertrophy
  • pyloric stenosis
  • renal disease
  • renal failure
  • renal impairment
  • strenuous exercise
  • stroke
  • surgery
  • uremia
  • urethral stricture
  • urinary retention

Interactions

  • Acetazolamide
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alprostadil
  • Ambenonium Chloride
  • Amifostine
  • Amlodipine; Celecoxib
  • Amobarbital
  • Amyl Nitrite
  • Apomorphine
  • Apraclonidine
  • Aripiprazole
  • Asenapine
  • Baclofen
  • Bethanechol
  • Bortezomib
  • Bromocriptine
  • Cabergoline
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Celecoxib
  • Chloroprocaine
  • Clozapine
  • Co-Enzyme Q10, Ubiquinone
  • Cocaine
  • Colchicine; Probenecid
  • Conivaptan
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Enflurane
  • Epoprostenol
  • Esomeprazole; Naproxen
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etodolac
  • Etomidate
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Fospropofol
  • General anesthetics
  • Haloperidol
  • Halothane
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrocodone; Ibuprofen
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Indomethacin
  • Intravenous Lipid Emulsions
  • Isoflurane
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Ketamine
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Levodopa
  • Lovastatin; Niacin
  • Lurasidone
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Mestranol; Norethindrone
  • Methazolamide
  • Methohexital
  • Milrinone
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nefazodone
  • Neostigmine
  • Nesiritide, BNP
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Olanzapine
  • Oxaprozin
  • Paliperidone
  • Pentoxifylline
  • Piroxicam
  • Prazosin
  • Probenecid
  • Procainamide
  • Procaine
  • Propofol
  • Pyridostigmine
  • Quinidine
  • Rasagiline
  • Reserpine
  • Risperidone
  • Rofecoxib
  • Segesterone Acetate; Ethinyl Estradiol
  • Sevoflurane
  • Sibutramine
  • Silodosin
  • Sulfinpyrazone
  • Sulindac
  • Sympathomimetics
  • Tetrabenazine
  • Tetracaine
  • Thiopental
  • Thiothixene
  • Tizanidine
  • Tolmetin
  • Trazodone
  • Valdecoxib
  • Vasopressin, ADH
  • Yohimbine
  • Ziprasidone
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