Maprotiline Brand Name– Ludiomil
What is Maprotiline
Maprotiline is an oral tetracyclic antidepressant drug of dibenzo-bicyclo-octadiene derivation.
It is used for various types of depressive disorder such as unipolar depression, depressive neurosis, and the depressive phase of bipolar disorder. Most references consider maprotiline similar to traditional tricyclic antidepressants.
Maprotiline is also effective in treating anxiety associated with depression.
Maprotiline was approved for use by the FDA in 1980.
On October 15, 2004 the FDA directed manufacturers of all antidepressants to include a Black Box warning, expanded warning statements, and clinical trial results detailing the increased risk of suicidality in children and adolescents.
The warning was subsequently revised to include data on the increased risk of suicidality in young adults.
Indications
- depression
Side Effects
- abdominal pain
- agitation
- agranulocytosis
- akathisia
- alopecia
- anxiety
- ataxia
- AV block
- blurred vision
- breast enlargement
- confusion
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysgeusia
- dysphagia
- edema
- EEG changes
- elevated hepatic enzymes
- eosinophilia
- fatigue
- fever
- flushing
- galactorrhea
- gynecomastia
- hallucinations
- headache
- heart failure
- hyperglycemia
- hyperhidrosis
- hypersalivation
- hypertension
- hypoglycemia
- hypotension
- ileus
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- libido decrease
- libido increase
- mania
- memory impairment
- mydriasis
- myocardial infarction
- nasal congestion
- nausea
- nightmares
- ocular hypertension
- orthostatic hypotension
- palpitations
- paresthesias
- peripheral neuropathy
- petechiae
- photosensitivity
- pneumonitis
- PR prolongation
- pruritus
- psychosis
- purpura
- QT prolongation
- rash
- restlessness
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- stomatitis
- stroke
- suicidal ideation
- syncope
- testicular swelling
- thrombocytopenia
- tinnitus
- tongue discoloration
- torsade de pointes
- toxic epidermal necrolysis
- tremor
- urinary retention
- ventricular tachycardia
- vomiting
- weakness
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- blood pressure
- ECG
- heart rate
- LFTs
- thyroid function tests (TFTs)
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- agranulocytosis
- anticholinergic medications
- apheresis
- AV block
- bipolar disorder
- bradycardia
- breast-feeding
- bundle-branch block
- cardiac disease
- cardiomyopathy
- celiac disease
- children
- closed-angle glaucoma
- contact lenses
- driving or operating machinery
- electroconvulsive therapy (ECT)
- ethanol ingestion
- females
- fever
- geriatric
- heart failure
- hepatic disease
- human immunodeficiency virus (HIV) infection
- hyperparathyroidism
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypothermia
- hypothyroidism
- increased intraocular pressure
- long QT syndrome
- mania
- MAOI therapy
- myocardial infarction
- neonates
- neutropenia
- pheochromocytoma
- poor metabolizers
- pregnancy
- prostatic hypertrophy
- QT prolongation
- radiographic contrast administration
- rheumatoid arthritis
- seizure disorder
- seizures
- sickle cell disease
- sleep deprivation
- stroke
- suicidal ideation
- sunlight (UV) exposure
- surgery
- systemic lupus erythematosus (SLE)
- tricyclic antidepressant hypersensitivity
- urinary retention
Interactions
- Abarelix
- Abiraterone
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Alfuzosin
- Alosetron
- Alprazolam
- Amantadine
- Ambenonium Chloride
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Celecoxib
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amprenavir
- Anagrelide
- Anxiolytics; Sedatives; and Hypnotics
- Apomorphine
- Aprepitant, Fosaprepitant
- Arformoterol
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azithromycin
- Baclofen
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Bepridil
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Brexpiprazole
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Cannabidiol
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroquine
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cholinergic agonists
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clemastine
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Crizotinib
