Lutropin alfa Brand Name– Luveris
What is Lutropin alfa
Lutropin alfa is recombinant human luteinizing hormone (r-hLH), synthesized using a Chinese hamster ovary cell line.
Lutropin alfa is indicated for the stimulation of follicular development in infertile hypogonadotropic hypogonadal women with profound LH deficiency (LH < 1.2 IU/L), a relatively rare condition.
Lutropin alfa should only be used when in combination with the Gonal-f® brand of follitropin, r-FSH as its safety and efficacy with other r-FSH products is not known.
Lutropin alfa was given an Orphan Drug designation from the FDA.
Lutropin alfa was approved by the FDA under the brand name Luveris® in October 2004.
Indications
- hypogonadism
- infertility
For the treatment of infertility in females due to hypogonadotropic hypogonadism exhibiting profound LH deficiency (LH less than 1.2 IU/L and FSH less than 5 IU/L)
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- anasarca
- arthralgia
- ascites
- chills
- constipation
- cough
- diarrhea
- dysmenorrhea
- dyspnea
- ectopic pregnancy
- elevated hepatic enzymes
- fever
- flatulence
- headache
- hypoalbuminemia
- hypotension
- hypovolemia
- injection site reaction
- malaise
- musculoskeletal pain
- nausea
- new primary malignancy
- oliguria
- ovarian enlargement
- ovarian hyperstimulation syndrome (OHSS)
- pelvic pain
- pericardial effusion
- phlebitis
- pleural effusion
- pulmonary edema
- pulmonary embolism
- sinus tachycardia
- spontaneous fetal abortion
- stroke
- tachypnea
- thromboembolism
- thrombosis
- vomiting
- weight gain
- xerosis
Monitoring Parameters
- pelvic exam
- pelvic ultrasound
- pregnancy testing
- serum estradiol concentrations
- serum gonadotropin concentrations
- weight
Contraindications
- adrenal insufficiency
- ascites
- asthma
- breast-feeding
- children
- dysfunctional uterine bleeding
- endometriosis
- geriatric
- neoplastic disease
- ovarian cyst
- ovarian failure
- pituitary adenoma
- polycystic ovary syndrome
- pregnancy
- thromboembolic disease
- thrombophlebitis
- thyroid disease
- tobacco smoking
- uterine leiomyomata
Interactions
There are no drug interactions associated with Lutropin alfa products.
