Lutropin alfa

Lutropin alfa Brand Name– Luveris

What is Lutropin alfa

Lutropin alfa is recombinant human luteinizing hormone (r-hLH), synthesized using a Chinese hamster ovary cell line.

Lutropin alfa is indicated for the stimulation of follicular development in infertile hypogonadotropic hypogonadal women with profound LH deficiency (LH < 1.2 IU/L), a relatively rare condition.

Lutropin alfa should only be used when in combination with the Gonal-f® brand of follitropin, r-FSH as its safety and efficacy with other r-FSH products is not known.

Lutropin alfa was given an Orphan Drug designation from the FDA.

Lutropin alfa was approved by the FDA under the brand name Luveris® in October 2004.

Indications

  • hypogonadism
  • infertility

For the treatment of infertility in females due to hypogonadotropic hypogonadism exhibiting profound LH deficiency (LH less than 1.2 IU/L and FSH less than 5 IU/L)

Side Effects

  1. abdominal pain
  2. acute respiratory distress syndrome (ARDS)
  3. anasarca
  4. arthralgia
  5. ascites
  6. chills
  7. constipation
  8. cough
  9. diarrhea
  10. dysmenorrhea
  11. dyspnea
  12. ectopic pregnancy
  13. elevated hepatic enzymes
  14. fever
  15. flatulence
  16. headache
  17. hypoalbuminemia
  18. hypotension
  19. hypovolemia
  20. injection site reaction
  21. malaise
  22. musculoskeletal pain
  23. nausea
  24. new primary malignancy
  25. oliguria
  26. ovarian enlargement
  27. ovarian hyperstimulation syndrome (OHSS)
  28. pelvic pain
  29. pericardial effusion
  30. phlebitis
  31. pleural effusion
  32. pulmonary edema
  33. pulmonary embolism
  34. sinus tachycardia
  35. spontaneous fetal abortion
  36. stroke
  37. tachypnea
  38. thromboembolism
  39. thrombosis
  40. vomiting
  41. weight gain
  42. xerosis

Monitoring Parameters

  • pelvic exam
  • pelvic ultrasound
  • pregnancy testing
  • serum estradiol concentrations
  • serum gonadotropin concentrations
  • weight

Contraindications

  • adrenal insufficiency
  • ascites
  • asthma
  • breast-feeding
  • children
  • dysfunctional uterine bleeding
  • endometriosis
  • geriatric
  • neoplastic disease
  • ovarian cyst
  • ovarian failure
  • pituitary adenoma
  • polycystic ovary syndrome
  • pregnancy
  • thromboembolic disease
  • thrombophlebitis
  • thyroid disease
  • tobacco smoking
  • uterine leiomyomata

Interactions

There are no drug interactions associated with Lutropin alfa products.

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