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Dacomitinib
- Dantrolene
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Dasatinib
- Degarelix
- Delavirdine
- Desflurane
- Desipramine
- Desloratadine; Pseudoephedrine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dicyclomine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Disulfiram
- Dobutamine
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dopamine
- Doxepin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Duloxetine
- Edrophonium
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entrectinib
- Ephedrine
- Epinephrine
- Eribulin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Estazolam
- Ethanol
- Ethosuximide
- Etomidate
- Everolimus
- Ezogabine
- Fedratinib
- Felbamate
- Fenfluramine
- Fentanyl
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Fingolimod
- Flavoxate
- Flecainide
- Fluconazole
- Flumazenil
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Gabapentin
- Galantamine
- Gemifloxacin
- Gemtuzumab Ozogamicin
- Gilteritinib
- Givosiran
- Glasdegib
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Goserelin
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Guanfacine
- Guselkumab
- Halofantrine
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxychloroquine
- Hydroxyzine
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Ibutilide
- Idelalisib
- Iloperidone
- Imatinib
- Imipramine
- Indacaterol
- Indacaterol; Glycopyrrolate
- Inotuzumab Ozogamicin
- Iobenguane I 131
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Itraconazole
- Ivosidenib
- Ketamine
- Ketoconazole
- Labetalol
- Lacosamide
- Lamotrigine
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Leuprolide; Norethindrone
- Levalbuterol
- Levetiracetam
- Levocetirizine
- Levodopa
- Levofloxacin
- Levomethadyl
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofexidine
- Lomefloxacin
- Long-acting beta-agonists
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorazepam
- Loxapine
- Lumateperone
- Macimorelin
- Magnesium Salts
- Meclizine
- Mefloquine
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine; Levonordefrin
- Mesoridazine
- Metaproterenol
- Metaxalone
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methscopolamine
- Methsuximide
- Methyldopa
- Methylene Blue
- Methylphenidate
- Metronidazole
- Metyrapone
- Midazolam
- Midodrine
- Midostaurin
- Mifepristone
- Minocycline
- Mirabegron
- Mirtazapine
- Mitotane
- Molindone
- Morphine
- Morphine; Naltrexone
- Moxifloxacin
- Nabilone
- Nalbuphine
- Naproxen; Pseudoephedrine
- Neostigmine
- Nilotinib
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Ondansetron
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Panobinostat
- Paroxetine
- Pasireotide
- Pazopanib
- Peginterferon Alfa-2b
- Pemoline
- Pentamidine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Pimavanserin
- Pimozide
- Pirbuterol
- Pitolisant
- Porfimer
- Posaconazole
- Pramipexole
- Pregabalin
- Prilocaine; Epinephrine
- Primaquine
- Primidone
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propantheline
- Propofol
- Propoxyphene
- Protriptyline
- Pseudoephedrine
- Pyridostigmine
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Racepinephrine
- Ranolazine
- Rasagiline
- Remifentanil
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rilpivirine
- Risperidone
- Ritodrine
- Ritonavir
- Rivastigmine
- Rolapitant
- Romidepsin
- Ropinirole
- Safinamide
- Salmeterol
- Saquinavir
- Scopolamine
- Secobarbital
- Selegiline
- Selpercatinib
- Sertraline
- Sevoflurane
- Short-acting beta-agonists
- Siponimod
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Sufentanil
- Sunitinib
- Sympathomimetics
- Tacrine
- Tacrolimus
- Tamoxifen
- Tapentadol
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Terbinafine
- Terbutaline
- Tetrabenazine
- Thiethylperazine
- Thiopental
- Thioridazine
- Thyroid hormones
- Tiagabine
- Tiotropium; Olodaterol
- Tolterodine
- Topiramate
- Toremifene
- Tramadol
- Tranylcypromine
- Trazodone
- Triazolam
- Triclabendazole
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimipramine
- Triprolidine
- Triptorelin
- Trospium
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Verteporfin
- Vigabatrin
- Voriconazole
- Vorinostat
- Ziconotide
- Ziprasidone
- Zonisamide